APOVINCAMINIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME
    1.
    发明公开
    APOVINCAMINIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME 失效
    Apovincaminic衍生物及药物含有它们的

    公开(公告)号:EP0864571A4

    公开(公告)日:1998-12-02

    申请号:EP95938607

    申请日:1995-11-29

    申请人: HIDAKA HIROYOSHI

    IPC分类号: C07D461/00 A61K31/435

    CPC分类号: C07D461/00

    摘要: An apovincaminic acid derivative represented by general formula (I) or an acid-addition salt thereof and a medicine containing the same (wherein R1 represents lower alkyl; and R2 represents aryl optionally substituted by 1 to 5 substituents selected from among halogeno, lower alkyl, lower alkoxy, lower alkoxycarbonyl, acylamino and nitro, benzyl, quinolyl or thienyl), having excellent vasodilator and platelet aggregation inhibitory effects, and being usable in treating cerebrovascular disorders, thrombus formation/embolization and chronic arterial obliteration and ameliorating blood flow disorders.

    METHOD FOR IN VIVO DETECTING A TARGET PROTEIN GENE BY A DRUG
    3.
    发明公开
    METHOD FOR IN VIVO DETECTING A TARGET PROTEIN GENE BY A DRUG 失效
    PROCEDURE用于确定所述基因中的靶蛋白的使用的药物

    公开(公告)号:EP1072688A4

    公开(公告)日:2002-05-22

    申请号:EP98914021

    申请日:1998-04-15

    申请人: HIDAKA HIROYOSHI

    CPC分类号: C12N15/1048

    摘要: A method for in vivo detecting a target protein gene by a drug, which comprises binding an antigenic substance to a drug to be administered to a living organism via a chemical crosslinker, using the obtained material as a probe, and directly screening the gene of the protein bonded to the above probe by using a cDNA expression library containing genes of the living organism to which the drug is to be administered. Compared with the conventional drug-fixed column methods, the above method makes it possible to directly and conveniently isolate the gene of the target molecule without resort to the purification of the protein and the analysis of the amino acid sequence thereof.