公开(公告)号：EP0777493A1

公开(公告)日：1997-06-11

申请号：EP95909511.0

申请日：1995-02-03

申请人： HUMAN GENOME SCIENCES, INC. ,  SMITHKLINE BEECHAM CORPORATION

发明人： ADAMOU, John ,  AIYAR, Nambi ,  BERGSMA, Derk ,  ELSHOURBAGY, Nabil ,  LI, Yi ,  LEE, Norman H.

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61K48 ,  A61P1 ,  A61P3 ,  A61P9 ,  A61P11 ,  A61P13 ,  A61P15 ,  A61P25 ,  A61P29 ,  A61P35 ,  A61P37 ,  A61P43 ,  C07H21 ,  C07K7 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12P21 ,  C12Q1 ,  G01N33 ,  C12R1

CPC分类号： C07K14/723 ,  A61K38/00 ,  C07K14/72 ,  C12N2799/026

摘要： A human CGRP receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat cancer, arthritis, pain, diabetes, migraine and inflammation and agonists which may be used to treat hypercalcemia, obesity, hypertension, and disorders of bone remodelling. Diagnostic assays are also disclosed which detect the presence of mutations in the nucleic acid sequences which encode the receptor polypeptide.

公开(公告)号：EP1212347A1

公开(公告)日：2002-06-12

申请号：EP00912077.5

申请日：2000-03-01

申请人： SmithKline Beecham Corporation

发明人： ELSHOURBAGY, Nabil ,  SHABON, Usman ,  MICHALOVICH, David

IPC分类号： C07K1/00 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/723 ,  C07K14/715

摘要： AXOR23 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR23 polypeptides and polynucleotides in diagnostic assays.

摘要翻译： 公开了AXOR23多肽和多核苷酸以及通过重组技术生产这些多肽的方法。 还公开了在诊断测定中利用AXOR23多肽和多核苷酸的方法。

公开(公告)号：EP1071708A1

公开(公告)日：2001-01-31

申请号：EP99918524.2

申请日：1999-04-14

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： BERGSMA, Derk, J. ,  ELSHOURBAGY, Nabil ,  LANE, Pamela ,  LI, Xiaotong ,  MOONEY, Jeffrey, L. ,  TSUI, Ping

IPC分类号： C07K14/435 ,  C07K14/47 ,  C07K14/705 ,  C12N5/10 ,  C12N15/85 ,  G01N33/53 ,  G01N33/566

CPC分类号： C07K14/723 ,  A61K38/00

摘要： Human H218 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human H218 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

公开(公告)号：EP1196578A1

公开(公告)日：2002-04-17

申请号：EP00952151.9

申请日：2000-07-14

申请人： SMITHKLINE BEECHAM CORPORATION ,  SMITHKLINE BEECHAM PLC

发明人： LANE, Pamela ,  ELSHOURBAGY, Nabil ,  MICHALOVICH, David ,  PANGALOS, Menelas ,  ROBBINS, Melanie

IPC分类号： C12N15/12 ,  C07K14/705 ,  C07K16/28

摘要： AXOR39 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR39 polypeptides and polynucleotides in diagnostic assays.

公开(公告)号：EP1104440A1

公开(公告)日：2001-06-06

申请号：EP99918690.1

申请日：1999-04-20

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： BERGSMA, Derk ,  ELSHOURBAGY, Nabil ,  SHABON, Usman

IPC分类号： C07K14/705

CPC分类号： C07K14/723 ,  A61K38/00

摘要： AXOR-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR-1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

公开(公告)号：EP1129101A1

公开(公告)日：2001-09-05

申请号：EP99972639.1

申请日：1999-11-17

申请人： SmithKline Beecham Corporation

发明人： SHABON, Usman ,  ELSHOURBAGY, Nabil ,  MICHALOVICH, David

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K48/00 ,  A61K49/00 ,  C12N15/00 ,  C12N15/63 ,  C12N15/86 ,  C12N5/02 ,  C12N15/85 ,  C12N5/00 ,  C07K14/00 ,  C07K16/00 ,  A01N37/18 ,  A01N61/00 ,  C12Q1/68 ,  C12Q1/00

CPC分类号： C07K14/705 ,  A61K48/00

摘要： AXOR15 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR15 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

公开(公告)号：EP1104483A1

公开(公告)日：2001-06-06

申请号：EP99935816.1

申请日：1999-07-22

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： ELSHOURBAGY, Nabil ,  SHABON, Usman

IPC分类号： C12P15/00 ,  C07K14/47 ,  C07K14/705

CPC分类号： C07K14/723 ,  A61K38/00

摘要： GPR31A polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing GPR31A polypeptides and polynucleotides in therapy, and diagnostic assays for such.

公开(公告)号：EP1100813A1

公开(公告)日：2001-05-23

申请号：EP99935717.1

申请日：1999-07-20

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： LANE, Pamela ,  ELSHOURBAGY, Nabil ,  TSUI, Ping

IPC分类号： C07K5/00

CPC分类号： C07K14/70571 ,  A61K38/00

摘要： Bombesin receptor subtype-3sb polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Bombesin receptor subtype-3sb polypeptides and polynucleotides in therapy, and diagnostic assays for such.

公开(公告)号：EP1189944A1

公开(公告)日：2002-03-27

申请号：EP00942952.3

申请日：2000-06-19

申请人： SmithKline Beecham Corporation

发明人： ELSHOURBAGY, Nabil ,  SHABON, Usman

IPC分类号： C07K14/705 ,  C07K16/28 ,  C12N15/12

CPC分类号： C07K14/705

摘要： The AXOR16 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR16 polypeptides and polynucleotides in diagnostic assays.

公开(公告)号：EP1171467A1

公开(公告)日：2002-01-16

申请号：EP00928449.8

申请日：2000-04-26

申请人： SmithKline Beecham Corporation ,  SMITHKLINE BEECHAM PLC

发明人： MICHALOVICH, David ,  ELSHOURBAGY, Nabil ,  TAN, Kong, B.

IPC分类号： C07K14/705 ,  C07K16/18 ,  C12N5/10 ,  C12N5/16 ,  C12N15/12 ,  C12N15/63 ,  C12N15/64

CPC分类号： C07K14/723

摘要： AXOR27 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR27 polypeptides and polynucleotides in diagnostic assays.