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1.发明公开Novel method for preventing or treating m tuberculosis infection 有权Neues Verfahren zur Vorbeugung oder Behandlung einer Infektion mit M. tuberculosis
公开(公告)号：EP2457926A1
公开(公告)日：2012-05-30
申请号：EP11190080.9
申请日：2006-04-27
发明人： Coler, Rhea , Lobet, Yves , Reed, Steven
CPC分类号： A61K39/04 , A61K31/4409 , A61K31/496 , A61K2039/523 , A61K2039/53 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , C07K14/35
摘要： The present invention is directed to methods of preventing reactivation of active and latent M. tuberculosis infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a M. tuberculosis infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a M. tuberculosis infection.
摘要翻译： 本发明涉及通过施用包含编码Mtb72f融合蛋白或Mtb72f融合蛋白或其免疫原性片段的核酸的药物组合物，例如与佐剂一起施用来防止活性和潜伏性结核分枝杆菌感染的再活化的方法 。 Mtb72f核酸或融合蛋白可以与一种或多种针对结核分枝杆菌感染有效的化学治疗剂一起施用。 所述方法还提供了缩短针对结核分枝杆菌感染的化疗方案的时间过程。
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公开(公告)号：EP2392348A2
公开(公告)日：2011-12-07
申请号：EP11163894.6
申请日：2006-03-24
发明人： Alderson, Mark , Barth, Brenda , Bhatia, Ajay , Lobet, Yves , Maisonneuve, Jean-Francois L. , Marchand, Martine , Mettens, Pascal , Nozay, Florence, Bernadette , Probst, Peter , Skeiky, Yasir A.
IPC分类号： A61K39/118 , C07K14/295
CPC分类号： A61K39/118 , A61K2039/55572 , A61K2039/55577 , C07K14/295
摘要： The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
摘要翻译： 本发明涉及包含衣原体的蛋白质或多核苷酸的组合物，特别是编码它们的蛋白质或多核苷酸的组合，以及在治疗，预防和诊断衣原体感染中使用蛋白质或多核苷酸的方法。
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公开(公告)号：EP1787655A2
公开(公告)日：2007-05-23
申请号：EP06124085.9
申请日：2000-07-31
发明人： Berthet, Francois-Xavier J. , Dalemans, Wilfried L. J. , Denoel, Philippe , Dequesne, Guy , Feron, Christiane , Lobet, Yves , Poolman, Jan , Thiry, Georges , Thonnard, Joelle , Voet, Pierre
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/145 , A61K47/6911 , A61K2039/522 , A61K2039/55505 , A61K2039/55544 , A61K2039/70 , C07K14/22 , C12N15/102 , C12N15/74
摘要： The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
摘要翻译： 本发明涉及适用于儿科用途的免疫保护性和无毒革兰氏阴性泡状疫苗。 制造泡状体的革兰氏阴性菌株的实例是脑膜炎奈瑟菌，卡他莫拉菌和流感嗜血杆菌。 本发明的泡沫在细菌的染色体中具有一个或多个遗传变化，包括保护性抗原的上调，免疫显性非保护性抗原的下调和LPS的脂质A部分的解毒。
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公开(公告)号：EP2392349A2
公开(公告)日：2011-12-07
申请号：EP11163896.1
申请日：2006-03-24
发明人： Alderson, Mark , Barth, Brenda , Bhatia, Ajay , Lobet, Yves , Maisonneuve, Jean-Francois L. , Marchand, Martine , Mettens, Pascal , Nozay, Florence, Bernadette , Probst, Peter , Skeiky, Yasir A.
