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1.发明公开
公开(公告)号：EP4414028A2
公开(公告)日：2024-08-14
申请号：EP24171629.9
申请日：2016-05-19
Applicant: Yale University
Inventor： BRADDOCK, Demetrios , ALBRIGHT, Ronald
IPC: A61P13/12
CPC classification number: A01K67/0271 , A01K2207/1520130101 , A01K2207/2020130101 , A01K2227/10520130101 , A01K2267/038720130101 , C07K14/745 , C07K2319/3020130101 , C07K2319/3120130101 , A61P9/10 , A61P13/12 , A61K38/46 , A61K38/465 , C12Y301/04001 , C12Y306/01009 , A61K38/04 , A61K38/1741 , C12N9/96 , C12N15/625 , A61K38/02
Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.
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公开(公告)号：EP3406242A1
公开(公告)日：2018-11-28
申请号：EP18180517.7
申请日：2011-08-17
Applicant: Yaqrit Limited
Inventor： JALAN, Rajiv , SHAH, Naina
CPC classification number: A61K38/10 , A61K38/04 , G01N33/6893 , G01N2333/705 , G01N2500/00 , G01N2800/085 , G01N2800/28 , G01N2800/347 , G01N2800/52
Abstract: The present invention derives from the finding that increased levels of Toll like receptor 4 (TLR4) is associated with liver failure and renal dysfunction and/or brain dysfunction and that by decreasing TLR4 levels in vivo, the kidney and brain consequences of liver disease that are precipitated by superimposed infection or inflammation may be reduced. Accordingly, the invention provides TLR4 antagonists for use in a method of treating an individual suffering from liver disease presenting with renal or brain dysfunction.
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公开(公告)号：EP2582715B1
公开(公告)日：2018-11-28
申请号：EP11796447.8
申请日：2011-06-16
Inventor： BOWERS, Cyril Y. , COY, David H. , HOCART, Simon J. , TANNENBAUM, Gloria S.
IPC: C07K7/08 , C07K7/06 , A61K38/10 , A61K38/08 , C07D471/10 , C07D471/04 , A61P35/00 , A61P3/00 , C07K14/72
CPC classification number: C07K7/08 , A61K38/00 , A61K38/03 , A61K38/04 , A61K38/08 , A61K38/10 , A61K38/16 , A61K38/25 , C07K5/06026 , C07K5/08 , C07K7/06 , C07K14/00 , C07K14/475 , C07K14/60 , C07K14/723
Abstract: The present invention provides novel peptides that can modulate the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and sub-types, isoforms and variants thereof). These peptides are useful as antagonists of the ghrelin receptor as well as inverse agonist, partial agonist or a combination of these activities as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, diabetes, central nervous system disorders, genetic disorders, and hyperpro-liferative disorders.
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公开(公告)号：EP2979703B1
公开(公告)日：2018-07-18
申请号：EP15179111.8
申请日：2008-11-05
Applicant: IPSEN PHARMA S.A.S. , Board of Supervisors of Louisiana State University and Agriculture and Mechanical College
Inventor： HALEM, Heather A. , CULLER, Michael Dewitt , BUTLER, Andrew A.
IPC: A61K38/00
Abstract: The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as insulin resistance.
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5.发明授权Pharmaceutical composition comprising lacosamide and levetiracetam with synergistic anticonvulsant effect 有权包含lacosamide和左乙拉西坦的药物组合物，具有协同抗惊厥作用
公开(公告)号：EP2462990B2
公开(公告)日：2018-04-18
申请号：EP12001535.9
申请日：2007-06-15
Applicant: UCB Pharma GmbH
Inventor： Stöhr, Thomas
IPC: A61P25/08 , A61K31/165 , A61K31/4015 , A61K38/05 , A61K45/06
CPC classification number: A61K31/19 , A61K31/165 , A61K31/195 , A61K31/35 , A61K31/40 , A61K31/4015 , A61K31/4166 , A61K31/53 , A61K31/55 , A61K38/04 , A61K38/05 , A61K45/06 , B65D81/32
Abstract: The present invention is directed to a pharmaceutical composition comprising (a) lacosamide and (b) levetiracetam for the prevention, alleviation or/and treatment of epileptic seizures.
