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公开(公告)号：EP3023497A1
公开(公告)日：2016-05-25
申请号：EP15162049.9
申请日：2006-11-17
IPC分类号： C12N15/13 , A61K39/395 , A61P19/00 , A61P35/00 , A61P37/02 , C07K14/705 , C07K14/78 , C07K16/28 , C12N15/63 , C12N5/10 , C12P21/08
CPC分类号： C07K16/2842 , A61K39/3955 , A61K47/6849 , A61K2039/505 , C07K14/7055 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/6893 , G01N2333/7055
摘要： The invention relates to anti-α2 integrin antibodies and their uses. Humanized antibodies are disclosed that bind to the I domain of α2 integrin and inhibit the interaction of α2β1 integrin with collagen. Also disclosed are therapeutic uses of anti-α2 integrin antibodies in treating α2β1-mediated disorders, including anti-α2 integrin antibodies that bind to α2 integrin without activating platelets.
摘要翻译： 本发明涉及抗±2整联蛋白抗体及其用途。 公开了与±2整联蛋白的I结构域结合并抑制±2β1整联蛋白与胶原蛋白相互作用的人源化抗体。 还公开了抗±2整联蛋白抗体治疗±2,21介导的病症的治疗用途，包括结合±2整联蛋白而不激活血小板的抗±2整联蛋白抗体。
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公开(公告)号：EP1948798B1
公开(公告)日：2015-04-01
申请号：EP06804739.8
申请日：2006-11-17
IPC分类号： C12N15/13 , A61K39/395 , A61P19/00 , A61P35/00 , A61P37/02 , C07K14/705 , C07K14/78 , C07K16/28 , C12N15/63 , C12N5/10 , C12P21/08 , G01N33/53 , G01N33/543 , G01N33/566
CPC分类号： C07K16/2842 , A61K39/3955 , A61K47/6849 , A61K2039/505 , C07K14/7055 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/6893 , G01N2333/7055
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公开(公告)号：EP1948798A1
公开(公告)日：2008-07-30
申请号：EP06804739.8
申请日：2006-11-17
IPC分类号： C12N15/13 , A61K39/395 , A61P19/00 , A61P35/00 , A61P37/02 , C07K14/705 , C07K14/78 , C07K16/28 , C12N15/63 , C12N5/10 , C12P21/08 , G01N33/53 , G01N33/543 , G01N33/566
CPC分类号： C07K16/2842 , A61K39/3955 , A61K47/6849 , A61K2039/505 , C07K14/7055 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/6893 , G01N2333/7055
摘要： The invention relates to anti-α2 integrin antibodies and their uses. Humanized antibodies are disclosed that bind to the I domain of α2 integrin and inhibit the interaction of α2&bgr;1 integrin with collagen. Also disclosed are therapeutic uses of anti-α2 integrin antibodies in treating α2&bgr;1-mediated disorders, including anti-α2 integrin antibodies that bind to α2 integrin without activating platelets.
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公开(公告)号：EP2245069B1
公开(公告)日：2014-06-18
申请号：EP09703856.6
申请日：2009-01-22
发明人： LAZARIDES, Elias , WOODS, Catherine , FAN, Xiaomin , HOU, Samuel , MOTTL, Harald , BLEIN, Stanislas , BERTSCHINGER, Martin
IPC分类号： C07K16/36 , C12N15/13 , A61K39/395 , A61P7/02
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP2245069A1
公开(公告)日：2010-11-03
申请号：EP09703856.6
申请日：2009-01-22
发明人： LAZARIDES, Elias , WOODS, Catherine , FAN, Xiaomin , HOU, Samuel , MOTTL, Harald , BLEIN, Stanislas , BERTSCHINGER, Martin
IPC分类号： C07K16/36 , C12N15/13 , A61K39/395 , A61P7/02
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure relates to humanized antibodies or binding fragments thereof specific for human von Willebrand factor (vWF), methods for their preparation and use, including methods for treating vWF mediated diseases or disorders.
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