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12 条记录 (耗时 0.016 秒)

    ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS
    1.
    发明公开
    ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS 有权
    作为TRPA1调节剂的异噻唑基嘧啶二酮衍生物

    公开(公告)号：EP2411397A1

    公开(公告)日：2012-02-01

    申请号：EP10716049.1

    申请日：2010-03-22

    申请人： Glenmark Pharmaceuticals S.A.

    发明人： KUMAR, Sukeerthi ,  THOMAS, Abraham ,  MARGAL, Sanjay ,  KHAIRATKAR-JOSHI, Neelima ,  MUKHOPADHYAY, Indranil

    IPC分类号： C07D513/04 ,  A61K31/429 ,  A61K31/519 ,  A61P29/00

    CPC分类号： C07D513/04

    摘要： The present invention is related to novel isothiazolo[3,4-d] pyrimidinedione and isothiazolo[5,4-d] pyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

    摘要翻译： 本发明涉及作为TRPA（瞬时受体电位亚家族A）调节剂的新型异噻唑并[3,4-d]嘧啶二酮和异噻唑并[5,4-d]嘧啶二酮衍生物。 特别地，本文所述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病，病况和/或病症。 本文还提供了用于制备本文所述化合物的方法，其合成中使用的中间体，其药物组合物以及用于治疗或预防由TRPA1调节的疾病，病况和/或病症的方法。

    THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS
    4.
    发明公开
    THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS 有权
    作为TRPA1调节剂的噻吩并嘧啶二酮衍生物

    公开(公告)号：EP2411396A2

    公开(公告)日：2012-02-01

    申请号：EP10751712.0

    申请日：2010-03-23

    申请人： Glenmark Pharmaceuticals S.A.

    发明人： KUMAR, Sukeerthi ,  THOMAS, Abraham ,  WAGHMARE, Nayan, Taterao ,  MARGAL, Sanjay ,  KHAIRATKAR-JOSHI, Neelima ,  MUKHOPADHYAY, Indranil

    IPC分类号： C07D495/04 ,  A61K31/381 ,  A61P29/00

    CPC分类号： A61K31/519 ,  A61K45/06 ,  C07D495/04

    摘要： The present invention is related to novel thienopyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl.

    摘要翻译： 本发明涉及作为TRPA（瞬时受体电位亚家族A）调节剂的新型噻吩并嘧啶二酮衍生物。 特别地，本文描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病，病况和/或病症。 本文还提供制备本文所述化合物的方法，其合成中使用的中间体，其药物组合物以及治疗或预防由TRPA1调节的疾病，病况和/或病症的方法。

    FUROPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS
    7.
    发明公开
    FUROPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS 有权
    作为TRPA1调节剂的呋喃并嘧啶二酮衍生物

    公开(公告)号：EP2411395A1

    公开(公告)日：2012-02-01

    申请号：EP10716050.9

    申请日：2010-03-22

    申请人： Glenmark Pharmaceuticals S.A.

    发明人： CHAUDHARI, Sachin, Sundarlal ,  THOMAS, Abraham ,  PATIL, Nisha, Parag ,  KHAIRATKAR-JOSHI, Neelima ,  MUKHOPADHYAY, Indranil

    IPC分类号： C07D491/048 ,  A61K31/34 ,  A61K31/519 ,  A61P29/00

    CPC分类号： A61K31/519 ,  A61K45/06 ,  C07D495/04

    摘要： The present invention is related to novel furopyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl. (Formula I) (I)

    摘要翻译： 本发明涉及作为TRPA（瞬时受体电位亚家族A）调节剂的新型呋喃并嘧啶二酮衍生物。 特别地，本文描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病，病况和/或病症。 本文还提供制备本文所述化合物的方法，其合成中使用的中间体，其药物组合物以及治疗或预防由TRPA1调节的疾病，病况和/或病症的方法。 （式I）（I）