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公开(公告)号：EP1071460A4
公开(公告)日：2004-09-08
申请号：EP99919786
申请日：1999-04-23
申请人： UNIV CALIFORNIA
发明人： MARKS JAMES D , POUL MARIE ALIX
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61P35/00 , C07K14/01 , C07K16/28 , C07K16/32 , C07K19/00 , C12N15/86
CPC分类号： A61K47/48823 , A61K9/0019 , A61K31/704 , A61K38/00 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K47/6855 , A61K47/6865 , A61K47/6913 , C07K16/2863 , C07K16/2881 , C07K16/3053 , C07K16/32 , C07K2317/10 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/77 , C07K2317/92 , C07K2319/02 , C12N15/86 , C12N2795/10043 , C12N2810/859 , Y10S424/812
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2.发明公开IMPROVED TRANSFORMATION EFFICIENCY IN PHAGE DISPLAY THROUGH MODIFICATION OF A COAT PROTEIN 审中-公开提高PHAG显示转化效率通过修改包膜蛋白
公开(公告)号：EP1100890A2
公开(公告)日：2001-05-23
申请号：EP99935837.7
申请日：1999-07-22
申请人： Genentech, Inc.
CPC分类号： C40B40/02 , C07K14/005 , C07K2319/00 , C12N15/1037 , C12N2795/10022 , C12N2795/10043
摘要： The transformation yield of electroporation is increased by using higher DNA concentrations and DNA affinity purification. Fusion proteins of a viral coat protein variant and a heterologous polypeptide are useful in phage display systems.
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公开(公告)号：EP2997148B1
公开(公告)日：2018-11-21
申请号：EP14723873.7
申请日：2014-05-12
发明人： HAJITOU, Amin , YATA, Teerapong
CPC分类号： A61K35/76 , C07K2319/00 , C07K2319/09 , C07K2319/74 , C12N15/86 , C12N2795/10043 , C12N2795/10045
摘要： The invention provides a recombinant targeted bacteriophage for expressing a transgene in a target cell transduced with the bacteriophage. The bacteriophage comprises a first nucleic acid sequence encoding a pill capsid minor coat protein that is configured to display a cell-targeting ligand for enabling delivery of the bacteriophage to a target cell, a second nucleic acid sequence encoding at least one pVIII capsid major coat protein that is configured to display a foreign peptide thereon, and a transgene which encodes a protein which exerts a biological effect on the target cell.
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公开(公告)号：EP2997149A1
公开(公告)日：2016-03-23
申请号：EP14723874.5
申请日：2014-05-12
发明人： HAJITOU, Amin , YATA, Teerapong
CPC分类号： A61K39/385 , A61K35/76 , A61K47/543 , A61K47/59 , A61K47/61 , A61K47/645 , A61K47/6901 , A61K47/6921 , A61K48/00 , A61K2039/5256 , A61K2039/55583 , C07K2319/74 , C12N15/86 , C12N2795/10043 , C12N2795/10045
摘要： The invention provides a targeted bacteriophage-polymer complex comprising a recombinant targeted-bacteriophage and a cationic polymer. The complex has a net positive charge. The invention provides methods of preparing bacteriophages and complexes thereof, and to their uses for the delivery of transgenes in a variety of gene therapy applications.
摘要翻译： 本发明提供了包含重组靶向噬菌体和阳离子聚合物的靶向噬菌体 - 聚合物复合物。 该综合体有净正电荷。 本发明提供了制备噬菌体及其复合物的方法，以及它们在各种基因治疗应用中递送转基因的用途。
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公开(公告)号：EP1587520A1
公开(公告)日：2005-10-26
申请号：EP04701383.4
申请日：2004-01-12
发明人： SHARP, Richard , HUGHES, Gavin , HART, A.,Deptartment of Medical Microbiology and , WALKER, James Taggart
CPC分类号： A61K35/76 , A61K38/51 , C12N7/00 , C12N9/88 , C12N2795/00032 , C12N2795/10032 , C12N2795/10043 , C12Y402/02003 , A61K2300/00
摘要： The present invention provides a composition for treating a bacterial biofilm, comprising a first bacteriophage that is capable of infecting a bacterium within said biofilm, and a first polysaccharide lyase enzyme that is capable of degrading a polysaccharide within said biofilm. The composition preferably further comprises a pharmaceutically-acceptable antimicrobial agent, and may also include a DNase. Also provided are modified bacteriophages, methods of creating modified bacteriophages, use of said compositions and bacteriophage for treating biofilms, and methods for treating biofilms using the bacteriophages and compositions of the invention.
