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公开(公告)号：EP1774977A3
公开(公告)日：2007-07-04
申请号：EP06124088.3
申请日：2000-07-31
发明人： Berthet, Francois-Xavier Jacques , Dalemans, Wilfred L. J. , Denoel, Philippe , Dequesne, Guy , Feron, Christiane , Lobet, Yves , Poolman, Jan , Thiry, Georges , Thonnard, Joelle , Voet, Pierre
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/145 , A61K47/6911 , A61K2039/522 , A61K2039/55505 , A61K2039/55544 , A61K2039/70 , C07K14/22 , C12N15/102 , C12N15/74
摘要： The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are characterized by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
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公开(公告)号：EP1787655A2
公开(公告)日：2007-05-23
申请号：EP06124085.9
申请日：2000-07-31
发明人： Berthet, Francois-Xavier J. , Dalemans, Wilfried L. J. , Denoel, Philippe , Dequesne, Guy , Feron, Christiane , Lobet, Yves , Poolman, Jan , Thiry, Georges , Thonnard, Joelle , Voet, Pierre
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/145 , A61K47/6911 , A61K2039/522 , A61K2039/55505 , A61K2039/55544 , A61K2039/70 , C07K14/22 , C12N15/102 , C12N15/74
摘要： The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
摘要翻译： 本发明涉及适用于儿科用途的免疫保护性和无毒革兰氏阴性泡状疫苗。 制造泡状体的革兰氏阴性菌株的实例是脑膜炎奈瑟菌，卡他莫拉菌和流感嗜血杆菌。 本发明的泡沫在细菌的染色体中具有一个或多个遗传变化，包括保护性抗原的上调，免疫显性非保护性抗原的下调和LPS的脂质A部分的解毒。
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公开(公告)号：EP1787655A3
公开(公告)日：2008-02-13
申请号：EP06124085.9
申请日：2000-07-31
发明人： Berthet, Francois-Xavier J. , Dalemans, Wilfried L. J. , Denoel, Philippe , Dequesne, Guy , Feron, Christiane , Lobet, Yves , Poolman, Jan , Thiry, Georges , Thonnard, Joelle , Voet, Pierre
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/145 , A61K47/6911 , A61K2039/522 , A61K2039/55505 , A61K2039/55544 , A61K2039/70 , C07K14/22 , C12N15/102 , C12N15/74
摘要： The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention have one or more genetic changes in the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
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公开(公告)号：EP1774977A2
公开(公告)日：2007-04-18
申请号：EP06124088.3
申请日：2000-07-31
发明人： Berthet, Francois-Xavier Jacques , Dalemans, Wilfred L. J. , Denoel, Philippe , Dequesne, Guy , Feron, Christiane , Lobet, Yves , Poolman, Jan , Thiry, Georges , Thonnard, Joelle , Voet, Pierre
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/145 , A61K47/6911 , A61K2039/522 , A61K2039/55505 , A61K2039/55544 , A61K2039/70 , C07K14/22 , C12N15/102 , C12N15/74
摘要： The present invention relates to an immune-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
摘要翻译： 本发明涉及适用于儿科用途的免疫保护性和无毒革兰氏阴性泡状疫苗。 制造泡状体的革兰氏阴性菌株的实例是脑膜炎奈瑟菌，卡他莫拉菌和流感嗜血杆菌。 本发明的泡沫的特征在于对细菌染色体的一个或多个遗传变化，包括保护性抗原的上调，免疫显性非保护性抗原的下调和LPS的脂质A部分的解毒。
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