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公开(公告)号：EP3333157A1
公开(公告)日：2018-06-13
申请号：EP16834592.4
申请日：2016-08-03
发明人： CHEN, Shuhui , CHEN, Zhengxia , DAI, Meibi , XIE, Cheng , LI, Peng , ZHANG, Yang , LIANG, Guibai , WANG, Qiang , LIAO, Jiangpeng , SUN, Fei , HU, Guoping , LI, Jian
IPC分类号： C07D235/02 , C07D401/02 , C07D401/14 , C07D403/02 , C07D403/14 , A61K31/395 , A61K31/416 , A61P35/00
CPC分类号： C07D401/14 , A61K31/395 , A61K31/416 , A61P35/00 , C07D235/02 , C07D401/02 , C07D401/12 , C07D403/02 , C07D403/14 , C07D405/14 , C07D413/14
摘要： FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.
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公开(公告)号：EP3919477A1
公开(公告)日：2021-12-08
申请号：EP20749071.5
申请日：2020-02-03
发明人： ZHANG, Yang , XIA, Yuanfeng , SUN, Deheng , ZUO, Jian , CHEN, Zhengxia , DAI, Meibi , LI, Jian , CHEN, Shuhui
IPC分类号： C07D235/02 , C07D401/02 , C07D401/14 , C07D403/02 , C07D403/14 , A61K31/395 , A61K31/416 , A61P35/00
摘要： The present invention relates to a PD-L1 immunomodulator, and specifically discloses a compound of formula (I) as a PD-L1 immunomodulator, a pharmaceutically acceptable salt or an isomer thereof.
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公开(公告)号：EP3950685A1
公开(公告)日：2022-02-09
申请号：EP20782515.9
申请日：2020-04-03
申请人： Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory , Medshine Discovery Inc.
发明人： WANG, Jiansong , CHEN, Zhengxia , LUO, Zhibo , DAI, Meibi , ZHANG, Yang , CHEN, Shuhui , BAO, Yingxia , WANG, Wei , XIE, Zhoufan
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Disclosed is a series of pyrazolopyridine compounds, and application thereof in the preparation of RET kinase inhibitors for treatment. Specifically disclosed is the compound represented by formula (I), or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP3825314A1
公开(公告)日：2021-05-26
申请号：EP19837159.3
申请日：2019-07-19
发明人： ZHANG, Yang , CHEN, Zhengxia , WANG, Yikai , DAI, Meibi , LI, Jie , GONG, Zhen , LI, Jian , CHEN, Shuhui
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： A series of pyrazolopymidine derivatives, and use thereof in the preparation of a medicament for treating disease associated with FGFR and c-Met. The pyrazolopymidine derivative is a compound represented by formula (I), a tautomer, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4006027A1
公开(公告)日：2022-06-01
申请号：EP20847841.2
申请日：2020-07-24
发明人： CHEN, Zhengxia , DAI, Meibi , ZHANG, Yang , CHEN, Shuhui
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： FGFR and VEGFR dual inhibitors, specifically being a compound represented by formula (I) or a pharmaceutically acceptable salt.
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公开(公告)号：EP3985005A1
公开(公告)日：2022-04-20
申请号：EP20823692.7
申请日：2020-06-12
发明人： CHEN, Zhengxia , TAN, Haizhong , ZHANG, Yang , LI, Jian , CHEN, Shuhui
IPC分类号： C07D471/04 , A61K31/416 , A61P35/00
摘要： A fused ring compound as an FGFR and VEGFR dual inhibitor. Particularly, disclosed is a compound represented by formula (III) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4166551A1
公开(公告)日：2023-04-19
申请号：EP21813193.6
申请日：2021-05-24
发明人： CHEN, Shuhui , CHEN, Zhengxia
IPC分类号： C07D403/02 , C07D403/06 , C07D403/14 , C07D401/02 , C07D249/12 , A61K31/4196 , A61P35/00
摘要： The present invention discloses a series of triazolone compounds, and specifically discloses a compound and a pharmaceutically acceptable salt thereof as shown in formula (V).
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公开(公告)号：EP3919478A1
公开(公告)日：2021-12-08
申请号：EP20749526.8
申请日：2020-02-03
发明人： ZHANG, Yang , XIA, Yuanfeng , CHEN, Zhengxia , DAI, Meibi , SUN, Deheng , ZUO, Jian , LI, Jian , CHEN, Shuhui
IPC分类号： C07D235/02 , C07D403/14 , A61K31/395 , A61P35/00
摘要： Disclosed is a PD-L1 inhibitor, and specifically disclosed is a compound of formula (I) as a PD-L1 immunomodulator, a pharmaceutically acceptable salt or an isomer thereof.
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公开(公告)号：EP3689351A1
公开(公告)日：2020-08-05
申请号：EP18862179.1
申请日：2018-09-20
发明人： ZHANG, Yang , CHEN, Zhengxia , DAI, Meibi , LI, Wenju , LI, Jian , CHEN, Shuhui
摘要： A quinoline derivative compound shown in formula (II), a pharmaceutically acceptable salt thereof, and an application of the same in preparing a drug for treating a disease related to a tyrosine kinase inhibitor.
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