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1.发明公开Alkylamino- and alkylaminoalkyl diarylketones, a process for their preparation and their use as medicaments 失效烷基和Alkylaminoalkyldiarylketone，其制备方法及其作为一种补救措施使用。
公开(公告)号：EP0432719A1
公开(公告)日：1991-06-19
申请号：EP90123796.6
申请日：1990-12-11
IPC分类号： C07C225/22 , C07C225/16 , C07C221/00 , C07C217/86 , A61K31/135
CPC分类号： C07C225/22 , C07C45/004 , C07C45/455 , C07C49/233 , C07C49/80 , C07C217/86 , C07C225/16
摘要： This invention relates to alkylamino and alkyl amino alkyl diarylketones of the formula
where Ar is aryl of the formula
where V is hydrogen, halogen, loweralkyl, loweralkoxy, CF₃, NO₂ and u is an integer of 1 to 3; X and Y are independently CH₂-, -CF₂- or -CHF-; Z and W are independently -CH₂-, -O-, -CHOH-, or -CHF-; m, n, p, q and t are integers which are independently 0 or 1; R₁ is H or loweralkyl; R₂ and R₃ are loweralkyl; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic agents and as agents for alleviating various memory dysfunctions, characterized by a decreased cholinergic function, such as Alzheimer's disease.摘要翻译： 本发明涉及烷基氨基和式
其中Ar是下式 其中V是氢，卤素，低级烷基，低级烷氧基，CF 3的芳基的烷基氨基烷基二芳基，NO 2和u是1至3的整数; X和Y独立地是-CH 2 - 或-CF 2 -CHF-; Z和W独立地是-CH 2 - ，-O - ， - -CHOH-，或-CHF-; M，N，p，q和t均为整数哪个独立为0或1; R 1是H或低级烷基; R2和R3是低级烷基; 和其药学上可接受的酸加成盐和如果适用的几何和光学异构体和外消旋混合物。 如阿尔茨海默氏病：本发明显示可用作止痛剂和作为用于减轻各种存储器功能障碍，由降低的胆碱能功能，颜色为特征的药剂的化合物。
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