IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS
    1.
    发明公开
    IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS 失效
    改进的造影剂。

    公开(公告)号:EP0660724A1

    公开(公告)日:1995-07-05

    申请号:EP93919497.0

    申请日:1993-09-03

    IPC分类号: A61K49

    摘要: Proteinaceous gas- or gas precursor-containing microbubble contrast agents, e.g. for use in ultrasound and/or MR imaging, in which the protein matrix is crosslinked by reaction with a bifunctional aldehyde (e.g. a dialdehyde such as glutaraldehyde or an α,β-unsaturated aldehyde such as acrolein) in an aqueous medium at substantially neutral pH exhibit improved in vivo and storage stabilities, particularly if the matrix is also reacted with a Schiff's base reducing agent such as a borohydride. Modification of the size distribution of such crosslinked proteinaceous gas-containing contrast agents, e.g. to reduce the mean size of the microbubbles, further enhances their stability and permits preparation of novel contrast agents having a particularly narrow microbubble size distribution.