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公开(公告)号：EP2726499B1
公开(公告)日：2017-11-15
申请号：EP11868565.0
申请日：2011-07-25
发明人： KIM, Se-Ho , HONG, Kwang-Won , SHIN, Yong-Won , CHANG, Ki Hwan , KIM, Min-Soo , IM, Jung-Ae
IPC分类号： C07K14/02 , A61K39/29 , A61K39/42 , C07K16/08 , C12N15/36 , C07K17/02 , C12N15/63 , C12N7/01 , C12N15/85 , A61P31/20
CPC分类号： C07K14/005 , A01K67/027 , A01K2207/05 , A01K2227/105 , A01K2267/0337 , A61K39/00 , A61K39/292 , A61K2039/53 , C07K16/082 , C07K2317/34 , C07K2317/76 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12N2730/10151
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2.发明公开EPITOPE AND ITS USE OF HEPATITIS B VIRUS SURFACE ANTIGEN 有权EPITOPEFÜREIN HEPATITIS-B-VIRUS-OBERFLÄCHENENTIGENUND IHR VERWENDUNG
公开(公告)号：EP2726499A1
公开(公告)日：2014-05-07
申请号：EP11868565.0
申请日：2011-07-25
发明人： KIM, Se-Ho , HONG, Kwang-Won , SHIN, Yong-Won , CHANG, Ki Hwan , KIM, Min-Soo , IM, Jung-Ae
IPC分类号： C07K14/02 , C07K17/02 , C12N15/36 , C12N15/63 , C12N7/01 , C12N15/85 , A61K39/42 , A61P31/20
CPC分类号： C07K14/005 , A01K67/027 , A01K2207/05 , A01K2227/105 , A01K2267/0337 , A61K39/00 , A61K39/292 , A61K2039/53 , C07K16/082 , C07K2317/34 , C07K2317/76 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12N2730/10151
摘要： Disclosed are an epitope specific to hepatitis B virus (HBV) and use thereof. The disclosed epitope is a conservative position on which mutagenesis does not occur and, therefore, a composition including an antibody to the foregoing epitope or a vaccine composition including the epitope has very low possibility of causing degradation of curing efficacy due to HBV mutation, thus being very useful for HBV treatment.
摘要翻译： 公开了乙型肝炎病毒（HBV）特异性表位及其用途。 所公开的表位是其中不发生诱变的保守位置，因此包含上述表位抗体的组合物或包含该表位的疫苗组合物的组合物具有由于HBV突变导致治愈功效降低的可能性非常低 对HBV治疗非常有用。
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3.发明公开KIT FOR MEASURING TITER OF A PROTEIN COMPRISING HUMAN FC USING INDIRECT ELISA AND METHOD FOR MEASURING TITER OF A PROTEIN COMPRISING HUMAN FC USING THE SAME 审中-公开使用间接ELISA测定含有人FC的蛋白质的滴定度的试剂盒和使用相同的方法测定含有人FC的蛋白质的滴定度的试剂盒
公开(公告)号：EP3201626A1
公开(公告)日：2017-08-09
申请号：EP15845586.5
申请日：2015-09-30
发明人： SHIN, Yong Won , LEE, Juho , LIM, Jeong-Ae , CHANG, Ki Hwan , KIM, Min-Soo
摘要： Provided are a kit for measuring a titer of a human antibody, a humanized antibody, or a human Fc-fusion protein in human plasma or serum, and a method for measuring a titer of a human Fc-containing protein in human plasma or serum using the same, and more specifically, a kit for measuring a titer of human Fc-containing protein in human plasma or serum, the kit including a diluent for sample, a diluent for conjugate, and a cleansing solution and being used in analysis through an indirect enzyme-linked immunosorbent assay (indirect ELISA), and a method for measuring a titer of human Fc-containing protein in human plasma or serum using the same.
