公开(公告)号：EP1299415A1

公开(公告)日：2003-04-09

申请号：EP01984163.4

申请日：2001-07-12

申请人： Gryphon Therapeutics, Inc.

发明人： OFFORD, Robin ,  GAERTNER, Hubert ,  HARTLEY, Oliver

IPC分类号： C07K14/435 ,  C07K14/47 ,  C07K14/52 ,  A61K38/16 ,  A61K38/17 ,  A61K38/19

CPC分类号： C07K14/7158 ,  A61K38/00 ,  A61K47/60 ,  A61K47/62

摘要： Chemokine receptor modulators comprising a chemically modified carboxyl-terminus (C-terminus) and/or amino-terminus (N-terminus) for modulating potency and pharmacokinetic properties, and methods of production and use are disclosed. The compounds and methods of the invention are exemplified by novel N-terminal, C-terminal and N/C-terminal analogs of CC and CXC chemokines. The chemokine receptor modulator analogs of the invention are useful for the treatment of disorders involving the naturally occurring chemokine that the analogs of the invention antagonize, such as for the treatment of HIV and AIDS related disorders and for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, organ transplant rejection, and rheumatoid arthritis.