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公开(公告)号：EP2382986A3
公开(公告)日：2012-08-22
申请号：EP10194592.1
申请日：2006-12-20
发明人： Biemans, Ralph Leon , Garcon, Nathalie Marie-Josephe , Hermand, Philippe Vincent , Poolman, Jan , Van Mechelen, Marcelle Paulette
CPC分类号： A61K39/385 , A61K39/092 , A61K47/6415 , A61K47/646 , A61K2039/545 , A61K2039/55 , A61K2039/555 , A61K2039/55566 , A61K2039/575 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/62 , A61K2039/627 , A61K2039/70 , Y02A50/412
摘要： The present invention discloses an immunogenic composition comprising S. pneumoniae capsular saccharide conjugates from serotypes 19A and 19F wherein 19A is conjugated to a first bacterial toxoid and 19F is conjugated to a second bacterial toxoid. Vaccines, methods of making vaccines and uses of the vaccines are also described.
摘要翻译： 本发明涉及肺炎球菌荚膜糖共轭疫苗领域。 具体地，提供了多价的肺炎链球菌免疫原性组合物，其包含与载体蛋白缀合的不同肺炎链球菌血清型的10种或更多种荚膜糖，并且包含3种或更多种不同的载体蛋白，其中所述组合物包含：血清型19F荚膜糖缀合至 白喉类毒素（DT）; 与破伤风类毒素（TT）结合的血清型18C荚膜糖; 血清型1,4,5,6B，7F，9V，14和23F荚膜糖结合到来自流感嗜血杆菌的蛋白D。
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公开(公告)号：EP2201961B1
公开(公告)日：2018-01-24
申请号：EP10158046.2
申请日：2006-06-23
发明人： Biemans, Ralph Leon , Poolman, Jan , Duvivier, Pierre , Denoel, Philippe , Capiau, Carine , Boutriau, Dominique
IPC分类号： A61K39/095 , A61K39/102 , A61K39/116
CPC分类号： A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/484
摘要： The present application discloses an immunogenic composition comprising a Hib saccharide conjugate and at least two further bacterial saccharide conjugates wherein the Hib conjugate is present in a lower saccharide dose than the mean saccharide dose of all the at least two further bacterial saccharide conjugates.
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公开(公告)号：EP2382986A2
公开(公告)日：2011-11-02
申请号：EP10194592.1
申请日：2006-12-20
发明人： Biemans, Ralph Leon , Garcon, Nathalie Marie-Josephe , Hermand, Philippe Vincent , Poolman, Jan , Van Mechelen, Marcelle Paulette
IPC分类号： A61K39/09
CPC分类号： A61K39/385 , A61K39/092 , A61K47/6415 , A61K47/646 , A61K2039/545 , A61K2039/55 , A61K2039/555 , A61K2039/55566 , A61K2039/575 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/62 , A61K2039/627 , A61K2039/70 , Y02A50/412
摘要： The present invention discloses an immunogenic composition comprising S. pneumoniae capsular saccharide conjugates from serotypes 19A and 19F wherein 19A is conjugated to a first bacterial toxoid and 19F is conjugated to a second bacterial toxoid. Vaccines, methods of making vaccines and uses of the vaccines are also described.
摘要翻译： 本发明公开了一种免疫原性组合物，其包含血清型19A和19F的肺炎链球菌荚膜糖共轭物，其中19A与第一种细菌类毒素结合，19F与第二种细菌类毒素结合。 还描述疫苗，疫苗的制备方法和疫苗的用途。
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4.发明公开Conjugation process of bacterial polysaccharides to carrier proteins 有权Konjugationsverfahrenfürbakterielle多糖一种Trägerproteine
公开(公告)号：EP2815762A2
公开(公告)日：2014-12-24
申请号：EP14181075.4
申请日：2011-03-07
IPC分类号： A61K39/02
CPC分类号： A61K47/48261 , A61K39/092 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/62
摘要： Process for conjugation of bacterial saccharides including Streptococcus pneumoniae and Haemophilus influenzae saccharides by reductive amination are provided herein.
