公开(公告)号：EP1799639A1

公开(公告)日：2007-06-27

申请号：EP05784869.9

申请日：2005-07-26

申请人： Glenmark Pharmaceuticals S.A.

发明人： THOMAS, Abraham 303, Kavita Apartments, 3rd Floor ,  GOPALAN, Balasubramanian Flat No. 54 Block B-3 ,  LINGAM, Prasada, Rao, V., S. Flat No. 101 ,  SHAH, Daisy, Manish Padmashree Building, 1st

IPC分类号： C07D207/16 ,  A61K31/4015 ,  A61K31/4025 ,  C07D207/32 ,  C07D207/34 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07C271/24 ,  C07C309/66 ,  C07C237/24 ,  C07C255/46 ,  C07C255/31 ,  C07C259/08 ,  C07C275/28

CPC分类号： C07D235/06 ,  C07C271/24 ,  C07C309/66 ,  C07C2601/08 ,  C07C2601/10 ,  C07D207/16 ,  C07D207/325 ,  C07D207/34 ,  C07D209/08 ,  C07D209/42 ,  C07D209/44 ,  C07D211/62 ,  C07D217/04 ,  C07D231/12 ,  C07D233/54 ,  C07D233/68 ,  C07D233/90 ,  C07D233/95 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D277/04 ,  C07D295/135 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

摘要： The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: (I) wherein Y is -S(O)m, -CH2-, CHF, or -CF2; m is 0, 1, or 2; X is a bond, C1-C5 alkyl (e.g., -CH2-), or -C(=0)-; the dotted line [----] in the carbocyclic ring represents an optional double bond; R1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroarylalkyl, CN, -COOR3, CONR3R4, -OR3, -NR3R4, or NR3COR3; R2 is hydrogen, cyano, COOH, or an isostere of a carboxylic acid (such as SO3H, CONOH, B(OH)2, PO3R3R4, SO2NR3R4, tetrazole, -COOR3, -CONR3R4, NR3COR4, or -COOCOR3).