公开(公告)号：EP3733190A1

公开(公告)日：2020-11-04

申请号：EP18896693.1

申请日：2018-12-28

申请人： Guangzhou Cellprotek Pharmaceutical Co., Ltd.

发明人： YAN, Guangmei ,  YIN, Wei ,  SHENG, Longxiang ,  LU, Bingzheng ,  HUANG, Yijun ,  LIN, Suizhen

IPC分类号： A61K31/568 ,  A61P9/10

摘要： Disclosed is the use of 5α-androst-3β,5,6β-triol and analogs and deuterated compounds thereof or pharmaceutically acceptable salts thereof in the preparation of drugs for treating the cerebral small vessel disease of patients. The cerebral small vessel disease is preferably brain microhemorrhages. The brain microhemorrhages refer to spontaneous brain microhemorrhages, drug-related brain microhemorrhages or traumatic brain microhemorrhages. The present invention confirms that these compounds significantly enhance the clearance of extravascular hemoglobin and can thus be used for treating cerebral small vessel disease.

公开(公告)号：EP3586873A1

公开(公告)日：2020-01-01

申请号：EP18757439.7

申请日：2018-02-06

申请人： Guangzhou Cellprotek Pharmaceutical Co., Ltd.

发明人： YAN, Guangmei ,  YIN, Wei ,  LI, Yuan ,  LU, Bingzheng ,  SHENG, Longxiang

IPC分类号： A61K45/00 ,  A61K31/416 ,  A61P25/28 ,  A61P9/10

摘要： Provided are applications of a hexokinase 2-specific inhibitor in preparing a medicament for preventing and treating acute central nervous system injury.

公开(公告)号：EP4129299A1

公开(公告)日：2023-02-08

申请号：EP21760885.0

申请日：2021-02-26

申请人： Guangzhou Cellprotek Pharmaceutical Co., Ltd.

发明人： LU, Bingzheng ,  CHEN, Yupin ,  WANG, Yana ,  HUANG, Jiayu ,  HUANG, Chunhui ,  CHEN, Jiesi

IPC分类号： A61K31/568 ,  A61P31/14 ,  A61P11/00

摘要： Disclosed is use of 5α-androst-3β,5,6β-triol or an analogue, a deuterated compound or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of a pulmonary disease in a patient. These compounds can significantly inhibit the up-regulation of PFKFB3 expression, significantly inhibit the accumulation of lactate, significantly reduce vascular endothelial cell injury, significantly reduce alveolar epithelial cell injury, significantly inhibit alveolar septum thickening, significantly reduce alveolar damage, and thus can be used to treat diseases mediated by lung epithelial cell injury and/or vascular endothelial cell injury, such as in the lung.

公开(公告)号：EP3135288B1

公开(公告)日：2019-01-30

申请号：EP15783742.8

申请日：2015-04-14

申请人： Guangzhou Cellprotek Pharmaceutical Co., Ltd.

发明人： YIN, Wei ,  CHEN, Jiesi ,  YAN, Guangmei ,  LU, Bingzheng ,  ZHU, Wenbo ,  HU, Haiyan ,  QIU, Pengxin ,  HUANG, Yijun ,  ZHANG, Jingxia

IPC分类号： A61K31/56 ,  A61K31/565 ,  A61K31/575 ,  A61P25/00 ,  A61P7/10

公开(公告)号：EP3135288A1

公开(公告)日：2017-03-01

申请号：EP15783742.8

申请日：2015-04-14

申请人： Guangzhou Cellprotek Pharmaceutical Co., Ltd.

发明人： YIN, Wei ,  CHEN, Jiesi ,  YAN, Guangmei ,  LU, Bingzheng ,  ZHU, Wenbo ,  HU, Haiyan ,  QIU, Pengxin ,  HUANG, Yijun ,  ZHANG, Jingxia

IPC分类号： A61K31/56 ,  A61K31/565 ,  A61K31/575 ,  A61P25/00 ,  A61P7/10

CPC分类号： A61K31/56 ,  A61K31/565 ,  A61K31/575

摘要： Use of 5α-androstane-3β,5,6β-triol and analogs thereof in the preparation of a drug for the prophylaxis or treatment of an altitude sickness caused by hypobaric hypoxia is provided, so as to provide a new drug for the prophylaxis or treatment of an altitude sickness. Researches revealed that 5α-androstane-3β,5,6β-triol treatment can effectively reduce vasogenic edema of brain tissue of Macaca fascicularis caused by hypobaric hypoxia, reduce the increased cerebral water content, and protect from neuronal vacuolar degeneration caused by hypobaric hypoxia, therefore it can improve neurological dysfunctions caused by hypobaric hypoxia and is useful in prophylaxis or treatment of an altitude sickness.

摘要翻译： 提供了5± - 雄甾烷-3,2,5,6-二醇及其类似物在制备用于预防或治疗由低压缺氧引起的高原病的药物中的用途，以提供新的药物用于预防或 治疗高原病。 研究结果表明，5± - 雄甾烷-3,2,5,6-二酚治疗可有效降低由低压缺氧引起的猕猴属脑组织的血管性水肿，降低脑水含量，保护低压缺氧引起的神经元空泡变性， 因此可以改善由低压缺氧引起的神经功能障碍，可用于预防或治疗高原病。