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公开(公告)号：EP0322198B1
公开(公告)日：1994-05-18
申请号：EP88312075.0
申请日：1988-12-20
IPC分类号： C07D487/22 , A61K31/40 , A61K49/00
CPC分类号： C07D487/22 , A61K41/0071
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2.发明公开N epsilon-trifluoroacetyl-L-lysyl-L-proline.D-1O-camphorsulfonic acid salt and process for producing the same 失效Nε-三氟乙酰-L-赖氨酰-L-脯氨酸D-10-樟脑磺酸盐及其制备方法
公开(公告)号：EP0293244A3
公开(公告)日：1990-05-30
申请号：EP88304859.7
申请日：1988-05-27
IPC分类号： C07K5/06
CPC分类号： C07K5/06086 , A61K38/00 , C07K5/06191
摘要： N ε -Trifluoroacetyl-L-lysyl-L-proline·D-10-camphorsulfonic acid salt is produced in very high purity by reacting Ne-trifluoroacetyl-L-lysyl-L-proline with D-10-camphorsulfonic acid in a suitable solvent. The salt is extremely stable at ambient temperature as compared with other salts of N ε -trifluoroacetyl-L-lysyl-L-proline including the known dicyclohexylamine salt.
摘要翻译： 通过使Ne-三氟乙酰基-L-赖氨酰-L-脯氨酸与D-10-樟脑磺酸在合适的溶剂中反应，以非常高的纯度产生Nε-三氟乙酰基-L-赖氨酰基-L-脯氨酸·D-10-樟脑磺酸盐。 与包括已知二环己基胺盐的Nε-三氟乙酰基-L-赖氨酰-L-脯氨酸的其他盐相比，盐在环境温度下非常稳定。
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公开(公告)号：EP0192317B1
公开(公告)日：1990-02-28
申请号：EP86300076.6
申请日：1986-01-07
发明人： Takaya, Masahiro
IPC分类号： C07D233/64 , A61K31/415
CPC分类号： C07D233/64
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公开(公告)号：EP0322198A3
公开(公告)日：1989-12-20
申请号：EP88312075.0
申请日：1988-12-20
IPC分类号： C07D487/22 , A61K31/40 , A61K49/00
CPC分类号： C07D487/22 , A61K41/0071
摘要： Novel pheophoribide derivative of the general formula:
(wherein Z is O or NH; n is an integer of 1 to 6; Y is NR′R˝ or
(wherein R′, R˝ and R‴ are the same or different and each represents a C₁ to C₄ lower alkyl group; and X⁻ is a halogen or organic acid ion); R₁ is an ethenyl group, C₁ to C₄ lower alkyl group or
(wherein m is an integer of 0 to 6, R₆ is H or a C₁ to C₄ lower alkyl group); R₂ is CH₃, CHO or CH₂OH; either of R₃ and R₄ is H, with the other being OH, or both of them combine to represent =O; R₅ is H or CO₂CH₃) are useful in photodynamic diagnosis and therapy of cancer tissues.-
公开(公告)号：EP0192317A1
公开(公告)日：1986-08-27
申请号：EP86300076.6
申请日：1986-01-07
发明人： Takaya, Masahiro
IPC分类号： C07D233/64 , A61K31/415
CPC分类号： C07D233/64
摘要： Homocarnosine or acylhomocarnosine aluminum and zinc salts of the formula:
wherein R represents a hydrogen atom or an acyl group; M represents a zinc atom or an aluminum atom; a denotes 1, 2 or 3; and b denotes 0,1 or 2, provided that when a denotes 1, b denotes 0 and M represents zinc, a hydrogen atom is omitted from the homocarnosine or acylhomocarnosine residue, have antiulcer and wound healing-promoting activities and very low toxicity.摘要翻译： 同型半胱氨酸或酰基焦马来诺铝和下式的锌盐：其中R表示氢原子或酰基; M表示锌原子或铝原子; a表示1,2或3; 并且b表示0,1或2，条件是当a表示1时，b表示0且M表示锌，从高卡诺胶或酰基卡马诺糖残基中省略氢原子，具有抗溃疡和伤口愈合促进活性，毒性非常低。
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公开(公告)号：EP0121444A3
公开(公告)日：1986-08-13
申请号：EP84302316
申请日：1984-04-04
CPC分类号： C12P13/007
摘要： L-carntine is produced by bringing apocarnitine into contact with hydrase produced by a strain of Enterobacter in an aqueous medium having a pH of 4-10 at a temperature of 20-60°C, thereby apocarnintine is converted to L-carnitine.
