公开(公告)号：EP3690053A1

公开(公告)日：2020-08-05

申请号：EP18862737.6

申请日：2018-09-20

申请人： Green Cross Corporation ,  Mogam Institute for Biomedical Research

发明人： KIM, So Ra ,  JUNG, Myung Eun ,  KIM, Min Jung ,  JO, Seung Hyun ,  HWANG, Sung Ho ,  KWAK, Hee Chun ,  LEE, Su Min ,  NAM, Hyun Ja

IPC分类号： C12N15/85 ,  C12N15/10 ,  C12N15/113 ,  C12N9/22 ,  C12N9/10 ,  C12N9/64 ,  A01K67/027

摘要： The present invention relates to a factor VIII or factor IX gene knockout rabbit, a method for preparing the same and a use thereof and, more particularly, to a transgenic rabbit whose factor VIII or factor IX gene has been knocked out through the CRISPR/Cas9 system, a method for preparing the same and a use thereof. According to the present invention, in the transgenic rabbit, whose factor VIII and/or factor IX gene has been knocked out, the functions of factor VIII and/or factor IX, which are proteins that perform critical functions for the development of hemophilia, are inhibited, such that the transgenic rabbit is useful for the development of hemophilia treatments.