专利检索 ap:("GlaxoSmithKline Biologicals SA" OR "INFECTIOUS DISEASE RESEARCH INSTITUTE (IDRI)") AND inv:"LOBET, Yves, GlaxoSmithKline Biologicals s.a." 第 1 页

1.

发明公开
NOVEL METHOD FOR PREVENTING OR TREATING M TUBERCULOSIS INFECTION 有权
标题翻译：方法预防和治疗结核分枝杆菌感染

公开(公告)号：EP1877426A2

公开(公告)日：2008-01-16

申请号：EP06753523.7

申请日：2006-04-27

申请人： GlaxoSmithKline Biologicals SA , INFECTIOUS DISEASE RESEARCH INSTITUTE (IDRI)

发明人： COLER, Rhea, Infectious Disease Research Institute , LOBET, Yves, GlaxoSmithKline Biologicals s.a. , REED, Steven, Infectious Disease Research Inst.

IPC分类号： C07K14/35 , A61K39/04

CPC分类号： A61K39/04 , A61K31/4409 , A61K31/496 , A61K2039/523 , A61K2039/53 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , C07K14/35

摘要： The present invention is directed to methods of preventing reactivation of active and latent M. tuberculosis infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a M. tuberculosis infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a M. tuberculosis infection.