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公开(公告)号：EP0356152B1
公开(公告)日：1993-02-10
申请号：EP89308369.1
申请日：1989-08-17
发明人： Mitsumori, Naomichi , Nishimura, Yasuhiro , Yokota, Keiko 201, Gurinhaitsu-Hirabari , Okuno, Shiro , Suzuki, Motoko
IPC分类号： C07C237/02 , C07D453/02 , C07D295/15 , C07D213/04 , C07D213/75 , C07D213/82 , C07D295/135 , A61K31/165 , A61K31/435 , A61K31/535
CPC分类号： C07D213/20 , C07C237/04 , C07D295/15
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公开(公告)号：EP0303380A3
公开(公告)日：1990-01-31
申请号：EP88307090.6
申请日：1988-08-01
发明人： Matsukura, Takefumi , Takahashi, Tamiko , Nishimura, Yasuhiro , Takaya, Masahiro , Fujimura, Hajime
CPC分类号： C07D233/64 , C07F3/003
摘要： A novel crystalline L-carnosine zinc complex is produced by reacting L-carnosine, a zinc salt and an alkali metal compound in an anhydrous or hydrous polar organic solvent. The crystalline L-carnosine zinc complex substantially corresponds to the formula C₉H₁₂N₄O₃Zn and has physical properties clearly different from the known amorphous L-carnosine zinc complex. As compared with the amorphous complex, the crystalline complex is very low in impurity, stable to heat and moisture, and easy to filtrate, and has higher antiulcer activity.
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公开(公告)号：EP0335539A2
公开(公告)日：1989-10-04
申请号：EP89302670.8
申请日：1989-03-17
IPC分类号： C07D487/22 , A61K31/40
CPC分类号： C07D487/22
摘要： Porphyrin derivatives of the formula A:
wherein each R₁ independently is a hydrogen atom, a C₁-C₄ alkyl group, an ethenyl group, or a 2-hydroxyethyl group; one R₂ is a hydroxyl group and the other R₂ is
(each A, B, and C is independently a C₁-C₄ alkyl group; X⁻ is an halogen or organic acid ion; and m is an integer of 1 to 23, and pharmaceutically acceptable salts are photosensitive, less accumulable in the skin and specifically accumulative in cancer tissues as compared with known porphyrins. They can be obtained from the corresponding diester compounds.摘要翻译： 式A的卟啉衍生物：
其中每个R 1独立地是氢原子，C 1 -C 4烷基，乙烯基或2-羟基乙基; 一个R2是羟基，另一个R2是 （每个A，B和C独立地是C1-C4烷基; X是卤素或有机酸离子; m是整数1 和其药学上可接受的盐是光敏的，在已知的卟啉中与皮肤相比较少积累，特别是在癌组织中累积，它们可以从相应的二酯化合物中获得。 -
公开(公告)号：EP0322198A2
公开(公告)日：1989-06-28
申请号：EP88312075.0
申请日：1988-12-20
IPC分类号： C07D487/22 , A61K31/40 , A61K49/00
CPC分类号： C07D487/22 , A61K41/0071
摘要： Novel pheophoribide derivative of the general formula:
(wherein Z is O or NH; n is an integer of 1 to 6; Y is NR′R˝ or
(wherein R′, R˝ and R‴ are the same or different and each represents a C₁ to C₄ lower alkyl group; and X⁻ is a halogen or organic acid ion); R₁ is an ethenyl group, C₁ to C₄ lower alkyl group or
(wherein m is an integer of 0 to 6, R₆ is H or a C₁ to C₄ lower alkyl group); R₂ is CH₃, CHO or CH₂OH; either of R₃ and R₄ is H, with the other being OH, or both of them combine to represent =O; R₅ is H or CO₂CH₃) are useful in photodynamic diagnosis and therapy of cancer tissues.摘要翻译： 具有以下通式的新型酚硫代磷酸酯衍生物：（其中Z是O或NH; n是1至6的整数; Y是NR'R 6或（其中R'，R 7和R 8相同或不同，并且各自表示 C 1 -C 4低级烷基; X - 是卤素或有机酸根离子）; R 1是乙烯基，C 1 -C 4低级烷基或（其中m是0-6的整数，R 6是H或C 1 至C 4低级烷基）; R 2是CH 3，CHO或CH 2 OH; R 3和R 4中任何一个是H，另一个是OH，或二者合在一起代表= O; R 5是H或CO 2 CH 3） 和癌症组织的治疗。
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