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公开(公告)号：EP3375780B1
公开(公告)日：2020-06-03
申请号：EP18152185.7
申请日：2014-02-14
发明人： BANDYOPADHYAY, Deepak , EIDAM, Patrick M. , GOUGH, Peter J. , HARRIS, Philip Anthony , JEONG, Jae U. , KANG, Jianxing , KING, Bryan Wayne , LAKDAWALA SHAH, Ami , MARQUIS, JR., Robert W. , LEISTER, Lara Kathryn , RAHMAN, Attiq , RAMANJULU, Joshi M. , SEHON, Clark A. , SINGHAUS, JR., Robert , ZHANG, Daohua
IPC分类号： C07D403/12 , C07D413/14 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D267/14 , C07D498/04 , C07D281/10 , A61P37/00 , A61P25/28 , A61P17/06 , A61P29/00 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , C07D223/08
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公开(公告)号：EP2956452A1
公开(公告)日：2015-12-23
申请号：EP14705891.1
申请日：2014-02-14
发明人： BANDYOPADHYAY, Deepak , EIDAM, Patrick M. , GOUGH, Peter J. , HARRIS, Philip Anthony , JEONG, Jae U. , KANG, Jianxing , KING, Bryan Wayne , LAKDAWALA SHAH, Ami , MARQUIS, JR., Robert W. , LEISTER, Lara Kathryn , RAHMAN, Attiq , RAMANJULU, Joshi M. , SEHON, Clark A , SINGHAUS, JR., Robert , ZHANG, Daohua
IPC分类号： C07D403/12 , C07D413/14 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D267/14 , C07D498/04 , C07D281/10 , A61P37/00 , A61P25/28 , A61P17/06 , A61P29/00 , A61K31/55
CPC分类号： A61K31/553 , A61K31/55 , C07D223/08 , C07D267/14 , C07D281/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A, L, and B are as defined herein, and methods of making and using the same.
摘要翻译： 公开了具有下式的化合物：其中X，Y，Z 1，Z 2，Z 3，Z 4，R 5，RA，m，A，L和B如本文所定义，及其制备和使用方法。
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公开(公告)号：EP3375780A1
公开(公告)日：2018-09-19
申请号：EP18152185.7
申请日：2014-02-14
发明人： BANDYOPADHYAY, Deepak , EIDAM, Patrick M. , GOUGH, Peter J. , HARRIS, Philip Anthony , JEONG, Jae U. , KANG, Jianxing , KING, Bryan Wayne , LAKDAWALA SHAH, Ami , MARQUIS, JR., Robert W. , LEISTER, Lara Kathryn , RAHMAN, Attiq , RAMANJULU, Joshi M. , SEHON, Clark A. , SINGHAUS, JR., Robert , ZHANG, Daohua
IPC分类号： C07D403/12 , C07D413/14 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D267/14 , C07D498/04 , C07D281/10 , A61P37/00 , A61P25/28 , A61P17/06 , A61P29/00 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , C07D223/08
摘要： Disclosed is a compound which is
or a tautomer thereof or a salt thereof, pharmaceutical compositions comprising said compound or a tautomer thereof or a pharmaceutically acceptable salt thereof, and the use in the treatment of diseases/disorders which are likely to be regulated at least in part by programmed necrosis, apoptosis or the production of inflammatory cytokines.-
公开(公告)号：EP2956452B1
公开(公告)日：2018-03-21
申请号：EP14705891.1
申请日：2014-02-14
发明人： BANDYOPADHYAY, Deepak , EIDAM, Patrick M. , GOUGH, Peter J. , HARRIS, Philip Anthony , JEONG, Jae U. , KANG, Jianxing , KING, Bryan Wayne , LAKDAWALA SHAH, Ami , MARQUIS, JR., Robert W. , LEISTER, Lara Kathryn , RAHMAN, Attiq , RAMANJULU, Joshi M. , SEHON, Clark A , SINGHAUS, JR., Robert , ZHANG, Daohua
IPC分类号： C07D403/12 , C07D413/14 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D267/14 , C07D498/04 , C07D281/10 , A61P37/00 , A61P25/28 , A61P17/06 , A61P29/00 , A61K31/55
CPC分类号： A61K31/553 , A61K31/55 , C07D223/08 , C07D267/14 , C07D281/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A, L, and B are as defined herein, and methods of making and using the same.
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