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6.发明公开
公开(公告)号：EP1135535A2
公开(公告)日：2001-09-26
申请号：EP99958449.3
申请日：1999-12-03
申请人： Phagetech Inc.
CPC分类号： C12Q1/18 , A61K38/00 , C07K14/005 , C12N2795/10022 , C12N2795/10043
摘要： A method for identifying suitable targets for antibacterial agents based on identifying targets of bacteriophage-encoded proteins is described. Also described are compositions useful in the identification methods and in inhibiting bacterial growth, and methods for preparing and using such compositions.
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公开(公告)号：EP1005377A2
公开(公告)日：2000-06-07
申请号：EP98943466.7
申请日：1998-08-28
发明人： LAROCCA, David , BAIRD, Andrew , JOHNSON, Wendy
CPC分类号： C40B40/02 , A61K47/6901 , A61K48/00 , C07K14/005 , C07K14/503 , C07K2319/00 , C12N7/00 , C12N15/1037 , C12N15/86 , C12N15/87 , C12N2795/10022 , C12N2795/10043 , C12N2795/10045 , C12N2795/14122 , C12N2810/851
摘要： Filamentous phage particles displaying a ligand on their surface are used to deliver a therapeutic gene to a cell. The ligand is a fusion protein with a phage capsid protein, covalently conjugated to phage particles, or complexed with modified phage particles.
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公开(公告)号：EP1587520B1
公开(公告)日：2009-08-12
申请号：EP04701383.4
申请日：2004-01-12
发明人： SHARP, Richard , HUGHES, Gavin , HART, A., Deptartment of Medical Microbiology and , WALKER, James Taggart
CPC分类号： A61K35/76 , A61K38/51 , C12N7/00 , C12N9/88 , C12N2795/00032 , C12N2795/10032 , C12N2795/10043 , C12Y402/02003 , A61K2300/00
摘要： The present invention provides a composition for treating a bacterial biofilm, comprising a first bacteriophage that is capable of infecting a bacterium within said biofilm, and a first polysaccharide lyase enzyme that is capable of degrading a polysaccharide within said biofilm. The composition preferably further comprises a pharmaceutically-acceptable antimicrobial agent, and may also include a DNase. Also provided are modified bacteriophages, methods of creating modified bacteriophages, use of said compositions and bacteriophage for treating biofilms, and methods for treating biofilms using the bacteriophages and compositions of the invention.
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公开(公告)号：EP0553117A4
公开(公告)日：1994-11-23
申请号：EP91916770
申请日：1991-09-05
申请人： ENZON LAB INC , US AGRICULTURE
发明人： JACOBSON JAMES W , STRAUSBERG ROBERT L , WILSON SUSAN D , POPE SHARON H , STRAUSBERG SUSAN LEE , RUFF MICHAEL D , AUGUSTINE PATRICIA C , DANFORTH HARRY D
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , C12P21/00 , C07H15/12 , C12N1/20 , C12N15/00
CPC分类号： C12N15/70 , A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N15/81 , C12N15/86 , C12N2795/10043 , Y10S530/822
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公开(公告)号：EP0553117A1
公开(公告)日：1993-08-04
申请号：EP91916770.0
申请日：1991-09-05
发明人： JACOBSON, James, W. , STRAUSBERG, Robert, L. , WILSON, Susan, D. , POPE, Sharon, H. , STRAUSBERG, Susan, Lee , RUFF, Michael, D. , AUGUSTINE, Patricia, C. , DANFORTH, Harry, D.
CPC分类号： C12N15/70 , A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N15/81 , C12N15/86 , C12N2795/10043 , Y10S530/822
摘要： Nouvelles protéines antigéniques de recombinaison de la coccidiose aviaire, fragments desdites protéines contenant des déterminants antigéniques, et gènes codant les peptides antigéniques. On décrit aussi des vaccins préparés en utilisant les nouvelles protéines antigéniques de la coccidiose aviaire et des méthodes permettant d'immuniser les poulets contre les coccidioses aviaires.
摘要翻译： 禽类球虫病的新型重组抗原性蛋白质，含有抗原决定簇的所述蛋白质的片段，以及编码抗原肽的基因。 还描述了使用禽类球虫病的新型抗原性蛋白质制备的疫苗和用于免疫鸡抵抗鸟类球虫病的方法。
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