公开(公告)号：EP2968557A1

公开(公告)日：2016-01-20

申请号：EP14775563.1

申请日：2014-03-13

申请人： Health Research, Inc.

发明人： SEGAL, Brahm, H. ,  ABRAMS, Scott ,  ODUNSI, Kunle ,  GRIMM, Melissa ,  KHAN, Nazmul, H. ,  KOLOMEYEVSKAYA, Nonna ,  SINGEL, Kelly

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P37/02

CPC分类号： A61K39/3955 ,  A61K39/0011 ,  A61K39/39 ,  A61K39/39583 ,  A61K2039/505 ,  A61K2039/545 ,  A61K2039/5555 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/57 ,  C07K16/2845 ,  G01N33/5011 ,  G01N2500/10 ,  A61K2300/00

摘要： Provided is a method for enhancing the efficacy of cancer vaccines, such as tumor vaccines. The method involves administering to an individual who is in need of therapy for a tumor an anti-cancer agent and an agent that causes depletion of myeloid cells and/or inhibits recruitment of myeloid cells to the tumor. The effect of the anti-cancer agent on the tumor is greater relative to the effect of the anti-cancer agent in the absence of the anti-myeloid cell agent. Also provided is a method for identifying candidates for the therapy. This approach involves determining if an individual has a tumor characterized by undesirable myeloid cell proliferation and/or tumor infiltration and/or myeloid cell recruitment to the tumor, and if such determination is made, designating the individual as a candidate for the therapy. In one emobidment, the identification of the individual as such a candidate is followed by the therapeutic approach.