公开(公告)号：EP2333549A3

公开(公告)日：2011-11-02

申请号：EP10179009.5

申请日：2005-09-05

申请人： GlaxoSmithKline Biologicals s.a.

发明人： De Vleeschauwer, Isabel ,  Durant, Nathalie ,  Poolman, Jan ,  Weynants, Vincent

IPC分类号： G01N33/569 ,  C12N1/22

CPC分类号： G01N33/56911 ,  G01N2333/22 ,  G01N2469/20

摘要： The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular N. meningitidis. The SBA assay is the most important method for measuring functional activity of serum antibodies against meningococcus. In order to determine whether a subject or a population is seropositive against invasive meningococcus the SBA test should ideally be both sensitive and specific. The inventors have found the standard N. meningitidis serotype A and W SBAs can be significantly improved in this regard.

公开(公告)号：EP2336777B1

公开(公告)日：2013-04-03

申请号：EP10179015.2

申请日：2005-09-05

申请人： GlaxoSmithKline Biologicals s.a.

发明人： De Vleeschauwer, Isabel ,  Durant, Nathalie ,  Poolman, Jan ,  Weynants, Vincent

IPC分类号： G01N33/569 ,  C12N1/22

CPC分类号： G01N33/56911 ,  G01N2333/22 ,  G01N2469/20

公开(公告)号：EP2333549A2

公开(公告)日：2011-06-15

申请号：EP10179009.5

申请日：2005-09-05

申请人： GlaxoSmithKline Biologicals s.a.

发明人： De Vleeschauwer, Isabel ,  Durant, Nathalie ,  Poolman, Jan ,  Weynants, Vincent

IPC分类号： G01N33/569 ,  C12N1/22

CPC分类号： G01N33/56911 ,  G01N2333/22 ,  G01N2469/20

摘要： The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular N. meningitidis. The SBA assay is the most important method for measuring functional activity of serum antibodies against meningococcus. In order to determine whether a subject or a population is seropositive against invasive meningococcus the SBA test should ideally be both sensitive and specific. The inventors have found the standard N. meningitidis serotype A and W SBAs can be significantly improved in this regard.

摘要翻译： 本发明涉及革兰氏阴性细菌特别是脑膜炎奈瑟氏球菌的血清杀菌活性（SBA）测定领域。 SBA测定是测量针对脑膜炎球菌的血清抗体的功能活性的最重要的方法。 为了确定受试者或人群是否对侵袭性脑膜炎球菌具有血清反应性，SBA测试应理想地既敏感又特异。 发明人已经发现标准脑膜炎奈瑟球菌血清型A和W SBA在这方面可以显着改善。

公开(公告)号：EP2336777A1

公开(公告)日：2011-06-22

申请号：EP10179015.2

申请日：2005-09-05

申请人： GlaxoSmithKline Biologicals s.a.

发明人： De Vleeschauwer, Isabel ,  Durant, Nathalie ,  Poolman, Jan ,  Weynants, Vincent

IPC分类号： G01N33/569 ,  C12N1/22

CPC分类号： G01N33/56911 ,  G01N2333/22 ,  G01N2469/20

摘要： The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular N. meningitidis. The SBA assay is the most important method for measuring functional activity of serum antibodies against meningococcus. In order to determine whether a subject or a population is seropositive against invasive meningococcus the SBA test should ideally be both sensitive and specific. The inventors have found the standard N. meningitidis serotype A and W SBAs can be significantly improved in this regard.

摘要翻译： 本发明涉及革兰氏阴性细菌，特别是脑膜炎奈瑟氏球菌的血清杀菌活性（SBA）测定领域。 SBA测定法是测定脑膜炎球菌血清抗体功能活性的最重要方法。 为了确定受试者或群体是否对侵袭性脑膜炎球菌血清阳性，SBA检测应理想地既敏感又特异。 本发明人发现，在这方面可以显着改善脑膜炎奈瑟氏球菌血清型A和W SBA。