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公开(公告)号：EP1751101B1
公开(公告)日：2012-11-14
申请号：EP05742882.3
申请日：2005-05-17
申请人： Grünenthal GmbH
发明人： MERLA, Beatrix , SUNDERMANN, Corinna , JAGUSCH, Utz-Peter , ENGLBERGER, Werner , HENNIES, Hagen-Heinrich , KÖGEL, Babette-Yvonne
IPC分类号： C07D207/34
CPC分类号： C07D207/34
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2.发明授权1,3-DISUBSTITUIERTE 4-METHYL-1 H-PYRROL-2-CARBONSÄUREAMIDE UND IHRE VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN 有权1,3-二取代-4-甲基-1H-吡咯-2-羧酰胺和其药用的制造使用
公开(公告)号：EP2035375B1
公开(公告)日：2011-01-19
申请号：EP07725929.9
申请日：2007-06-08
申请人： Grünenthal GmbH
发明人： OBERBÖRSCH, Stefan , Dr. SUNDERMANN, Bernd , SUNDERMANN, Corinna , Dr. BIJSTERVELD, Edward , HENNIES, Hagen-Heinrich
IPC分类号： C07D207/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides of the general formula I, methods for their preparation, medicaments comprising these compounds, and the use thereof for the manufacture of medicaments.
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公开(公告)号：EP1753757A1
公开(公告)日：2007-02-21
申请号：EP05747410.8
申请日：2005-05-17
申请人： Grünenthal GmbH
发明人： MERLA, Beatrix , SUNDERMANN, Corinna , JAGUSCH, Utz-Peter , ENGLBERGER, Werner , HENNIES, Hagen-Heinrich
IPC分类号： C07D413/14 , C07D403/06 , C07D401/14 , C07D401/06 , A61K31/5377 , A61K31/496 , A61K31/4453 , A61P25/04
CPC分类号： C07D401/14 , C07D401/06 , C07D403/06
摘要： The invention relates to substituted 2,5-diaminomethyl-1 H-pyrroles, to a method for the production thereof, to medicaments containing said compounds and to the utilization of these compounds for the production of medicaments.
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公开(公告)号：EP1751088A1
公开(公告)日：2007-02-14
申请号：EP05738450.5
申请日：2005-05-06
申请人： Grünenthal GmbH
IPC分类号： C07C231/02 , C07C235/80 , A61K31/16 , A61P25/04 , A61P29/00
CPC分类号： C07C235/74 , C07C235/80
摘要： Novel cyclohexyl-1,4-diamine compounds corresponding to formula I: methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical formulations and related methods of treating or inhibiting certain diseases or conditions.
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5.发明公开SUBSTITUIERTE 1,4,8-TRIAZASPIRO¬4.5|DECAN-2-ON-VERBINDUNGEN ZUR BEHANDLUNG VON FETTSUCHT 有权取代的1,4,8-三氮杂螺[4.5癸-2-酮化合物FOR治疗肥胖
公开(公告)号：EP1730147A1
公开(公告)日：2006-12-13
申请号：EP05716285.1
申请日：2005-03-22
申请人： Grünenthal GmbH
发明人： SUNDERMANN, Corinna , SUNDERMANN, Bernd , OBERBÖRSCH, Stefan , ENGLBERGER, Werner , HENNIES, Hagen-Heinrich
IPC分类号： C07D471/10 , A61K31/435 , A61P3/00
CPC分类号： C07D471/10
摘要： The invention relates to the substituted 1,4,8-triazaspiro[4.5]decan-2-on compounds of formula (I), to methods for producing the same, to drugs containing said compounds and to the use of said compounds for producing drugs.
