公开(公告)号：EP3733190A1

公开(公告)日：2020-11-04

申请号：EP18896693.1

申请日：2018-12-28

申请人： Guangzhou Cellprotek Pharmaceutical Co., Ltd.

发明人： YAN, Guangmei ,  YIN, Wei ,  SHENG, Longxiang ,  LU, Bingzheng ,  HUANG, Yijun ,  LIN, Suizhen

IPC分类号： A61K31/568 ,  A61P9/10

摘要： Disclosed is the use of 5α-androst-3β,5,6β-triol and analogs and deuterated compounds thereof or pharmaceutically acceptable salts thereof in the preparation of drugs for treating the cerebral small vessel disease of patients. The cerebral small vessel disease is preferably brain microhemorrhages. The brain microhemorrhages refer to spontaneous brain microhemorrhages, drug-related brain microhemorrhages or traumatic brain microhemorrhages. The present invention confirms that these compounds significantly enhance the clearance of extravascular hemoglobin and can thus be used for treating cerebral small vessel disease.

公开(公告)号：EP3586873A1

公开(公告)日：2020-01-01

申请号：EP18757439.7

申请日：2018-02-06

申请人： Guangzhou Cellprotek Pharmaceutical Co., Ltd.

发明人： YAN, Guangmei ,  YIN, Wei ,  LI, Yuan ,  LU, Bingzheng ,  SHENG, Longxiang

IPC分类号： A61K45/00 ,  A61K31/416 ,  A61P25/28 ,  A61P9/10

摘要： Provided are applications of a hexokinase 2-specific inhibitor in preparing a medicament for preventing and treating acute central nervous system injury.