公开(公告)号：EP2595971A1

公开(公告)日：2013-05-29

申请号：EP11743775.6

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07D275/06 ,  C07D291/06 ,  C07C215/54 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255

CPC分类号： C07D275/06 ,  A61K31/137 ,  A61K31/455 ,  C07B2200/07 ,  C07C55/02 ,  C07C55/08 ,  C07C55/20 ,  C07C57/15 ,  C07C63/08 ,  C07C63/36 ,  C07C65/11 ,  C07C215/54 ,  C07D213/80 ,  C07D239/545 ,  C07D291/06

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)- phenol (component a) and at least one acid component (b1 ) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

摘要翻译： 3-（3-二甲基氨基-1-乙基-2-甲基 - 丙基） - 苯酚（组分a）和至少一种酸组分（b1）或至少一种酸组分（b2）的盐或共结晶，其中盐 组分（a）和组分（b2）的共结晶以结晶和/或无定形形式存在，包含所述盐或共结晶的药物组合物，以及通过施用有效量的所述有效量的所述有机溶剂治疗有需要的受试者的疼痛的方法 盐或共晶。

公开(公告)号：EP3650439A1

公开(公告)日：2020-05-13

申请号：EP19214270.1

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07C215/54 ,  C07D275/06 ,  C07D291/06 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255 ,  A61P25/04 ,  C07C57/145

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

公开(公告)号：EP3800179A1

公开(公告)日：2021-04-07

申请号：EP20204993.8

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07C215/54 ,  C07D275/06 ,  C07D291/06 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

公开(公告)号：EP3656765A1

公开(公告)日：2020-05-27

申请号：EP19214275.0

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07D275/06 ,  C07D291/06 ,  C07C215/54 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

公开(公告)号：EP3636629A1

公开(公告)日：2020-04-15

申请号：EP19206638.9

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07C215/54 ,  C07D275/06 ,  C07D291/06 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

公开(公告)号：EP3597628A1

公开(公告)日：2020-01-22

申请号：EP19191640.2

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07C215/54 ,  C07D275/06 ,  C07D291/06 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255 ,  A61P25/04

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

公开(公告)号：EP3287447A1

公开(公告)日：2018-02-28

申请号：EP17191453.4

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07D275/06 ,  C07D291/06 ,  C07C215/54 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255

CPC分类号： C07D275/06 ,  A61K31/137 ,  A61K31/455 ,  C07B2200/07 ,  C07C55/02 ,  C07C55/08 ,  C07C55/20 ,  C07C57/15 ,  C07C63/08 ,  C07C63/36 ,  C07C65/11 ,  C07C215/54 ,  C07D213/80 ,  C07D239/545 ,  C07D291/06

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

摘要翻译： 本发明涉及3-（3-二甲基氨基-1-乙基-2-甲基丙基） - 苯酚（组分a）和至少一种酸组分（b1）或至少一种酸组分（b2）的盐或共结晶， 其中组分（a）和组分（b2）的盐或共结晶以结晶和/或无定形形式存在，包含所述盐或共结晶的药物以及所述盐或共结晶用于治疗疼痛。