公开(公告)号：EP4265606A1

公开(公告)日：2023-10-25

申请号：EP21909417.4

申请日：2021-12-21

申请人： Guangzhou Ocusun Ophthalmic Biotechnology Co., Ltd. ,  Ocusun Ophthalmic Pharmaceutical (Guangzhou) Co., Ltd.

发明人： GE, Jian ,  WANG, Yandong ,  LIU, Yizhi ,  WU, Lingyun ,  YOU, Xu ,  XIAO, Zheming ,  CHEN, Shuhui

IPC分类号： C07D401/12 ,  A61P27/06 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61K31/551 ,  A61P9/08

摘要： Disclosed is a salt form of an isoquinolinone type compound as a ROCK protein kinase inhibitor and a preparation method therefor, and use of the salt form in the preparation of a medicament for treating glaucoma or ocular hypertension is further included.

公开(公告)号：EP3988544A1

公开(公告)日：2022-04-27

申请号：EP20827811.9

申请日：2020-06-22

申请人： Guangzhou Ocusun Ophthalmic Biotechnology Co., Ltd.

发明人： LIU, Yizhi ,  WANG, Yandong ,  WU, Lingyun ,  YOU, Xu ,  XIAO, Zheming ,  CHEN, Shuhui

IPC分类号： C07D401/12 ,  C07D401/14 ,  A61K31/551 ,  A61P7/02 ,  A61P9/10 ,  A61P9/08 ,  A61P27/06 ,  A61P9/12

摘要： Disclosed are a series of isoquinolone derivatives as ROCK protein kinase inhibitors and uses thereof in preparing medicaments for ROCK protein kinase inhibitor-related glaucoma or ocular hypertension diseases. Specially, disclosed are a compound of formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.