公开(公告)号：EP1032669B1

公开(公告)日：2006-02-08

申请号：EP98965170.8

申请日：1998-11-16

申请人： Glaxosmithkline Biologicals S.A.

发明人： BRUCK, Claudine ,  BOLLEN, Alex ,  JACOBS, Paul ,  MASSAER, Marc

IPC分类号： C12N15/12 ,  C07K14/435 ,  A61K39/35

CPC分类号： C07K14/43531 ,  C12N9/6472

摘要： The present invention provides a novel treatment for allergy comprising the provision of a recombinant allergen with reduced enzymatic activity. Vaccines comprising said mutant allergens stimulate a Th1-type immune response in allergic or naïve individuals, thereby reducing the potential for an allergic response upon contact with wild-type allergen. Preferably said allergen is DerP1.