公开(公告)号：EP0865446A1

公开(公告)日：1998-09-23

申请号：EP96942315.0

申请日：1996-12-06

申请人： HOECHST MARION ROUSSEL

发明人： KITAMURA, Kazuyuki ,  KOMIYAMA, Osamu ,  INAZU, Mizuho ,  BARON, Roland ,  GADEK, Thomas ,  KNOLLE, Jochen ,  STILZ, Han-Ulrich ,  WEHNER, Volkmar ,  MCDOWELL, Robert, S.

IPC分类号： C07D233 ,  A61K31 ,  A61K38 ,  A61P19 ,  A61P43 ,  C07C271 ,  C07C279 ,  C07K5 ,  C07K7 ,  C07K14

CPC分类号： C07K5/0821 ,  A61K38/04 ,  A61K38/05 ,  A61K38/07 ,  A61K38/12 ,  A61K38/1703 ,  A61K38/39 ,  C07C271/22 ,  C07C279/08 ,  C07C279/20 ,  C07K5/0202 ,  C07K5/0817 ,  C07K5/1019 ,  C07K5/1024 ,  C07K14/46 ,  C07K14/745 ,  C07K14/78

摘要： The object is to provide a promoting agent for bone formation, a therapeutic method for bone formation and a process for preparing a promoting agent for bone formation. A promoting agent for bone formation which comprises at least one of kistrin, echstatin, a peptide or polypeptide containing the amino acid sequence ArgGlyAsp in the molecule such as a peptide represented by Gly-Arg-Gly-Asp-Ser or a compound represented by general formula (IX) and so on, as well as a biologically acceptable salt thereof, wherein R16 represents -N(R20)2 (R20 represents a hydrogen atom or a C1-C4 alkyl group), R17 represents a hydrogen atom or a C1-C4 alkyl group, R18 represents a hydrogen atom, a C1-C4 alkyl group and so on, R19 represents OH, NH2 and so on, Y represents -NH-, -O- or a direct bond, a represents 1-3, b represents 1 or 2, c represents 0 or 1 and d represents 0 or 1.