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    Homocarnosine or acylhomocarnosine salts
    2.
    发明公开
    Homocarnosine or acylhomocarnosine salts 失效
    同种异黄酮酸酰基卡诺昔康盐

    公开(公告)号：EP0192317A1

    公开(公告)日：1986-08-27

    申请号：EP86300076.6

    申请日：1986-01-07

    申请人： HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD.

    发明人： Takaya, Masahiro

    IPC分类号： C07D233/64 ,  A61K31/415

    CPC分类号： C07D233/64

    摘要： Homocarnosine or acylhomocarnosine aluminum and zinc salts of the formula:
    wherein R represents a hydrogen atom or an acyl group; M represents a zinc atom or an aluminum atom; a denotes 1, 2 or 3; and b denotes 0,1 or 2, provided that when a denotes 1, b denotes 0 and M represents zinc, a hydrogen atom is omitted from the homocarnosine or acylhomocarnosine residue, have antiulcer and wound healing-promoting activities and very low toxicity.

    摘要翻译： 同型半胱氨酸或酰基焦马来诺铝和下式的锌盐：其中R表示氢原子或酰基; M表示锌原子或铝原子; a表示1,2或3; 并且b表示0,1或2，条件是当a表示1时，b表示0且M表示锌，从高卡诺胶或酰基卡马诺糖残基中省略氢原子，具有抗溃疡和伤口愈合促进活性，毒性非常低。

    Crystalline L-carnosine zinc complex and production thereof
    6.
    发明公开
    Crystalline L-carnosine zinc complex and production thereof 失效
    Kristalliner L-Carnosin-Zink-Komplex und dessen Herstellung。

    公开(公告)号：EP0303380A2

    公开(公告)日：1989-02-15

    申请号：EP88307090.6

    申请日：1988-08-01

    申请人： HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD.

    发明人： Matsukura, Takefumi ,  Takahashi, Tamiko ,  Nishimura, Yasuhiro ,  Takaya, Masahiro ,  Fujimura, Hajime

    IPC分类号： C07K5/06 ,  C07K1/02 ,  A61K37/02

    CPC分类号： C07D233/64 ,  C07F3/003

    摘要： A novel crystalline L-carnosine zinc complex is produced by reacting L-carnosine, a zinc salt and an alkali metal compound in an anhydrous or hydrous polar organic sol­vent.
    The crystalline L-carnosine zinc complex substantially corresponds to the formula C₉H₁₂N₄O₃Zn and has physi­cal properties clearly different from the known amorphous L-carnosine zinc complex.
    As compared with the amorphous complex, the crystal­line complex is very low in impurity, stable to heat and moisture, and easy to filtrate, and has higher anti­ulcer activity.

    摘要翻译： 通过在无水或含水极性有机溶剂中使L-肌肽，锌盐和碱金属化合物反应，生成新的结晶L-肌肽锌络合物。 结晶L-肌肽锌络合物基本上对应于式C9H12N4O3Zn，并且具有与已知的无定形L-肌肽锌复合物明显不同的物理性质。 与无定形复合物相比，结晶复合物杂质非常低，对热和水分稳定，易于滤液，抗溃疡活性更高。

    1,5-Benzothiazepine derivatives and production thereof
    7.
    发明公开
    1,5-Benzothiazepine derivatives and production thereof 失效
    1,5-Benzothiazepin-Derivate und Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0137083A1

    公开(公告)日：1985-04-17

    申请号：EP83306147.6

    申请日：1983-10-11

    申请人： HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD.

    发明人： Maki, Yoshifumi ,  Sako, Magoichi ,  Mitsumori, Naomichi ,  Maeda, Sadayuki ,  Takaya, Masahiro

    IPC分类号： C07D281/10 ,  A61K31/55

    CPC分类号： C07D277/68 ,  C07D279/16 ,  C07D281/10

    摘要： Novel 1,5-benzothiazepine derivatives having the formula:
    wherein R,, R 2 and R 3 each denotes hydrogen, a halogen, a lower alkyl group, a lower alkoxy group or a hydroxy group; R 4 denotes a lower alkyl group, an allyl group, a lower alkoxyalkyl group, a lower alkyl group substituted with a hydroxy group or a halogen, a lower alkylaminoalkyl group or a morpholino lower alkyl group; X denotes a halogen or hydrogen, are produced from corresponding 1,4-benzothiazine by a ring expansion reaction with trimethylhalosilane, hydrogen peroxide and water. The derivatives have analgesic, antipyretic and antiarrhythmic activities.

    摘要翻译： 具有下式的新的1,5-苯并硫氮杂衍生物：其中R 1，R 2和R 3各自表示氢，卤素，低级烷基，低级烷氧基或羟基; R4表示低级烷基，烯丙基，低级烷氧基烷基，被羟基或卤素取代的低级烷基，低级烷基氨基烷基或吗啉代低级烷基。 X表示卤素或氢，通过与三甲基卤硅烷，过氧化氢和水的环膨胀反应由相应的1,4-苯并噻嗪制备。 衍生物具有镇痛，解热和抗心律失常作用。