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公开(公告)号：EP3364957A1
公开(公告)日：2018-08-29
申请号：EP16858366.4
申请日：2016-10-21
CPC分类号： C07C37/0555 , C07C37/11 , C07C37/14 , C07C37/50 , C07C39/15 , C07C39/21 , C07C41/09 , C07C41/16 , C07C41/22 , C07C41/24 , C07C41/30 , C07C43/2055 , C07C43/225 , C07C43/215
摘要： Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol, 3′,5-dimethyl-[1,1′-biphenyl]-2,4′-diol, and 2,4′-dimethoxy-3′,5-dimethyl-1,1′-biphenyl, 3,3′,5,5′-tetra-tert-butyl-[1,1′-biphenyl]-2,4′-diol, and certain tetrasubstituted bisphenols, and uses therefor.
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公开(公告)号：EP2949638A1
公开(公告)日：2015-12-02
申请号：EP15168685.4
申请日：2015-05-21
申请人： Evonik Degussa GmbH
发明人： Dyballa, Katrin Marie , Franke, Robert , Fridag, Dirk , Waldvogel, Siegfried R. , Quell, Thomas , Mirion, Michael
摘要： Verfahren zur Herstellung von 2,2'-Biphenolen unter Verwendung von Selendioxid.
摘要翻译： 制备2,2'-联苯酚的方法是由a）向反应混合物中加入第一酚，b）向反应混合物中加入第二酚，c）向反应混合物中加入二氧化硒，d） 对反应混合物具有0.0-5.0的pKa的酸，以及e）加热反应混合物使得第一酚和第二酚转化成所述的2,2'-联苯酚。
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公开(公告)号：EP2516369A4
公开(公告)日：2013-05-29
申请号：EP10853576
申请日：2010-08-10
申请人： HARMAN FINOCHEM LTD
摘要： Disclosed herein is a process for the preparation of highly pure 2,6-diisopropyl phenol (Formula I), which comprises reacting p-hydroxy benzoic acid (Formula II) with an alkylating agent in presence of aq. mineral acid followed by basification and subsequent washings to yield 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) free of dimer impurity, 4,4'-oxydibenzoic acid of Formula IV, ether impurity 3,5-di(propan-2-yl)-4-(propan-2-yloxy)benzoic acid of Formula V and the monoalkylated impurity 4-hydroxy-3-(propan-2-yl)benzoic acid of Formula VI; and decarboxylating 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) in presence of high boiling solvent and sodium hydroxide as a catalyst at high temperature to yield 2,6-diisopropyl phenol substantially free of ether impurity 1,3-di(propan-2-yl)-2-(propan-2-yloxy)benzene of Formula VII and monoalkylated phenol impurity 2-(propan-2-yl) phenol of Formula VIII. Propofol prepared by the process of the present invention is suitable for pharmaceutical use.
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4.发明公开3-Alkylated-5,5',6,6',7,7',8,8'-Octahydro-2,2'-Binaphthols and 3,3'-Dialkylated-5,5',6,6',7,7',8,8'-Octahydro-2,2'-Binaphthols and processes for making them 审中-公开3-烷基化的5,5'，6,6'，7,7'，8,8'-八氢-2,2'-联萘酚和3,3'-二烷基化的-5,5'，6,6' 7,7'，8,8'-八氢-2,2'-联萘酚及其制备方法
公开(公告)号：EP2279994A1
公开(公告)日：2011-02-02
申请号：EP10179062.4
申请日：2002-11-20
发明人： Lu, Helen S.M. , Qiu, Weiming , Shapiro, Rafael
CPC分类号： C07C39/17 , C07C37/11 , C07C37/14 , C07C37/16 , C07C37/18 , C07C2601/10 , C07C2602/10
摘要： The composition 3-alkylated-5,5',6,6',7,7',8,8'-octahydro-2,2'-binaphthols and 3,3'-dialkylated- 5,5',6,6',7,7',8,8'-octahydro-2,2'-binaphthols are disclosed, as well as various processes for making them, all involving the alkylation of 5,5',6,6',7,7',8,8'-octahydro-2,2'-binaphthol.