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Patent Agency Ranking
公开(公告)号：EP3185885A4
公开(公告)日：2018-04-04
申请号：EP15836989
申请日：2015-08-26
Applicant: COMPUGEN LTD
Inventor： HECHT IRIS , NERIA EYAL , ROTMAN GALIT , MILLER STEPHEN D , PODOJIL JOSEPH R
IPC: A61K38/17 , A61K38/00 , A61K38/04 , A61K39/395 , A61P37/06 , C07K14/705 , C07K16/46
CPC classification number: C07K14/4713 , A61K38/00 , A61K38/04 , A61K38/17 , A61K39/39541 , A61K2039/505 , C07K14/54 , C07K14/70503 , C07K16/2866 , C07K2319/00 , C07K2319/30 , G01N33/564 , G01N33/6863 , G01N2800/52 , A61K2300/00
Abstract: This invention, in at least some embodiments, relates to a protein C1ORF32 and its variants and fragments and fusion proteins thereof, and methods of use thereof for immunotherapy, and drug development, including but not limited to as immune modulators and for immune therapy, including for autoimmune disorders.
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公开(公告)号：EP3263125A3
公开(公告)日：2018-03-14
申请号：EP17178437.4
申请日：2012-01-31
Applicant: Emory University
Inventor： WALLER, Edmund, K. , HOSSAIN, Mohammad, S. , LI, Jian-Ming
IPC: A61K38/22 , A61K39/245 , A61K39/395 , A61K35/14 , A61K35/17 , A61P31/12 , A61P31/16 , A61P35/00 , A61P35/02
CPC classification number: A61K39/3955 , A61K35/14 , A61K35/17 , A61K38/04 , A61K38/16 , A61K38/2278 , A61K39/245 , Y02A50/467
Abstract: The disclosure relates to inhibition of the VIP signaling pathway. In certain embodiments, the disclosure relates to methods of treating or preventing a viral infection comprising administering a VIP antagonist to a subject in need thereof.
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公开(公告)号：EP3236992A1
公开(公告)日：2017-11-01
申请号：EP15868680.8
申请日：2015-09-03
Applicant: AVON PRODUCTS, INC.
Inventor： IDKOWIAK BALDYS, Jolanta , SANTHANAM, Uma
CPC classification number: A61K8/64 , A61K8/36 , A61K8/365 , A61K8/49 , A61K38/04 , A61Q19/08 , C07K5/08 , C07K5/10 , C07K7/00
Abstract: Embodiments of the invention are related generally to the methods of diminishing the signs of aging in and/or improving health of human integuments, such as skin, and compositions comprising peptides useful therefor. The compositions according to the invention may comprise one or more peptides or fragments or derivatives thereof derived from a growth factor, e.g., Growth Differentiation Factor 11 (GDF11), in a topically acceptable vehicle.
Abstract translation: 本发明的实施方案一般涉及减少人体皮肤老化迹象和/或改善人体皮肤健康的方法，以及包含对其有用的肽的组合物。 根据本发明的组合物可以包含衍生自生长因子例如生长分化因子11（GDF11）的一种或多种肽或其片段或衍生物在局部可接受的载体中。
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公开(公告)号：EP3206704A1
公开(公告)日：2017-08-23
申请号：EP15851584.1
申请日：2015-10-13
Applicant: Riptide Bioscience, Inc.
Inventor： JAYNES, Jesse M. , LOPEZ, Henry W. , MARTIN, George R. , YATES, Clayton , GARVIN, Charles E.
CPC classification number: A61K38/08 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/7068 , A61K36/10 , A61K38/04 , A61K38/10 , A61K38/16 , A61K45/06 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00
Abstract: Aspects of the present invention relate to peptides having anti-inflammatory activity, compositions containing one or more of the peptides, and use of the peptides to treat conditions associated with excessive inflammation in animals, particularly humans and other mammals.
Abstract translation: 本发明的方面涉及具有抗炎活性的肽，含有一种或多种肽的组合物，以及该肽用于治疗动物特别是人和其他哺乳动物中与过度炎症有关的病症的用途。
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公开(公告)号：EP3206703A1
公开(公告)日：2017-08-23
申请号：EP15788259.8
申请日：2015-10-13
Applicant: The U.S.A. as represented by the Secretary, Department of Health and Human Services , Riptide Bioscience, Inc.
Inventor： RUDLOFF, Udo , JAYNES, Jesse, M. , LOPEZ, Henry, W. , MARTIN, George, R. , YATES, Clayton
CPC classification number: A61K38/08 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/7068 , A61K36/10 , A61K38/04 , A61K38/10 , A61K38/16 , A61K45/06 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00
Abstract: Aspects of the present invention relate to peptides having anti-inflammatory activity, compositions containing one or more of the peptides, and use of the peptides to treat conditions associated with excessive inflammation in animals, particularly humans and other mammals.
Abstract translation: 本发明的方面涉及具有抗炎活性的肽，含有一种或多种肽的组合物，以及该肽用于治疗动物特别是人和其他哺乳动物中与过度炎症有关的病症的用途。
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