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    ANTI-VEGF SINGLE VARIABLE DOMAINS FUSED TO FC DOMAINS
    3.
    发明公开
    ANTI-VEGF SINGLE VARIABLE DOMAINS FUSED TO FC DOMAINS 审中-公开
    MIT FC-DOMÄNENFUSIONIERBARE抗VEGF-EINZELVARIABLEN-DOMÄNEN

    公开(公告)号：EP2736925A2

    公开(公告)日：2014-06-04

    申请号：EP12738476.6

    申请日：2012-07-25

    申请人： Glaxo Group Limited

    发明人： ASHMAN, Claire ,  CATCHPOLE, Ian Richard ,  HUGHES-THOMAS, Zoe ,  LEWIS, Alan Peter ,  STEWARD, Michael

    IPC分类号： C07K16/22

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/70 ,  C07K16/46 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/60 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

    摘要： The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs.

    摘要翻译： 本发明涉及包含由抗体的单链Fc区分离的一个或两个表位结合结构域的抗原结合构建体，其中能够结合VEGF的每个表位结合域与包含本发明的两个抗原结合构建体的二聚体， 包含所述二聚体的药物组合物及其用于治疗与VEGF信号传导相关的疾病，例如糖尿病性黄斑水肿（DME），湿性年龄相关性黄斑变性（湿性AMD），糖尿病性视网膜病变，视网膜静脉阻塞（RVO）和角膜 新血管形成和编码所述抗原结合构建体的多核苷酸序列。

    NEW ADJUVANT
    5.
    发明公开
    NEW ADJUVANT 审中-公开
    新的佐剂

    公开(公告)号：EP1893232A2

    公开(公告)日：2008-03-05

    申请号：EP06754608.5

    申请日：2006-06-20

    申请人： GLAXO GROUP LIMITED

    发明人： CATCHPOLE, Ian Richard ,  PAPANICOLAOU, Irene

    IPC分类号： A61K39/21 ,  A61P31/14

    CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55577 ,  C12N2710/10343 ,  C12N2740/16034

    摘要： The present invention provides a novel adjuvant for polynucleotide vaccines, and in particular the present invention provides immunogenic compositions comprising a polynucleotide encoding an antigen capable of eliciting an immune response and an adjuvant comprising an immunostimulatory quantity of a gemini surfactant, or a derivative thereof. The invention further comprises polynucleotide vaccines that comprise, or are administered in association with, a composition that comprises a gemini surfactant compound. The polynucleotide vaccines of the present invention are vaccines that encode an antigen against which it is desired to generate an immune response, and in particular the polynucleotide vaccine may be a DNA vaccine. Also provided by the present invention is the use of gemini surfactants in the manufacture of a polynucleotide vaccine composition for the purpose of enhancing the immune response against the specific antigen that is encoded by the polynucleotide vaccine. Vaccine compositions, kits comprising separate polynucleotide composition and adjuvant compositions for separate or simultaneous administration, methods of manufacture of the vaccines and kits, and methods of treatment of individuals with the immunogencic compositions and vaccines of the present invention, are provided.

    摘要翻译： 本发明提供了一种用于多核苷酸疫苗的新佐剂，具体地说，本发明提供了包含编码能够引发免疫应答的抗原的多核苷酸的免疫原性组合物和包含免疫刺激量的双子表面活性剂或其衍生物的佐剂。 本发明进一步包含多核苷酸疫苗，其包含包含双子表面活性剂化合物或与包含双子表面活性剂化合物的组合物联合施用。 本发明的多核苷酸疫苗是编码希望产生免疫应答的抗原的疫苗，特别是多核苷酸疫苗可以是DNA疫苗。 本发明还提供了双子表面活性剂在制备多核苷酸疫苗组合物中的用途，所述多核苷酸疫苗组合物用于增强针对由多核苷酸疫苗编码的特异性抗原的免疫应答。 提供了疫苗组合物，包含用于单独或同时施用的单独的多核苷酸组合物和佐剂组合物的试剂盒，制备疫苗和试剂盒的方法以及用本发明的免疫原性组合物和疫苗治疗个体的方法。

    FLUORESCENTLY LABELLED LOCKED NUCLEIC ACIDS
    6.
    发明公开
    FLUORESCENTLY LABELLED LOCKED NUCLEIC ACIDS 审中-公开
    荧光标记的锁定核酸

    公开(公告)号：EP1409701A2

    公开(公告)日：2004-04-21

    申请号：EP02735619.5

    申请日：2002-06-14

    申请人： GLAXO GROUP LIMITED

    发明人： CATCHPOLE, Ian Richard

    IPC分类号： C12N15/87 ,  A61K49/00 ,  A61K47/48

    CPC分类号： A61K49/0054 ,  A61K47/54 ,  A61K47/549 ,  A61K49/0041 ,  A61K49/0056

    摘要： The present invention relates to compositions comprising DNA attached to one or more functional moities via a locked nucleic acid oligonucleotide. In particular the present invention provides compositions comprising a plasmid containing a gene encoding a protein of interest, wherein said plasmid may be introduced to a tissue or cell and the gene expressed, complexed to the LNA-functional moiety.

    摘要翻译： 本发明涉及包含通过锁核酸寡核苷酸连接到一个或多个功能部分的DNA的组合物。 具体而言，本发明提供了包含含有编码感兴趣蛋白质的基因的质粒的组合物，其中所述质粒可以被引入组织或细胞并且所述基因被表达，与LNA-功能部分复合。