公开(公告)号：EP4194455A1

公开(公告)日：2023-06-14

申请号：EP21874399.5

申请日：2021-09-26

申请人： Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

发明人： WANG, Jiansong ,  FU, Zhifei ,  LUO, Zhibo ,  LUO, Miaorong ,  ZHANG, Yang ,  LI, Jian ,  CHEN, Shuhui ,  BAO, Yingxia ,  WANG, Wei ,  XIE, Zhoufan

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

摘要： Provided are crystal forms of compounds represented by formula(II)-formula (VIII) and formula (I)-fbrmula (VIII-1), a preparation method therefor and an application of the compounds and crystal forms in the preparation of a drug for treating a related disease.

公开(公告)号：EP3950688A1

公开(公告)日：2022-02-09

申请号：EP20782749.4

申请日：2020-04-03

申请人： Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory ,  Medshine Discovery Inc.

发明人： WANG, Jiansong ,  FU, Zhifei ,  LUO, Zhibo ,  LUO, Miaorong ,  ZHANG, Yang ,  CAI, Yalei ,  ZHU, Wu ,  LI, Jian ,  CHEN, Shuhui ,  BAO, Yingxia ,  WANG, Wei ,  XIE, Zhoufan

IPC分类号： C07D471/10 ,  C07D401/14 ,  C07D403/14 ,  A61K31/506 ,  A61P35/00

摘要： Disclosed are a series of compounds with a nitrogen-containing spiro structure and an application thereof in the preparation of an RET kinase inhibitor. Specifically, disclosed is a compound as shown in formula (II) or a pharmaceutically acceptable salt thereof.