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    NEW ADJUVANT
    2.
    发明公开
    NEW ADJUVANT 审中-公开
    新的佐剂

    公开(公告)号：EP1893232A2

    公开(公告)日：2008-03-05

    申请号：EP06754608.5

    申请日：2006-06-20

    申请人： GLAXO GROUP LIMITED

    发明人： CATCHPOLE, Ian Richard ,  PAPANICOLAOU, Irene

    IPC分类号： A61K39/21 ,  A61P31/14

    CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55577 ,  C12N2710/10343 ,  C12N2740/16034

    摘要： The present invention provides a novel adjuvant for polynucleotide vaccines, and in particular the present invention provides immunogenic compositions comprising a polynucleotide encoding an antigen capable of eliciting an immune response and an adjuvant comprising an immunostimulatory quantity of a gemini surfactant, or a derivative thereof. The invention further comprises polynucleotide vaccines that comprise, or are administered in association with, a composition that comprises a gemini surfactant compound. The polynucleotide vaccines of the present invention are vaccines that encode an antigen against which it is desired to generate an immune response, and in particular the polynucleotide vaccine may be a DNA vaccine. Also provided by the present invention is the use of gemini surfactants in the manufacture of a polynucleotide vaccine composition for the purpose of enhancing the immune response against the specific antigen that is encoded by the polynucleotide vaccine. Vaccine compositions, kits comprising separate polynucleotide composition and adjuvant compositions for separate or simultaneous administration, methods of manufacture of the vaccines and kits, and methods of treatment of individuals with the immunogencic compositions and vaccines of the present invention, are provided.

    摘要翻译： 本发明提供了一种用于多核苷酸疫苗的新佐剂，具体地说，本发明提供了包含编码能够引发免疫应答的抗原的多核苷酸的免疫原性组合物和包含免疫刺激量的双子表面活性剂或其衍生物的佐剂。 本发明进一步包含多核苷酸疫苗，其包含包含双子表面活性剂化合物或与包含双子表面活性剂化合物的组合物联合施用。 本发明的多核苷酸疫苗是编码希望产生免疫应答的抗原的疫苗，特别是多核苷酸疫苗可以是DNA疫苗。 本发明还提供了双子表面活性剂在制备多核苷酸疫苗组合物中的用途，所述多核苷酸疫苗组合物用于增强针对由多核苷酸疫苗编码的特异性抗原的免疫应答。 提供了疫苗组合物，包含用于单独或同时施用的单独的多核苷酸组合物和佐剂组合物的试剂盒，制备疫苗和试剂盒的方法以及用本发明的免疫原性组合物和疫苗治疗个体的方法。

    ENCAPSULATION OF BIOLOGICALLY ACTIVE AGENTS
    4.
    发明公开
    ENCAPSULATION OF BIOLOGICALLY ACTIVE AGENTS 审中-公开
    生物活性剂的包封

    公开(公告)号：EP2273986A2

    公开(公告)日：2011-01-19

    申请号：EP09742073.1

    申请日：2009-05-05

    申请人： Glaxo Group Limited

    发明人： PAPANICOLAOU, Irene

    IPC分类号： A61K9/51

    CPC分类号： A61K9/5138 ,  A61K9/0019 ,  A61K9/0051 ,  A61K9/1647 ,  A61K9/5153 ,  A61K9/5192 ,  A61K2039/505

    摘要： The present invention provides methods of encapsulating biologically active agents such as proteins in particulate carriers such as nanoparticles using Hip agents. Also provided are compositions comprising particulate carriers obtainable by such methods and uses of such compositions in treatment.

    摘要翻译： 本发明提供了使用Hip试剂将生物活性剂例如蛋白质包封在颗粒载体例如纳米颗粒中的方法。 还提供了包含通过这样的方法可获得的颗粒载体的组合物和这种组合物在治疗中的用途。