摘要翻译： 本文提供了通过还原胺化法共轭细菌糖包括肺炎链球菌和流感嗜血杆菌糖的方法。
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公开(公告)号：EP2687228A3
公开(公告)日：2014-04-30
申请号：EP13189338.0
申请日：2008-06-24
CPC分类号： A61K39/092 , A61K39/09 , A61K39/116 , A61K47/646 , A61K2039/55 , A61K2039/55555 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/70
摘要： The present invention discloses an immunogenic composition comprising S. pneumoniae capsular saccharide conjugates from serotypes 19A and 19F wherein 19A is conjugated to a first bacterial toxoid and 19F is conjugated to a second bacterial toxoid. Vaccines, methods of making vaccines and uses of the vaccines are also described.
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公开(公告)号：EP2384765A2
公开(公告)日：2011-11-09
申请号：EP10192663.2
申请日：2006-12-20
发明人： Biemans, Ralph Leon , Garcon, Nathalie Marie-Josephe , Hermand, Philippe Vincent , Poolman, Jan , Van Mechelen, Marcelle Paulette
IPC分类号： A61K39/09
CPC分类号： A61K39/385 , A61K39/092 , A61K47/6415 , A61K47/646 , A61K2039/545 , A61K2039/55 , A61K2039/555 , A61K2039/55566 , A61K2039/575 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/62 , A61K2039/627 , A61K2039/70 , Y02A50/412
摘要： The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, a multivalent Streptococcus pneumoniae immunogenic composition is provided comprising 10 or more capsular saccharides from different S. pneumoniae serotypes which are conjugated to a carrier protein, and comprising 3 or more different carrier proteins, wherein the composition comprises:
serotype 19F capsular saccharide conjugated to diphtheria toxoid (DT);
serotype 18C capsular saccharide conjugated to tetanus toxoid (TT);
serotype 1,4,5,6B,7F,9V,14 and 23F capsular saccharides conjugated to protein D from Haemophilus influenzae .-
7.发明授权
公开(公告)号：EP2687228B1
公开(公告)日：2017-07-19
申请号：EP13189338.0
申请日：2008-06-24
CPC分类号： A61K39/092 , A61K39/09 , A61K39/116 , A61K47/646 , A61K2039/55 , A61K2039/55555 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/70
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公开(公告)号：EP2384765B1
公开(公告)日：2016-11-23
申请号：EP10192663.2
申请日：2006-12-20
发明人： Biemans, Ralph Leon , Garcon, Nathalie Marie-Josephe , Hermand, Philippe Vincent , Poolman, Jan , Van Mechelen, Marcelle Paulette
IPC分类号： A61K39/09
CPC分类号： A61K39/385 , A61K39/092 , A61K47/6415 , A61K47/646 , A61K2039/545 , A61K2039/55 , A61K2039/555 , A61K2039/55566 , A61K2039/575 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/62 , A61K2039/627 , A61K2039/70 , Y02A50/412
摘要： The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, a multivalent Streptococcus pneumoniae immunogenic composition is provided comprising 10 or more capsular saccharides from different S. pneumoniae serotypes which are conjugated to a carrier protein, and comprising 3 or more different carrier proteins, wherein the composition comprises: serotype 19F capsular saccharide conjugated to diphtheria toxoid (DT); serotype 18C capsular saccharide conjugated to tetanus toxoid (TT); serotype 1,4,5,6B,7F,9V,14 and 23F capsular saccharides conjugated to protein D from Haemophilus influenzae .
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公开(公告)号：EP2815762A3
公开(公告)日：2015-03-25
申请号：EP14181075.4
申请日：2011-03-07
IPC分类号： A61K39/02
CPC分类号： A61K47/48261 , A61K39/092 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/62
摘要： Process for conjugation of bacterial saccharides including Streptococcus pneumoniae and Haemophilus influenzae saccharides by reductive amination are provided herein.
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10.发明公开
公开(公告)号：EP2687228A2
公开(公告)日：2014-01-22
申请号：EP13189338.0
申请日：2008-06-24
CPC分类号： A61K39/092 , A61K39/09 , A61K39/116 , A61K47/646 , A61K2039/55 , A61K2039/55555 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/70
摘要： The present invention discloses an immunogenic composition comprising S. pneumoniae capsular saccharide conjugates from serotypes 19A and 19F wherein 19A is conjugated to a first bacterial toxoid and 19F is conjugated to a second bacterial toxoid. Vaccines, methods of making vaccines and uses of the vaccines are also described.
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