摘要:
An apovincaminic acid derivative represented by general formula (I) or an acid-addition salt thereof and a medicine containing the same (wherein R1 represents lower alkyl; and R2 represents aryl optionally substituted by 1 to 5 substituents selected from among halogeno, lower alkyl, lower alkoxy, lower alkoxycarbonyl, acylamino and nitro, benzyl, quinolyl or thienyl), having excellent vasodilator and platelet aggregation inhibitory effects, and being usable in treating cerebrovascular disorders, thrombus formation/embolization and chronic arterial obliteration and ameliorating blood flow disorders.
摘要:
An aminostilbazole derivative represented by general formula (I) or a hydrate and a salt thereof, useful for treating various types of malignant tumor. In said formula R?1 and R2¿ represent each hydrogen, etc.; R?3, R4, R13 and R14¿ represent each hydrogen, C¿1?-C3 acyl, halogen, hydroxy, etc.; R?5¿ represents hydrogen, hydroxylated C¿1?-C3 alkyl, etc.; R?6¿ represents C¿1?-C3-alkoxy-substituted benzenesulfonyl, etc.; ring Y represents phenyl, etc.; and ring Z represents 4-pyridyl, and oxide thereof, etc.
摘要翻译:由通式(I)表示的氨基芪衍生物或其水合物和盐,可用于治疗各种类型的恶性肿瘤。 在所述式中,R 1和R 2'各自代表氢等; R 3,R 4,R 13和R 14各自代表氢,C 1 -C 3酰基,卤素,羟基等; R 5表示氢,羟基化的C 1 -C 3烷基等; R 6表示C 1 -C 3 - 烷氧基取代的苯磺酰基等; 环Y代表苯基等; 环Z表示4-吡啶基及其氧化物等。
摘要:
A method for in vivo detecting a target protein gene by a drug, which comprises binding an antigenic substance to a drug to be administered to a living organism via a chemical crosslinker, using the obtained material as a probe, and directly screening the gene of the protein bonded to the above probe by using a cDNA expression library containing genes of the living organism to which the drug is to be administered. Compared with the conventional drug-fixed column methods, the above method makes it possible to directly and conveniently isolate the gene of the target molecule without resort to the purification of the protein and the analysis of the amino acid sequence thereof.
摘要:
Compounds represented by general formula (1), their salts, or solvates of both, and drugs containing the same, wherein A represents linear or branched alkylene; R1 represents hydrogen, hydroxy, alkoxy, alkyl, etc.; R2 represents hydrogen, alkyl, etc.; R3 represents hydrogen, alkyl, etc.; and R?4 and R5¿ are the same or different and each represents hydrogen, lower alkyl, etc. Because of having an inhibitory effect on the growth of viruses, these compounds are useful as remedies for AIDS.