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公开(公告)号：EP1549650B1
公开(公告)日：2006-03-22
申请号：EP03807842.4
申请日：2003-10-06
申请人： Grünenthal GmbH
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00 , A61P35/00 , C07D235/00 , C07D221/00
CPC分类号： C07D471/04
摘要： The invention relates to substituted C-imidazo[1,2-a]pyridin-3-yl-methylamines and the physiologically acceptable salts thereof, methods for the production thereof, medicaments containing said compounds, and the use of substituted C-imidazo[1,2-a]pyridin-3-yl-methylamines for producing medicaments.
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公开(公告)号：EP1581490A1
公开(公告)日：2005-10-05
申请号：EP03785875.0
申请日：2003-12-18
申请人： Grünenthal GmbH
发明人： MERLA, Beatrix , SUNDERMANN, Corinna , JAGUSCH, Utz-Peter , ENGLBERGER, Werner , HENNIES, Hagen-Heinrich , KÖGEL, Babette-Yvonne
IPC分类号： C07D207/40 , A61K31/40 , A61P25/04
CPC分类号： C07D207/34
摘要： The invention relates to substituted 5-aminomethyl-1H-pyrrole-2-carboxamides, to a method for the production thereof, to medicaments containing these compounds, and to the use of these compounds for producing medicaments.
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公开(公告)号：EP1581490B1
公开(公告)日：2011-01-26
申请号：EP03785875.0
申请日：2003-12-18
申请人： Grünenthal GmbH
发明人： MERLA, Beatrix , SUNDERMANN, Corinna , JAGUSCH, Utz-Peter , ENGLBERGER, Werner , HENNIES, Hagen-Heinrich , KÖGEL, Babette-Yvonne
IPC分类号： C07D207/40 , A61K31/40 , A61P25/04
CPC分类号： C07D207/34
摘要： The invention relates to substituted 5-aminomethyl-1H-pyrrole-2-carboxamides, to a method for the production thereof, to medicaments containing these compounds, and to the use of these compounds for producing medicaments.
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9.发明授权SUBSTITUIERTE AMINO-FURAN-2-YL-ESSIGSAURE- UND AMINO-THIEN-2-YL-ESSIGSAURE-DERIVATE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON MIGRAINE BZW. SCHMERZ 有权取代的氨基呋喃-2-基ESSIGSAURE-和氨基 - 噻吩基醋衍生物和它们用于治疗偏头痛或 PAIN
公开(公告)号：EP1341786B9
公开(公告)日：2009-08-05
申请号：EP01998547.2
申请日：2001-11-28
申请人： Grünenthal GmbH
IPC分类号： C07D409/12 , C07D407/12 , C07D405/12 , C07D307/68 , C07D307/42 , A61K31/443 , A61K31/4436 , A61K31/4155 , A61K31/341 , C07D307/54 , C07D333/24 , A61K31/44 , C07D333/28 , C07D307/56 , A61P29/02
CPC分类号： C07D307/56 , C07D307/54 , C07D307/68 , C07D333/24 , C07D405/12 , C07D409/12
摘要： The invention relates to substituted aminofuran-2-yl-acetic acid derivatives and substituted aminothien-2-yl-acetic acid derivatives of general formulae (I-A) and (I-B). The invention also relates to a method for the production thereof, medicaments containing the same, the use of said compounds for producing medicaments for treating, inter alia, pain and migraines, and pharmaceutical compositions containing the same.
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10.发明授权
公开(公告)号：EP1730144B1
公开(公告)日：2009-06-10
申请号：EP05716300.8
申请日：2005-03-22
申请人： Grünenthal GmbH
发明人： SUNDERMANN, Corinna , SUNDERMANN, Bernd , OBERBÖRSCH, Stefan , ENGLBERGER, Werner , HENNIES, Hagen-Heinrich
IPC分类号： C07D471/04 , A61K31/437 , A61P25/24
CPC分类号： C07D471/10
摘要： The invention relates to substituted 1,4,8,-triazaspiro[4.5]decan-2-one compounds, to methods for producing said compounds, to medicaments containing said compounds and to the use of the latter for producing medicaments.
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