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公开(公告)号：EP3681877A1
公开(公告)日：2020-07-22
申请号：EP18856659.0
申请日：2018-09-13
发明人： BAE, In Hwan , KIM, Ji Sook , KIM, Won Jeoung , PARK, Chang Hee , SONG, Ji Young , AHN, Young Gil
IPC分类号： C07D401/06 , A61K31/454 , A61K9/00
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2.发明公开
公开(公告)号：EP3991733A1
公开(公告)日：2022-05-04
申请号：EP20833623.0
申请日：2020-06-25
发明人： BAE, In Hwan , SONG, Ji Young , CHOI, Jae Yul , AHN, Young Gil
IPC分类号： A61K31/506 , A61K31/496 , A61K45/06 , A61P35/02
摘要： Provided are: a pharmaceutical composition for treating myeloid leukemia (AML), and a method for treating acute myeloid leukemia using same, the pharmaceutical composition comprising a therapeutically effective combination of an Fms-like tyrosine kinase-3 (FLT3) inhibitor or pharmaceutically acceptable salt or solvate thereof, and a chemotherapeutic agent or pharmaceutically acceptable salt or solvate thereof.
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公开(公告)号：EP4241773A1
公开(公告)日：2023-09-13
申请号：EP21889548.0
申请日：2021-11-03
发明人： BAE, In Hwan , SONG, Ji Young , CHOI, Jae Yul , AHN, Young Gil
IPC分类号： A61K31/506 , A61K45/06 , A61P35/02 , C12Q1/6886
摘要： [Summary]
The present invention relates to a pharmaceutical composition for the treatment of leukemia comprising an FMS-like tyrosine kinase-3 (FLT3) inhibitor and a pharmaceutically acceptable excipient.-
公开(公告)号：EP3907225A1
公开(公告)日：2021-11-10
申请号：EP20749014.5
申请日：2020-01-31
发明人： BAE, In Hwan , KIM, Won Jeoung , KIM, Ji Sook , SONG, Ji Young , CHOI, Jae Yul , KIM, Min Jeong , NAM, Jung Soo , AHN, Young Gil
IPC分类号： C07D471/04 , A61K31/4545 , A61P35/00
摘要： One aspect of the present invention provides a compound selected from among a compound of chemical formula 1 having lysine-specific demethylase-1 (LSD1) inhibitory activity, and a tautomer, a stereoisomer, and a solvate thereof, and pharmaceutically acceptable salts of the aforementioned components, and said compound is effective in the prevention or treatment of diseases caused by abnormal activation of LSD1.
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公开(公告)号：EP3689942A1
公开(公告)日：2020-08-05
申请号：EP18860767.5
申请日：2018-10-01
发明人： PARK, Su Yeon , SONG, Ji Young , KIM, Eun Jung , LEE, Jong Min , LEE, Jong-Soo , KIM, Dae Jin
IPC分类号： C08G65/325 , C07K14/62 , A61K47/54 , A61K47/56
摘要： Provided are a protein conjugate in which a physiologically active polypeptide is linked to a biocompatible material via a non-peptidyl polymer-coupled fatty acid derivative compound serving as a linker, exhibiting an increased duration of physiological activity compared to natural forms and a preparation method therefor. Since an increase in serum half-life of the physiologically active polypeptide of the protein conjugate, in which the biocompatible material, the non-peptidyl polymer-coupled fatty acid derivative compound, and the physiologically active polypeptide are linked, is proved, the protein conjugate may be widely used in the field of protein drugs.
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公开(公告)号：EP3617213A1
公开(公告)日：2020-03-04
申请号：EP19198802.1
申请日：2012-12-27
发明人： BAE, In Hwan , SON, Jung Beom , HAN, Sang Mi , KWAK, Eun Joo , KIM, Ho Seok , SONG, Ji Young , BYUN, Eun Young , JUN, Seung Ah , AHN, Young Gil , SUH, Kwee Hyun
IPC分类号： C07D495/04 , A61K31/519 , A61P35/00 , C07D519/00 , A61K31/5377 , A61K45/06
摘要： Provided are a method of preparing a thieno[3,2-d]pyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof, a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising the same for prevention and treatment of abnormal cell growth diseases.
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7.发明公开BICYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME 审中-公开药剂师联合会药剂师ZUSAMMENSETZUNG DAMIT
公开(公告)号：EP3143017A1
公开(公告)日：2017-03-22
申请号：EP15792426.7
申请日：2015-05-08
发明人： KIM, Ji Sook , KIM, Won Jeoung , JANG, Wook , SONG, Ji Young , LEE, Moon Sub , KIM, Nam Du , SUH, Kwee Hyun
IPC分类号： C07D407/04 , C07D309/10 , A61K31/343 , A61K31/34 , A61K31/35 , A61P3/10
CPC分类号： C07D407/14 , C07D309/10 , C07D407/04 , C07D407/10 , C07D409/10 , C07H7/04
摘要： The present invention relates to a novel bicyclic derivative that has an inhibitory activity against sodium-glucose linked transporters (SGLTs) present in the intestines and kidneys, or a pharmaceutically acceptable salt, isomer, hydrate or solvate thereof, and a pharmaceutical composition including the same as an active ingredient, which effectively inhibit the SGLT activity, and thus can be used as a therapeutic agent to treat diseases caused by hyperglycemia, such as diabetes including insulin-dependent diabetes (type I diabetes mellitus) and non-insulin-dependent diabetes (type II diabetes mellitus), diabetic complications, and obesity.
摘要翻译： 本发明涉及对存在于肠和肾中的钠 - 葡萄糖连接转运蛋白（SGLT）或其药学上可接受的盐，异构体，水合物或溶剂合物具有抑制活性的新型双环衍生物，以及包含其的药物组合物 作为有效抑制SGLT活性的活性成分，因此可以用作治疗由高血糖引起的疾病的治疗剂，例如包括胰岛素依赖性糖尿病（I型糖尿病）和非胰岛素依赖型糖尿病（I型糖尿病） II型糖尿病），糖尿病并发症和肥胖。
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8.发明公开THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES 审中-公开带有锁定对蛋白激酶噻吩并[3,2-D]嘧啶衍生物
公开(公告)号：EP2797927A1
公开(公告)日：2014-11-05
申请号：EP12861811.3
申请日：2012-12-27
发明人： BAE, In Hwan , SON, Jung Beom , HAN, Sang Mi , KWAK, Eun Joo , KIM, Ho Seok , SONG, Ji Young , BYUN, Eun Young , JUN, Seung Ah , AHN, Young Gil , SUH, Kwee Hyun
IPC分类号： C07D495/04 , C07D417/12 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.
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