IPC分类号： A61K39/118 , C07K14/295
CPC分类号： A61K39/118 , A61K2039/55572 , A61K2039/55577 , C07K14/295
摘要： The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
摘要翻译： 本发明涉及包含衣原体属（Chlamydia sp。）的蛋白质或多核苷酸的组合物，特别是编码它们的蛋白质或多核苷酸的组合，以及在治疗，预防和诊断衣原体感染中使用蛋白质或多核苷酸的方法。
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公开(公告)号：EP2140878A1
公开(公告)日：2010-01-06
申请号：EP09173889.8
申请日：2001-09-12
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/095 , A61K39/102 , A61K39/13 , A61K39/292 , A61K2039/55 , A61K2039/55572 , A61K2039/6068 , Y02A50/396 , Y02A50/466
摘要： The present invention relates to a combination of 2 or more S pneumoniae proteins, their manufacture and use in medicine as a vaccine. Such combinations are particularly useful for the protection of infants and elderly against streptococcal infection.
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公开(公告)号：EP1787655A3
公开(公告)日：2008-02-13
申请号：EP06124085.9
申请日：2000-07-31
发明人： Berthet, Francois-Xavier J. , Dalemans, Wilfried L. J. , Denoel, Philippe , Dequesne, Guy , Feron, Christiane , Lobet, Yves , Poolman, Jan , Thiry, Georges , Thonnard, Joelle , Voet, Pierre
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/145 , A61K47/6911 , A61K2039/522 , A61K2039/55505 , A61K2039/55544 , A61K2039/70 , C07K14/22 , C12N15/102 , C12N15/74
摘要： The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention have one or more genetic changes in the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
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公开(公告)号：EP1774977A2
公开(公告)日：2007-04-18
申请号：EP06124088.3
申请日：2000-07-31
发明人： Berthet, Francois-Xavier Jacques , Dalemans, Wilfred L. J. , Denoel, Philippe , Dequesne, Guy , Feron, Christiane , Lobet, Yves , Poolman, Jan , Thiry, Georges , Thonnard, Joelle , Voet, Pierre
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/145 , A61K47/6911 , A61K2039/522 , A61K2039/55505 , A61K2039/55544 , A61K2039/70 , C07K14/22 , C12N15/102 , C12N15/74
摘要： The present invention relates to an immune-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
摘要翻译： 本发明涉及适用于儿科用途的免疫保护性和无毒革兰氏阴性泡状疫苗。 制造泡状体的革兰氏阴性菌株的实例是脑膜炎奈瑟菌，卡他莫拉菌和流感嗜血杆菌。 本发明的泡沫的特征在于对细菌染色体的一个或多个遗传变化，包括保护性抗原的上调，免疫显性非保护性抗原的下调和LPS的脂质A部分的解毒。
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公开(公告)号：EP2140878B1
公开(公告)日：2015-08-26
申请号：EP09173889.8
申请日：2001-09-12
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/095 , A61K39/102 , A61K39/13 , A61K39/292 , A61K2039/55 , A61K2039/55572 , A61K2039/6068 , Y02A50/396 , Y02A50/466
摘要： The present invention relates to a combination of 2 or more S pneumoniae proteins, their manufacture and use in medicine as a vaccine. Such combinations are particularly useful for the protection of infants and elderly against streptococcal infection.
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公开(公告)号：EP2392349A3
公开(公告)日：2012-01-18
申请号：EP11163896.1
申请日：2006-03-24
发明人： Alderson, Mark , Barth, Brenda , Bhatia, Ajay , Lobet, Yves , Maisonneuve, Jean-Francois L. , Marchand, Martine , Mettens, Pascal , Nozay, Florence, Bernadette , Probst, Peter , Skeiky, Yasir A.
IPC分类号： A61K39/118 , C07K14/295
CPC分类号： A61K39/118 , A61K2039/55572 , A61K2039/55577 , C07K14/295
摘要： The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
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公开(公告)号：EP2392348A3
公开(公告)日：2012-01-18
申请号：EP11163894.6
申请日：2006-03-24
发明人： Alderson, Mark , Barth, Brenda , Bhatia, Ajay , Lobet, Yves , Maisonneuve, Jean-Francois L. , Marchand, Martine , Mettens, Pascal , Nozay, Florence, Bernadette , Probst, Peter , Skeiky, Yasir A.
IPC分类号： A61K39/118 , C07K14/295
CPC分类号： A61K39/118 , A61K2039/55572 , A61K2039/55577 , C07K14/295
摘要： The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
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