摘要翻译： 本发明提供一种用于测定人血浆或血清中的人抗体，人源化抗体或人Fc融合蛋白的效价的试剂盒以及使用人血浆或血清测定人Fc的蛋白质滴度的方法 相同，更具体地说，是用于测定人血浆或血清中含有人Fc的蛋白质滴度的试剂盒，该试剂盒包括样品稀释剂，偶联物稀释剂和清洁溶液，并用于通过间接分析 酶联免疫吸附测定法（间接ELISA），以及使用其测定人血浆或血清中含人Fc的蛋白质滴度的方法。
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公开(公告)号：EP3201626B1
公开(公告)日：2020-04-01
申请号：EP15845586.5
申请日：2015-09-30
发明人： SHIN, Yong Won , LEE, Juho , LIM, Jeong-Ae , CHANG, Ki Hwan , KIM, Min-Soo
IPC分类号： G01N33/543 , G01N33/68 , G01N33/53
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5.发明公开EPITOPES OF EPIDERMAL GROWTH FACTOR RECEPTOR SURFACE ANTIGEN AND USE THEREOF 审中-公开表皮生长因子受体表面抗原和使用抗原决定基
公开(公告)号：EP2832363A1
公开(公告)日：2015-02-04
申请号：EP13769431.1
申请日：2013-03-27
发明人： KIM, Se-Ho , HONG, Kwang-Won , CHANG, Ki Hwan , KIM, Min-Soo , LEE, Mi-Jung , WON, Jong-Hwa , HUR, Min-Kyu , CHO, Hyun-soo , YOO, Ji-Ho
IPC分类号： A61K38/17 , A61K38/16 , A61K39/395 , A61K48/00 , A61P35/00
CPC分类号： C07K16/3046 , A61K39/0005 , A61K39/0011 , A61K2039/53 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C12N15/1037
摘要： The present invention relates to epitopes of the epidermal growth factor receptor (EGFR) and the use thereof. The epitopes provided by the present invention are highly preserved, and located in the domain closely related to binding with an epidermal growth factor (EGF). Therefore, vaccine compositions comprising the epitopes or compositions comprising antibodies to the epitopes may efficiently block a signal transduction caused by binding of EGF and EGRF, and thus can be highly valuably used in treating various diseases such as cancer. An antibody bound to the epitopes of the present invention may efficiently inhibit binding of various EGFR ligands such as not only EGF but also TGF-a, AR, BTC, EPR and HB-EGF, with EGFR, and therefore can be used in treating various diseases resulting from an activation of EGFR caused by binding not only with EGF but also with other EGFR ligands.
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公开(公告)号：EP2832363B1
公开(公告)日：2018-09-19
申请号：EP13769431.1
申请日：2013-03-27
发明人： KIM, Se-Ho , HONG, Kwang-Won , CHANG, Ki Hwan , KIM, Min-Soo , LEE, Mi-Jung , WON, Jong-Hwa , HUR, Min-Kyu , CHO, Hyun-soo , YOO, Ji-Ho
CPC分类号： C07K16/3046 , A61K39/0005 , A61K39/0011 , A61K2039/53 , C07K16/2863 , C07K2317/10 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/567 , C07K2317/76 , C12N15/1037 , G01N33/57492 , G01N2333/71
摘要： The present invention relates to epitopes of the epidermal growth factor receptor (EGFR) and the use thereof. The epitopes provided by the present invention are highly preserved, and located in the domain closely related to binding with an epidermal growth factor (EGF). Therefore, vaccine compositions comprising the epitopes or compositions comprising antibodies to the epitopes may efficiently block a signal transduction caused by binding of EGF and EGRF, and thus can be highly valuably used in treating various diseases such as cancer. An antibody bound to the epitopes of the present invention may efficiently inhibit binding of various EGFR ligands such as not only EGF but also TGF-a, AR, BTC, EPR and HB-EGF, with EGFR, and therefore can be used in treating various diseases resulting from an activation of EGFR caused by binding not only with EGF but also with other EGFR ligands.
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7.发明授权
公开(公告)号：EP2483309B1
公开(公告)日：2016-08-17
申请号：EP09850100.0
申请日：2009-11-02
发明人： KIM, Se-Ho , CHANG, Ki Hwan , HONG, Kwang-Won , SHIN, Yong-Won , KIM, Min-Soo , LEE, Hae-Won , SHIN, Yong Nam , RYOO, Kyung Hwan , SEO, Dong Hyuck , WON, Jong-Hwa , HUR, Min-Kyu
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , C07K2317/565
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8.发明公开
公开(公告)号：EP2483309A1
公开(公告)日：2012-08-08
申请号：EP09850100.0
申请日：2009-11-02
发明人： KIM, Se-Ho , CHANG, Ki Hwan , HONG, Kwang-Won , SHIN, Yong-Won , KIM, Min-Soo , LEE, Hae-Won , SHIN, Yong Nam , RYOO, Kyung Hwan , SEO, Dong Hyuck
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , C07K2317/565
摘要： Provided are antibodies specifically binding to the epidermal growth factor receptor (EGFR) which are effective for the treatment of EGFR-mediated cancers.
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