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公开(公告)号：EP3359532A1
公开(公告)日：2018-08-15
申请号：EP16784966.0
申请日：2016-10-06
发明人： CALLAHAN, James Francis , KERNS, Jeffrey K. , LI, Peng , LI, Tindy , MCCLELAND, Brent W. , NIE, Hong , PERO, Joseph E. , DAVIES, Thomas Glanmor , GRAZIA CARR, Maria , GRIFFITHS-JONES, Charlotte Mary , HEIGHTMAN, Thomas Daniel , NORTON, David , VERDONK, Marinus Leendert , WOOLFORD, Alison Jo-Anne , WILLEMS, Hendrika Maria Gerarda
IPC分类号： C07D401/14 , C07D401/12 , C07D401/10 , C07D401/06 , C07D401/04 , A61K31/41 , A61K31/4196 , A61K31/445
CPC分类号： C07D515/14 , A61K9/0019 , A61K9/0053 , A61K9/0078 , A61P11/00 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/08 , C07D413/14 , C07D417/14
摘要： methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：EP3307719A1
公开(公告)日：2018-04-18
申请号：EP16730010.2
申请日：2016-06-15
发明人： KERNS, Jeffrey K. , LI, Tindy , YAN, Hongxing , HEIGHTMAN, Thomas Daniel , WOOLFORD, Alison Jo-Anne , GRIFFITHS-JONES, Charlotte Mary , WILLEMS, Hendrika Maria Gerarda
IPC分类号： C07D249/18 , A61K31/4192 , A61P11/00 , A61P25/00
CPC分类号： C07D249/18 , A61P11/00
摘要： The present invention relates to aryl analogs Formula (I), pharmaceutical compositions containing them and their use as Nrf2 regulators.
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公开(公告)号：EP3307739B1
公开(公告)日：2020-10-07
申请号：EP16810994.0
申请日：2016-06-15
发明人： KERNS, Jeffrey K , CALLAHAN, James Francis , YAN, Hongxing , HEIGHTMAN, Thomas Daniel , GRIFFITHS-JONES, Charlotte Mary , WOOLFORD, Alison Jo-Anne , LI, Tindy , LAKDAWALA SHAH, Ami , DAVIS, Roderick S. , NORTON, David , GOODWIN, Nicole Cathleen , JIN, Yun , HAMILTON, Paris L. , BOEHM, Jeffrey Charles
IPC分类号： C07D417/10 , C07D403/10 , C07D249/04 , C07D249/18 , C07C15/16 , A61P25/00 , A61P11/00 , A61P27/00 , A61P9/00 , A61P35/00 , A61P37/00 , A61K31/5365
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公开(公告)号：EP3307739A1
公开(公告)日：2018-04-18
申请号：EP16810994.0
申请日：2016-06-15
发明人： KERNS, Jeffrey K , CALLAHAN, James Francis , YAN, Hongxing , HEIGHTMAN, Thomas Daniel , GRIFFITHS-JONES, Charlotte Mary , WOOLFORD, Alison Jo-Anne , LI, Tindy , LAKDAWALA SHAH, Ami , DAVIS, Roderick S. , NORTON, David , GOODWIN, Nicole Cathleen , JIN, Yun , HAMILTON, Paris L. , BOEHM, Jeffrey Charles
IPC分类号： C07D417/10 , C07D403/10 , C07D249/04 , C07D249/18 , C07C15/16
摘要： The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：EP3083614A1
公开(公告)日：2016-10-26
申请号：EP14827868.2
申请日：2014-12-17
发明人： BOEHM, Jeffrey Charles , DAVIES, Thomas Glanmor , WOOLFORD, Alison Jo-anne , GRIFFITHS-JONES, Charlotte Mary , WILLEMS, Hendrika Maria Gerarda , NORTON, David , SAXTY, Gordon , HEIGHTMAN, Thomas Daniel , LI, Tindy , KERNS, Jeffrey K. , DAVIS, Roderick S. , YAN, Hongxing
IPC分类号： C07D417/10
摘要： The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
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公开(公告)号：EP3782996A1
公开(公告)日：2021-02-24
申请号：EP20200207.7
申请日：2016-06-15
发明人： KERNS, Jeffrey K , CALLAHAN, James Francis , YAN, Hongxing , HEIGHTMAN, Thomas Daniel , GRIFFITHS-JONES, Charlotte Mary , WOOLFORD, Alison Jo-Anne , LI, Tindy , LAKDAWALA SHAH, Ami , DAVIS, Roderick S. , NORTON, David , GOODWIN, Nicole Cathleen , JIN, Yun , HAMILTON, Paris L. , BOEHM, Jeffrey Charles
IPC分类号： C07D417/10 , C07D403/10 , C07D249/04 , C07D249/18 , C07C15/16 , A61P25/00 , A61P11/00 , A61P27/00 , A61P9/00 , A61P35/00 , A61P37/00 , A61K31/5365
摘要： The present invention relates to compositions comprising the compounds of formula (I) for their use as NRF2 regulators
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公开(公告)号：EP3083614B1
公开(公告)日：2020-01-15
申请号：EP14827868.2
申请日：2014-12-17
发明人： BOEHM, Jeffrey Charles , DAVIES, Thomas Glanmor , WOOLFORD, Alison Jo-anne , GRIFFITHS-JONES, Charlotte Mary , WILLEMS, Hendrika Maria Gerarda , NORTON, David , SAXTY, Gordon , HEIGHTMAN, Thomas Daniel , LI, Tindy , KERNS, Jeffrey K. , DAVIS, Roderick S. , YAN, Hongxing
IPC分类号： C07D417/10 , A61P11/00 , A61K9/00 , C07D405/12 , C07D401/12 , A61K31/472 , A61K31/4725 , C07D513/04 , C07D419/14
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公开(公告)号：EP3371167A1
公开(公告)日：2018-09-12
申请号：EP16784575.9
申请日：2016-10-06
发明人： CALLAHAN, James Francis , KERNS, Jeffrey K. , LI, Tindy , MCCLELAND, Brent W. , NIE, Hong , PERO, Joseph E. , DAVIES, Thomas Glanmor , HEIGHTMAN, Thomas Daniel , GRIFFITHS-JONES, Charlotte Mary , HOWARD, Steven , NORTON, David , VERDONK, Marinus Leendert , WOOLFORD, Alison Jo-Anne
IPC分类号： C07D401/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , A61K31/41 , A61K31/4196 , A61K31/445
CPC分类号： C07D231/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D403/14
摘要： methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
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公开(公告)号：EP3555068B1
公开(公告)日：2020-12-02
申请号：EP17818632.6
申请日：2017-12-11
发明人： BOEHM, Jeffrey Charles , DAVIS, Roderick S. , GOODWIN, Nicole Cathleen , KERNS, Jeffrey K. , LI, Tindy , YAN, Hongxing
IPC分类号： C07D403/12 , C07D403/10 , A61P11/00 , A61P9/04 , A61K31/551
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