公开(公告)号：EP2702044A4

公开(公告)日：2014-06-04

申请号：EP12777741

申请日：2012-02-16

申请人： HETERO RESEARCH FOUNDATION

发明人： PARTHASARADHI REDDY BANDI ,  RATHNAKAR REDDY KURA ,  MURALIDHARA REDDY DASARI ,  VENKAT NARSIMHA REDDY ADULLA ,  VAMSI KRISHNA BANDI

IPC分类号： C07D239/42

CPC分类号： C07D239/48 ,  A61K31/505 ,  C07C209/74 ,  C07D239/42

公开(公告)号：EP2872492A4

公开(公告)日：2016-01-13

申请号：EP13816744

申请日：2013-07-08

申请人： HETERO RESEARCH FOUNDATION ,  PARTHASARADHI REDDY BANDI ,  RATHNAKAR REDDY KURA ,  MURALIDHARA REDDY DASARI ,  VENKAT NARSIMHA REDDY ADULLA ,  VAMSI KRISHNA BANDI

发明人： PARTHASARADHI REDDY BANDI ,  RATHNAKAR REDDY KURA ,  MURALIDHARA REDDY DASARI ,  VENKAT NARSIMHA REDDY ADULLA ,  VAMSI KRISHNA BANDI

IPC分类号： C07D239/42 ,  C07D239/48

CPC分类号： C07D239/48 ,  C07D239/42

摘要： The present invention provides a commercially viable process for preparing rilpivirine and its pharmaceutically acceptable acid addition salts thereof in high yields using novel intermediate.

公开(公告)号：EP2755959A4

公开(公告)日：2015-08-26

申请号：EP12831918

申请日：2012-09-10

申请人： HETERO RESEARCH FOUNDATION

发明人： PARTHASARADHI REDDY BANDI ,  RATHNAKAR REDDY KURA ,  MURALIDHARA REDDY DASARI ,  VENKAT NARSIMHA REDDY ADULLA ,  VAMSI KRISHNA BANDI

IPC分类号： C07D239/48

CPC分类号： C07D239/48 ,  A61K31/505

摘要： The present invention provides a novel process for the preparation of rilpivirine. The present invention also provides a novel process for the preparation of rilpivirine hydrochloride. The present invention further provides a rilpivirine hydrochloride monohydrate, process for its preparation and pharmaceutical compositions comprising it.

摘要翻译： 本发明提供了一种制备利比利林的新方法。 本发明还提供了一种制备盐酸利比利林的新方法。 本发明还提供了一种盐酸利乐维林一水合物，其制备方法和包含它的药物组合物。

公开(公告)号：EP2584901A4

公开(公告)日：2013-10-09

申请号：EP10854026

申请日：2010-06-28

申请人： HETERO RESEARCH FOUNDATION

发明人： PARTHASARADHI REDDY BANDI ,  RATHNAKAR REDDY KURA ,  MURALIDHARA REDDY DASARI ,  RAJI REDDY RAPOLU ,  VAMSI KRISHNA BANDI ,  VENKAT NARSIMHA REDDY ADULLA

IPC分类号： A01N43/54 ,  A61K31/505

CPC分类号： C07D239/47 ,  A61K31/505

摘要： 4-[[6-chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-benzonitrile is a key intermediate for the preparation of etravirine. The present invention provides a process for preparation of 4-[[6-chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile. The present invention also provides a novel process for the preparation of etravirine crystalline form I. The present invention further provides novel crystalline forms of etravirine, processes for their preparation and pharmaceutical compositions comprising them.

摘要翻译： 4 - [[6-氯-2 - [（4-氰基苯基）氨基] -4-嘧啶基]氧基] -3,5-二甲基 - 苯甲腈是制备依曲韦林的关键中间体。 本发明提供了制备4 - [[6-氯-2 - [（4-氰基苯基）氨基] -4-嘧啶基]氧基] -3,5-二甲基苄腈的方法。 本发明还提供了制备依曲韦林结晶形式I的新方法。本发明进一步提供了依曲韦林的新结晶形式，它们的制备方法和包含它们的药物组合物。