摘要翻译： 组合物3-烷基化-5,5'，6,6'，7,7'，8,8'-八氢-2,2'-联萘酚和3,3'-二烷基化-5,5'，6,6 '，7,7'，8,8'-八氢-2,2'-联萘酚及其制备方法，包括5,5'，6,6'，7,7 ”，8,8'-八氢-2,2'-联萘酚。
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5.发明公开PROCESS FOR PRODUCING TRIPHENYLENE COMPOUND AND CRYSTAL OBTAINED BY THE PROCESS 审中-公开Verfahren zur Herstellung von Hexahydroxytriphenylen-Derivaten
公开(公告)号：EP2177495A1
公开(公告)日：2010-04-21
申请号：EP08792270.4
申请日：2008-08-06
CPC分类号： C07C39/12 , C07B2200/13 , C07C37/11 , C07C37/84 , C07C2603/42 , Y02P20/55
摘要： An object of the present invention is to provide a process for producing high-purity hydroxytriphenylenes in which not only inexpensive raw materials can be used but also no complicated steps of deprotection such as dealkylation, and reduction and the like are necessary, and which is thereby advantageous in industrial production. Also there is provided a novel crystal of 2,3,6,7,10,11-hexahydroxytriphenylene monohydrate, which has satisfactory thermal stability. The process for producing a compound represented by the general formula (2) is characterized by reacting a compound represented by the general formula (1) in the presence of a metal oxide comprising a metal selected from trivalent iron, pentavalent vanadium and hexavalent molybdenum and of a nonvolatile strong acid:
wherein, Rs are each independently a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms or an alkoxy group having 1 to 3 carbon atoms.摘要翻译： 本发明的目的是提供一种制备高纯度羟基三苯基的方法，其中不仅可以使用廉价的原料，而且不需要复杂的脱保护步骤如脱烷基化和还原等，从而 有利于工业生产。 还提供了具有令人满意的热稳定性的2,3,6,7,10,11-六羟基三亚苯一水合物的新晶体。 由通式（2）表示的化合物的制备方法的特征在于使通式（1）表示的化合物在包含选自三价铁，五价钒和六价钼的金属的金属氧化物存在下反应， 非挥发性强酸：其中，R 5各自独立地为氢原子，卤素原子，碳原子数为1〜3的烷基或碳原子数为1〜3的烷氧基。
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公开(公告)号：EP1676826A4
公开(公告)日：2007-08-29
申请号：EP04792981
申请日：2004-10-20
发明人： KAMESHIMA TAKASHI
CPC分类号： C07C37/11 , C07C2603/42 , C07C39/12
摘要： The present invention provides a simple and efficient method for producing high-purity 2,3,6,7,10,11-hexahydroxytriphenylene on an industrial scale. The method for producing 2,3,6,7,10,11-hexahydroxytriphenylene comprises reacting catechol with peroxide.
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7.发明授权POLYMERIC, PHOSPHOROUS-CONTAINING COMPOSITIONS AND THEIR USE IN HYDROCYANATION, ISOMERIZATION AND HYDROFORMYLATION REACTIONS 有权聚合物含磷化合物及它们在氢氰化，异构化和加氢甲酰化反应
公开(公告)号：EP1448668B1
公开(公告)日：2006-08-09
申请号：EP02789715.6
申请日：2002-11-18
发明人： RADU, Nora, S. , TAM, Wilson
IPC分类号： C08G65/48 , C08G63/692 , B01J31/18 , B01J31/16
CPC分类号： C08G65/485 , B01J31/1658 , B01J31/1845 , B01J31/185 , B01J31/1865 , B01J31/1875 , B01J2231/321 , B01J2231/323 , B01J2231/52 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/845 , B01J2531/847 , C07C37/11 , C07C37/14 , C07C45/50 , C07C253/10 , C07C253/30 , C08G79/02 , C08L85/02 , C07C255/04 , C07C255/07 , C07C39/06 , C07C39/15 , C07C47/02
摘要： A polymeric, phosphorus-containing composition derived from aryl to aryl coupling of a substituted 2,2'-dihydroxyl-1,1'-binaphthalene or a substituted 2,2'-dihydroxyl-1,1'-biphenylene and phosphonylated at the dioxyl of said structure with at least one diaryloxyphosphite [-P(-O-Ar)2], diarylphosphine [-P(Ar)2] and/or aryl,aryloxyphosphinite [-P(Ar)(-O-Ar)], where each Ar is individually phenyl, substituted phenyl, naphthyl, and substituted naphthyl, provided that the two Ar groups that are directly or indirectly bonded to the same phosphorus atom may be linked to each other by a linking unit selected from direct bond, alkylidene, secondary or tertiary amine, oxygen, sulfide, sulfone, and sulfoxide. Polymerization by aryl to aryl coupling is achieved by direct oxidative coupling of the binaphthalene or biphenylene, copolymerization with an aromatic comonomer, or copolymerization with an aldehyde. The phosphonylation may be performed prior to or after polymerization. The polymeric, phosphorus-containing compositions in combination with a Group VIII metal and, optionally a Lewis acid, are particularly useful in the catalytic hydrocyanation of unsaturated organic compounds, isomerization of unsaturated, branched nitriles to unsaturated linear nitriles, and hydroformylation of unsaturated organic compounds.
