公开(公告)号：EP3650439A1

公开(公告)日：2020-05-13

申请号：EP19214270.1

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07C215/54 ,  C07D275/06 ,  C07D291/06 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255 ,  A61P25/04 ,  C07C57/145

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

公开(公告)号：EP2477960A1

公开(公告)日：2012-07-25

申请号：EP10757159.8

申请日：2010-09-13

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  BUSCHMANN, Helmut, Heinrich

IPC分类号： C07C217/74 ,  A61K31/135 ,  A61P25/00

CPC分类号： C07C217/74 ,  C07B2200/13

摘要： The present invention relates to crystalline modifications of (1R,3R,6R)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol, (1S,3S,6S)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol and mixtures thereof, pharmaceutical compositions and medicaments comprising these modifications, the use of these modifications as well as to a process for the enrichment of (1R,3R,6R)- or (1S,3S,6S)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol.

公开(公告)号：EP1851192A1

公开(公告)日：2007-11-07

申请号：EP06707124.1

申请日：2006-02-21

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  BUSCHMANN, Helmut ,  FISCHER, Andreas ,  HELL, Wolfgang ,  LISCHKE, Dagmar

IPC分类号： C07C217/54 ,  A61K31/135

CPC分类号： C07C217/74 ,  C07C217/54 ,  C07C2601/14

摘要： This invention relates to solid crystalline forms of (1 RS,3RS,6RS)-6- Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1 ,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.

摘要翻译： 本发明涉及（1RS，3RS，6RS）-6-二甲基氨基甲基-1-（3-甲氧基 - 苯基）环己烷-1,3-二醇盐酸盐（1）的固体形式，其制备方法1，使用方法 1，使用1作为止痛剂和药物组合物，其包含1。

公开(公告)号：EP3173400A1

公开(公告)日：2017-05-31

申请号：EP16203848.3

申请日：2008-12-05

申请人： Grünenthal GmbH

发明人： GRUSS, Michael

IPC分类号： C07C215/54 ,  A61K31/137 ,  A61P25/04

摘要： Die Erfindung betrifft kristalline Modifikationen von (1 R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol, pharmazeutische Zusammensetzungen, welche diese Modifikationen enthalten, sowie deren Verwendung.

摘要翻译： 本发明涉及（1R，2R）-3-（3-二甲基氨基-1-乙基-2-甲基 - 丙基） - 苯酚的晶体改性，含有这些改性的药物组合物及其用途。

公开(公告)号：EP2797923B1

公开(公告)日：2016-09-07

申请号：EP12798311.2

申请日：2012-12-11

申请人： Grünenthal GmbH

发明人： KLUGE, Stefan ,  GRUSS, Michael ,  SIEBER, Andreas

IPC分类号： C07D491/107 ,  A61K31/407 ,  A61P29/00

CPC分类号： C07D491/052 ,  C07D491/107

公开(公告)号：EP2595971A1

公开(公告)日：2013-05-29

申请号：EP11743775.6

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07D275/06 ,  C07D291/06 ,  C07C215/54 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255

CPC分类号： C07D275/06 ,  A61K31/137 ,  A61K31/455 ,  C07B2200/07 ,  C07C55/02 ,  C07C55/08 ,  C07C55/20 ,  C07C57/15 ,  C07C63/08 ,  C07C63/36 ,  C07C65/11 ,  C07C215/54 ,  C07D213/80 ,  C07D239/545 ,  C07D291/06

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)- phenol (component a) and at least one acid component (b1 ) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

摘要翻译： 3-（3-二甲基氨基-1-乙基-2-甲基 - 丙基） - 苯酚（组分a）和至少一种酸组分（b1）或至少一种酸组分（b2）的盐或共结晶，其中盐 组分（a）和组分（b2）的共结晶以结晶和/或无定形形式存在，包含所述盐或共结晶的药物组合物，以及通过施用有效量的所述有效量的所述有机溶剂治疗有需要的受试者的疼痛的方法 盐或共晶。

公开(公告)号：EP1881956B1

公开(公告)日：2009-05-13

申请号：EP06776325.0

申请日：2006-07-20

申请人： Grünenthal GmbH

发明人： SZELAGIEWICZ, Martin ,  HELL, Wolfgang ,  VON RAUMER, Markus ,  DE PAUL, Susan, Margaret ,  BERGHAUSEN, Jörg ,  GRUSS, Michael

IPC分类号： C07C215/64

CPC分类号： C07C215/64 ,  C07B2200/13 ,  C07C2601/14

摘要： 3-[2-(Dimethylamino)methyl(cyclohex-1-yl)]phenol maleate is an analgesic with a very good action. The crystalline form A has proven to be very stable both chemically and physically and is particularly suitable for the production of the active principle and of pharmaceutical compositions.

公开(公告)号：EP3656765A1

公开(公告)日：2020-05-27

申请号：EP19214275.0

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07D275/06 ,  C07D291/06 ,  C07C215/54 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

公开(公告)号：EP3636629A1

公开(公告)日：2020-04-15

申请号：EP19206638.9

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07C215/54 ,  C07D275/06 ,  C07D291/06 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

公开(公告)号：EP3597628A1

公开(公告)日：2020-01-22

申请号：EP19191640.2

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07C215/54 ,  C07D275/06 ,  C07D291/06 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255 ,  A61P25/04

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.