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公开(公告)号：EP1587520B1
公开(公告)日：2009-08-12
申请号：EP04701383.4
申请日：2004-01-12
发明人： SHARP, Richard , HUGHES, Gavin , HART, A., Deptartment of Medical Microbiology and , WALKER, James Taggart
CPC分类号： A61K35/76 , A61K38/51 , C12N7/00 , C12N9/88 , C12N2795/00032 , C12N2795/10032 , C12N2795/10043 , C12Y402/02003 , A61K2300/00
摘要： The present invention provides a composition for treating a bacterial biofilm, comprising a first bacteriophage that is capable of infecting a bacterium within said biofilm, and a first polysaccharide lyase enzyme that is capable of degrading a polysaccharide within said biofilm. The composition preferably further comprises a pharmaceutically-acceptable antimicrobial agent, and may also include a DNase. Also provided are modified bacteriophages, methods of creating modified bacteriophages, use of said compositions and bacteriophage for treating biofilms, and methods for treating biofilms using the bacteriophages and compositions of the invention.
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公开(公告)号：EP1587520A1
公开(公告)日：2005-10-26
申请号：EP04701383.4
申请日：2004-01-12
发明人： SHARP, Richard , HUGHES, Gavin , HART, A.,Deptartment of Medical Microbiology and , WALKER, James Taggart
CPC分类号： A61K35/76 , A61K38/51 , C12N7/00 , C12N9/88 , C12N2795/00032 , C12N2795/10032 , C12N2795/10043 , C12Y402/02003 , A61K2300/00
摘要： The present invention provides a composition for treating a bacterial biofilm, comprising a first bacteriophage that is capable of infecting a bacterium within said biofilm, and a first polysaccharide lyase enzyme that is capable of degrading a polysaccharide within said biofilm. The composition preferably further comprises a pharmaceutically-acceptable antimicrobial agent, and may also include a DNase. Also provided are modified bacteriophages, methods of creating modified bacteriophages, use of said compositions and bacteriophage for treating biofilms, and methods for treating biofilms using the bacteriophages and compositions of the invention.
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