专利检索 ap:("HARVARD COLLEGE" OR "THE CHILDREN'S MEDICAL CENTER CORP") AND inv:"COWAN CHAD A" 第 1 页

1.

发明公开
THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/CAS SYSTEMS 审中-公开
标题翻译：护肤品维生素EINERGENOMÄNDERUNGMIT CRISPR- / CAS-SYSTEMEN

公开(公告)号：EP2981617A4

公开(公告)日：2017-01-11

申请号：EP14779492

申请日：2014-04-04

申请人： HARVARD COLLEGE , THE CHILDREN'S MEDICAL CENTER CORP

发明人： MUSUNURU KIRAN , COWAN CHAD A , ROSSI DERRICK J

IPC分类号： C12N15/87 , C12N15/00 , C12N15/11

CPC分类号： C12N15/63 , A61K48/00 , C12N15/907

2.

发明公开
UNIVERSAL DONOR STEM CELLS AND RELATED METHODS 审中-公开

公开(公告)号：EP3294342A2

公开(公告)日：2018-03-21

申请号：EP16793348

申请日：2016-05-09

申请人： HARVARD COLLEGE

发明人： MEISSNER TORSTEN B , FERREIRA LEONARDO M R , STROMINGER JACK L , COWAN CHAD A

IPC分类号： A61K48/00 , C07K14/74 , C12N5/0735

CPC分类号： A61K39/001 , C12N5/0606 , C12N5/0696 , C12N2501/50 , C12N2501/599 , C12N2501/998 , C12N2510/00

摘要： Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.