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1.发明公开SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS -SECRETASE INHIBITORS 审中-公开取代的异喹啉衍生物，药物组合物，井井有条用作β-分泌酶抑制剂
公开(公告)号：EP2424533A4
公开(公告)日：2012-10-17
申请号：EP10770133
申请日：2010-04-20
发明人： MJALLI ADNAN M M , GADDAM BAPU , GOHIMUKKULA DEVI REDDY , POLISETTI DHARMA RAO , EL ABDELLAOUI HASSAN , RAO MOHAN , WANG PINGZHEN , ANDREWS ROBERT CARL , XIE RONGYUAN , REN TAN
IPC分类号： A61K31/47 , A61P25/28 , C07D401/12 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14
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2.发明公开SUBSTITUTED FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 有权取代的稠合咪唑衍生物，药物化合物及其使用方法
公开(公告)号：EP2536285A4
公开(公告)日：2014-01-22
申请号：EP11745064
申请日：2011-02-10
发明人： MJALLI ADNAN M M , POLISETTI DHARMA RAO , KASSIS JAREER NABEEL , KOSTURA MATTHEW J , GUZEL MUSTAFA , ATTUCKS OTIS CLINTON , ANDREWS ROBERT CARL , VICTORY SAMUEL , GUPTA SUPARNA
IPC分类号： A01N43/78 , A61K31/425 , C07D277/00 , C07D417/12
CPC分类号： C07D417/12 , C07D471/04
摘要： Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control of the activity or the amount or both the activity and the amount of heme-oxygenase.
摘要翻译： 取代的稠合咪唑衍生物，它们的制备方法，药物组合物，其包括稠合substituiertem咪唑衍生物，并提供治疗炎症的使用方法。 所述稠合substituiertem咪唑衍生物可以控制活性或量或二者的活性和血红素加氧的量。
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3.发明公开SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS 审中-公开取代的咪唑并[1,2-B]哒嗪衍生物，药物组合物和使用的方法ASβ-分泌酶抑制剂
公开(公告)号：EP2549874A4
公开(公告)日：2013-10-02
申请号：EP11759968
申请日：2011-03-21
发明人： MJALLI ADNAN M M , HARI ANITHA , GADDAM BAPU , GOHIMUKKULA DEVI REDDY , POLISETTI DHARMA RAO , RAO MOHAN , GOWDA RAJU BORE , ANDREWS ROBERT CARL , XIE RONGYUAN , SAHOO SOUMYA P , REN TAN , BANNER WILLIAM KENNETH
IPC分类号： A01N43/52 , A61K31/415
CPC分类号： C07D487/04 , C07D519/00
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4.发明公开TRICYCLIC COMPOUNDS AS MODULATORS OF TNF- SYNTHESIS AND AS PDE4 INHIBITORS 有权三环化合物作为TNF-α合成的调节剂和作为PDE4抑制剂的
公开(公告)号：EP2244574A4
公开(公告)日：2012-01-11
申请号：EP09704760
申请日：2009-01-23
IPC分类号： C07D239/42 , A01N43/54 , A61K31/505
CPC分类号： A61K31/519 , C07D471/04
摘要： The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-alpha or by PDE4, including but not limited to rheumatoid arthritis.
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