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8.发明公开PROCESS FOR PREPARATION OF 3,5-BISALKYLPHENOLS 有权VERFAHREN ZUR HERSTELLUNG VON 3,5-BISALKYLPHENOLEN
公开(公告)号：EP1319646A4
公开(公告)日：2005-11-30
申请号：EP01970181
申请日：2001-09-21
申请人： KOWA CO
发明人： SHIBUYA KIMIYUKI , OHGIYA TADAAKI , MIURA TORU , ONOGI KAZUHIRO
IPC分类号： C07C37/01 , C07C37/00 , C07C37/11 , C07C37/50 , C07C39/06 , C07C39/11 , C07C39/235 , C07C43/23 , C07C37/82 , C07C41/26 , C07C41/36
CPC分类号： C07C41/30 , C07C37/002 , C07C37/11 , C07C37/50 , C07C39/11 , C07C43/23 , Y02P20/55 , C07C39/06
摘要： A process for preparing 3,5-bisalkylphenols (2) from carbinol compounds (1); carbinol compounds (1); and a process for preparation of the compounds (1): (1) (2) [wherein R is hydrogen, alkali metal, alkaline earth metal, or a hydroxyl-protecting group(except methyl); R is C1-5 lower alkyl or optionally substituted phenyl; and R and R are each independently lower alkyl, aralkyl, or aryl]. This invention enables efficient and safe preparation of various 3,5-bisalkylphenols including 3,5-diisopropylphenol (which is important as an intermediate in the synthesis of drugs and agricultural chemicals) in shorter steps at high purity in high yield, thus contributing to stable supply of the drugs and agricultural chemicals.
摘要翻译： 从甲醇化合物（1）制备3,5-双烷基酚（2）的方法; 甲醇化合物（1）; （1）的制备方法：（1）（2）[其中R 1为氢，碱金属，碱土金属或羟基保护基（除甲基以外）; R 2是C 1-5低级烷基或任选取代的苯基; 并且R 3和R 4各自独立地为低级烷基，芳烷基或芳基]。 本发明能够以高收率以高纯度以较短步骤高效且安全地制备各种3,5-二烷基酚，包括3,5-二异丙基苯酚（其作为药物和农用化学品合成中的重要中间体），因此有助于稳定 药品和农药的供应。
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9.发明公开3-ALKYLATED-5,5',6,6',7,7',8,8'-OCTAHYDRO-2,2'-BINAPHTHOLS AND 3,3'-DIALKYLATED-5,5',6,6',7,7',8,8'-OCTAHYDRO-2,2'-BINAPHTHOLS AND PROCESSES FOR MAKING THEM 有权3-烷基-5,5'，6,6'，7,7'，8,8'-二羟基-2,2'-二萘酚和3,3'-二烷基化的-5,5'，6,6' 7,7'，8,8'-OCTAHYDRO-2,2'-联萘及其制备方法
公开(公告)号：EP1465851A1
公开(公告)日：2004-10-13
申请号：EP02789788.3
申请日：2002-11-20
发明人： LU, Helen, S.M. , QIU, Weiming , SHAPIRO, Rafael
CPC分类号： C07C39/17 , C07C37/11 , C07C37/14 , C07C37/16 , C07C37/18 , C07C2601/10 , C07C2602/10
摘要： The compositions 3-alkylated-5,5',6,6',7,7',8,8'-octahydro-2,2'-binaphthol and 3,3'-dialkylated-5,5',6,6',7,7',8,8'-octahydro-2,2'-binaphthol are disclosed, as well as various processes for making them, all involving the alkylation of 5,5',6,6',7,7',8,8'-octahydro-2,2'-binaphthol.
摘要翻译： 组合物3-烷基化-5,5'，6,6'，7,7'，8,8'-八氢-2,2'-联萘酚和3,3'-二烷基化-5,5'，6,6 '，7,7'，8,8'-八氢-2,2'-联萘酚及其制备方法，包括5,5'，6,6'，7,7 ”，8,8'-八氢-2,2'-联萘酚。
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公开(公告)号：EP1112993B1
公开(公告)日：2004-07-28
申请号：EP01104793.3
申请日：1998-01-29
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