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1.发明公开METHOD FOR PREPARING DENDRITIC CELL LOADED WITH ANTIGEN 审中-公开VERFAHREN ZUR HERSTELLUNG EINER DENDRITISCHEN，MIT ANTIGEN BELADENEN ZELLE
公开(公告)号：EP3145538A1
公开(公告)日：2017-03-29
申请号：EP15796798.5
申请日：2015-05-20
发明人： MA, Yifan , ZHOU, Xiangjun , CHEN, Shang , CAI, Lintao , WANG, Ce , LIU, Peng
IPC分类号： A61K39/00 , A61K47/34 , A61K47/26 , C12N5/0784 , A61P35/00
CPC分类号： A61K39/0011 , A61K39/12 , A61K39/292 , A61K2039/5154 , A61K2039/55555 , C12N5/0639 , C12N7/00 , C12N2500/90 , C12N2501/05 , C12N2501/22 , C12N2501/2304 , C12N2730/10134
摘要： The present invention provides a method for preparing dendritic cell loaded with antigen, the method comprising the steps of adding serum-free cell culture medium containing granulocyte-macrophage colony-stimulating factor (GM-CSF) and inter-leukin (IL)-4 into mononuclear cells, culturing in an incubator at 37° C. under 5% carbon dioxide for 5 days, adding target antigen wrapped cationic liposome and culturing for 8-24 hours to obtain target antigen loaded dendritic cell.
摘要翻译： 本发明提供了一种制备负载抗原的树突细胞的方法，所述方法包括将含有粒细胞 - 巨噬细胞集落刺激因子（GM-CSF）和白细胞介素（IL）-4的无血清细胞培养基加入到单核细胞中 ，在37℃，5％二氧化碳培养箱中培养5天，加入靶抗原包裹的阳离子脂质体，培养8-24小时，得到靶向抗原的树突状细胞。
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公开(公告)号：EP3268465A1
公开(公告)日：2018-01-17
申请号：EP16764215.6
申请日：2016-03-11
申请人： Syz Cell Therapy Co.
发明人： ZHOU, Xiangjun , LI, Jin , HAN, Yanyan , WU, Dongyun , LIU, Junyun , TAO, Ran , TANG, Longqing
IPC分类号： C12N5/0783 , C12N5/0784 , C12N5/0786 , A61K38/17 , A61P35/00
CPC分类号： A61K39/0011 , A61K35/14 , A61K35/17 , A61K45/06 , A61K2039/5154 , A61K2039/5158 , C12N5/0636 , C12N5/0639 , C12N2501/998 , C12N2502/1114 , C12N2502/1121
摘要： Provided is a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Also provided are precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual, methods of preparing the activated T cells, methods of monitoring the treatment, methods of cloning tumor-specific T cell receptors, an isolated population of cells comprising the activated T cells, and compositions and kits useful for cancer immunotherapy.
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公开(公告)号：EP4219690A2
公开(公告)日：2023-08-02
申请号：EP23156772.8
申请日：2016-03-11
申请人： SYZ Cell Therapy Co.
发明人： ZHOU, Xiangjun , LI, Jin , HAN, Yanyan , WU, Dongyun , LIU, Junyun , TAO, Ran , TANG, Longqing
IPC分类号： C12N5/0783 , C12N5/0784 , C12N5/0786 , A61K38/17 , A61P35/00
摘要： Provided is a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Also provided are precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual, methods of preparing the activated T cells, methods of monitoring the treatment, methods of cloning tumor-specific T cell receptors, an isolated population of cells comprising the activated T cells, and compositions and kits useful for cancer immunotherapy.
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公开(公告)号：EP3775168A1
公开(公告)日：2021-02-17
申请号：EP19785434.2
申请日：2019-04-12
发明人： ZHOU, Xiangjun , HAN, Yanyan , LIANG, Xiaoling , CHEN, Xihe
IPC分类号： C12N5/0783 , C12N5/0784 , C12N5/0786 , A61K38/17 , A61P35/00
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公开(公告)号：EP4219690A3
公开(公告)日：2023-08-30
申请号：EP23156772.8
申请日：2016-03-11
申请人： SYZ Cell Therapy Co.
发明人： ZHOU, Xiangjun , LI, Jin , HAN, Yanyan , WU, Dongyun , LIU, Junyun , TAO, Ran , TANG, Longqing
IPC分类号： C12N5/0783 , C12N5/0784 , C12N5/0786 , A61K38/17 , A61P35/00
摘要： Provided is a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Also provided are precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual, methods of preparing the activated T cells, methods of monitoring the treatment, methods of cloning tumor-specific T cell receptors, an isolated population of cells comprising the activated T cells, and compositions and kits useful for cancer immunotherapy.
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公开(公告)号：EP3775167A1
公开(公告)日：2021-02-17
申请号：EP19784760.1
申请日：2019-04-12
发明人： ZHOU, Xiangjun , HAN, Yanyan , CHEN, Xihe , LIANG, Xiaoling
IPC分类号： C12N5/0783 , C12N5/0784 , A61K39/00 , A61P35/00
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公开(公告)号：EP3775166A1
公开(公告)日：2021-02-17
申请号：EP19777370.8
申请日：2019-03-29
发明人： ZHOU, Xiangjun , MA, Yifan , HAN, Yanyan , LI, Jin , TANG, Longqing , LIU, Junyun , WU, Dongyun
IPC分类号： C12N5/0783 , C12N5/0784 , A61K35/17 , A61K38/17 , A61P35/00
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