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    PROCESS FOR PREPARING EXTRA PURE 2, 6-DIISOPROPYL PHENOL
    4.
    发明公开
    PROCESS FOR PREPARING EXTRA PURE 2, 6-DIISOPROPYL PHENOL 有权
    用于生产超纯2,6-二异丙基

    公开(公告)号：EP2516369A4

    公开(公告)日：2013-05-29

    申请号：EP10853576

    申请日：2010-08-10

    申请人： HARMAN FINOCHEM LTD

    发明人： JAIN KIRTI PRAKASH ,  EDAKI DHANANJAY UDDHAVRAO ,  MINHAS HARPREET SINGH ,  MINHAS GURPREET SINGH

    IPC分类号： C07C39/06 ,  A61K31/05 ,  A61P23/00

    CPC分类号： C07C37/11 ,  A61K31/05 ,  C07C37/50 ,  C07C51/353 ,  C07C51/48 ,  C07C39/06 ,  C07C63/04

    摘要： Disclosed herein is a process for the preparation of highly pure 2,6-diisopropyl phenol (Formula I), which comprises reacting p-hydroxy benzoic acid (Formula II) with an alkylating agent in presence of aq. mineral acid followed by basification and subsequent washings to yield 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) free of dimer impurity, 4,4'-oxydibenzoic acid of Formula IV, ether impurity 3,5-di(propan-2-yl)-4-(propan-2-yloxy)benzoic acid of Formula V and the monoalkylated impurity 4-hydroxy-3-(propan-2-yl)benzoic acid of Formula VI; and decarboxylating 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) in presence of high boiling solvent and sodium hydroxide as a catalyst at high temperature to yield 2,6-diisopropyl phenol substantially free of ether impurity 1,3-di(propan-2-yl)-2-(propan-2-yloxy)benzene of Formula VII and monoalkylated phenol impurity 2-(propan-2-yl) phenol of Formula VIII. Propofol prepared by the process of the present invention is suitable for pharmaceutical use.