专利检索 ap:("HARVARD COLLEGE" OR "BRIGHAM & WOMENS HOSPITAL" OR "UNIV BOSTON" OR "UNIV TUFTS") AND inv:"TENG XIN" 第 1 页

1.

发明公开
HETEROCYCLIC INHIBITORS OF NECROPTOSIS 审中-公开
标题翻译：杂环抑制剂性坏死

公开(公告)号：EP2192838A4

公开(公告)日：2011-07-27

申请号：EP08795375

申请日：2008-08-15

申请人： HARVARD COLLEGE , BRIGHAM & WOMENS HOSPITAL , UNIV BOSTON , UNIV TUFTS

发明人： CUNY GREGORY D , TENG XIN , YUAN JUNYING , DEGTEREV ALEXEI , PORCO JOHN A JR

IPC分类号： A01N43/82 , A61K31/41

CPC分类号： C07D417/12 , C07D207/34 , C07D231/14 , C07D241/24 , C07D263/34 , C07D277/56 , C07D285/06 , C07D307/68 , C07D307/84 , C07D333/38

摘要： The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-±) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-± induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.