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1.发明授权SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS 有权取代的双环AZA-杂环和物作为沉默调节蛋白调节剂
公开(公告)号：EP2768509B1
公开(公告)日：2017-03-22
申请号：EP12842273.0
申请日：2012-10-19
申请人： GlaxoSmithKline LLC
IPC分类号： C07D487/04 , C07D519/00 , A61K31/535 , A61P3/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D491/107 , C07D495/10 , C07D519/00 , A61K2300/00 , A61K31/56
摘要： Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
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2.发明公开SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS 有权取代的双环AZA-杂环和物作为沉默调节蛋白调节剂
公开(公告)号：EP2768509A1
公开(公告)日：2014-08-27
申请号：EP12842273.0
申请日：2012-10-19
申请人： Glaxosmithkline LLC
IPC分类号： A61K31/535
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D491/107 , C07D495/10 , C07D519/00 , A61K2300/00 , A61K31/56
摘要： Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
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