公开(公告)号：EP0777493A1

公开(公告)日：1997-06-11

申请号：EP95909511.0

申请日：1995-02-03

申请人： HUMAN GENOME SCIENCES, INC. ,  SMITHKLINE BEECHAM CORPORATION

发明人： ADAMOU, John ,  AIYAR, Nambi ,  BERGSMA, Derk ,  ELSHOURBAGY, Nabil ,  LI, Yi ,  LEE, Norman H.

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61K48 ,  A61P1 ,  A61P3 ,  A61P9 ,  A61P11 ,  A61P13 ,  A61P15 ,  A61P25 ,  A61P29 ,  A61P35 ,  A61P37 ,  A61P43 ,  C07H21 ,  C07K7 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12P21 ,  C12Q1 ,  G01N33 ,  C12R1

CPC分类号： C07K14/723 ,  A61K38/00 ,  C07K14/72 ,  C12N2799/026

摘要： A human CGRP receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat cancer, arthritis, pain, diabetes, migraine and inflammation and agonists which may be used to treat hypercalcemia, obesity, hypertension, and disorders of bone remodelling. Diagnostic assays are also disclosed which detect the presence of mutations in the nucleic acid sequences which encode the receptor polypeptide.