公开(公告)号：EP3394100A1

公开(公告)日：2018-10-31

申请号：EP16819574.1

申请日：2016-12-23

申请人： Sorbonne Université ,  Centre National de la Recherche Scientifique ,  INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： SENNLAUB, Florian ,  CALLIPPE, Bertrand ,  GUILLONNEAU, Xavier ,  SAHEL, José-Alain

IPC分类号： C07K16/28

CPC分类号： C07K16/2845 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/76

摘要： The present invention relates to agents inhibiting the interaction between CFH and CD11b/18. The present invention also relates to the use of said agents, in particular for treating inflammatory disorders, such as age-related macular degeneration.

公开(公告)号：EP3042668B1

公开(公告)日：2018-09-19

申请号：EP15195847.7

申请日：2007-06-06

申请人： The Board of Trustees of the Leland Stanford Junior University ,  Department of Veterans Affairs ,  Fabene, Paolo ,  Constantin, Gabriela

发明人： FABENE, Paolo ,  CONSTANTIN, Gabriela ,  BUTCHER, Eugene C.

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P25/08

CPC分类号： A61K39/3955 ,  C07K16/2821 ,  C07K16/2836 ,  C07K16/2842 ,  C07K16/2845 ,  C07K16/2854 ,  C07K16/2896 ,  C07K2317/76

摘要： Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy. The agent is a a selective antagonist, which binds to an adhesion molecule being a selectin or a ligand thereof, such as P-selectin glycoprotein ligand-1.

公开(公告)号：EP2983711A4

公开(公告)日：2016-11-23

申请号：EP14783179

申请日：2014-04-08

申请人： CYTODYN INC

发明人： TRAUGER RICHARD

IPC分类号： C07K16/28 ,  A61K39/395

CPC分类号： C07K16/2845 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76

公开(公告)号：EP3052189A1

公开(公告)日：2016-08-10

申请号：EP14850704.9

申请日：2014-10-02

申请人： Leuvas Therapeutics

发明人： CONSTANTIN, Gabriela

IPC分类号： A61P25/28

CPC分类号： C07K16/2845 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2821 ,  C07K16/2836

摘要： Methods for treating and reducing the progression of neurodegenerative diseases, including, without limitation Alzheimer's disease, are provided. The methods of the invention reduce or deplete neutrophil/myeloid cells in the region of the brain by blocking neutrophil/myeloid cell adhesion and interaction with the vascular endothelium, by blocking infiltration of neutrophil/myeloid cells into the brain, by reducing motility of neutrophil/myeloid cells in the parenchyma, by blocking Aβ-induced activation and adhesion of neutrophil/myeloid cells, and/or by blocking Aβ-induced integrin activation, degranulation and/or ROS release in neutrophil/myeloid cells.

摘要翻译： 提供了治疗和减少神经变性疾病进展的方法，包括但不限于阿尔茨海默氏病。 本发明的方法通过阻止嗜中性粒细胞/骨髓细胞粘附和与血管内皮的相互作用，通过阻止嗜中性粒细胞/骨髓细胞浸润到脑中来减少或消除大脑区域中的嗜中性粒细胞/骨髓细胞，通过减少嗜中性粒细胞/ 通过阻断中性粒细胞/骨髓细胞的活化和粘附和/或通过阻断中性粒细胞/骨髓细胞中的A＆bgr诱导的整联蛋白激活，脱粒和/或ROS释放来实质的骨髓细胞。

公开(公告)号：EP3042668A1

公开(公告)日：2016-07-13

申请号：EP15195847.7

申请日：2007-06-06

申请人： The Board of Trustees of the Leland Stanford Junior University ,  Department of Veterans Affairs ,  Fabene, Paolo ,  Constantin, Gabriela

发明人： FABENE, Paolo ,  CONSTANTIN, Gabriela ,  BUTCHER, Eugene C.

IPC分类号： A61K39/00 ,  A61P25/08

CPC分类号： A61K39/3955 ,  C07K16/2821 ,  C07K16/2836 ,  C07K16/2842 ,  C07K16/2845 ,  C07K16/2854 ,  C07K16/2896 ,  C07K2317/76

摘要： Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy. The agent is a a selective antagonist, which binds to an adhesion molecule being a selectin or a ligand thereof, such as P-selectin glycoprotein ligand-1.

公开(公告)号：EP2844287A4

公开(公告)日：2016-01-27

申请号：EP13784426

申请日：2013-03-15

申请人： UNIV NEW YORK

发明人： TORRES VICTOR J ,  DUMONT ASHLEY L

IPC分类号： A61K39/395 ,  A61P31/04 ,  C07K14/705

CPC分类号： C07K16/2845 ,  A61K38/1741 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/31 ,  C07K14/4354 ,  C07K14/473 ,  C07K14/70553 ,  C07K2317/76 ,  C07K2319/21 ,  G01N33/56938

摘要： The present invention relates to methods of treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection a subject that involves administering a CD11b inhibitor. The present invention further relates to a non-human transgenic animal expressing human CD11b and its use in methods of identifying novel therapeutics for the treatment and prevention of Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection.

公开(公告)号：EP2301570B1

公开(公告)日：2016-01-27

申请号：EP10012296.9

申请日：2003-06-16

申请人： Immunomedics, Inc.

发明人： Goldenberg, David M. ,  Hansen, Hans

IPC分类号： A61K51/10 ,  C07K16/28

CPC分类号： C07K16/2896 ,  A61K51/1018 ,  A61K51/1045 ,  A61K51/109 ,  A61K51/1093 ,  C07K16/2812 ,  C07K16/2815 ,  C07K16/2821 ,  C07K16/2827 ,  C07K16/2845 ,  C07K16/2851 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/2893

公开(公告)号：EP2968557A1

公开(公告)日：2016-01-20

申请号：EP14775563.1

申请日：2014-03-13

申请人： Health Research, Inc.

发明人： SEGAL, Brahm, H. ,  ABRAMS, Scott ,  ODUNSI, Kunle ,  GRIMM, Melissa ,  KHAN, Nazmul, H. ,  KOLOMEYEVSKAYA, Nonna ,  SINGEL, Kelly

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P37/02

CPC分类号： A61K39/3955 ,  A61K39/0011 ,  A61K39/39 ,  A61K39/39583 ,  A61K2039/505 ,  A61K2039/545 ,  A61K2039/5555 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/57 ,  C07K16/2845 ,  G01N33/5011 ,  G01N2500/10 ,  A61K2300/00

摘要： Provided is a method for enhancing the efficacy of cancer vaccines, such as tumor vaccines. The method involves administering to an individual who is in need of therapy for a tumor an anti-cancer agent and an agent that causes depletion of myeloid cells and/or inhibits recruitment of myeloid cells to the tumor. The effect of the anti-cancer agent on the tumor is greater relative to the effect of the anti-cancer agent in the absence of the anti-myeloid cell agent. Also provided is a method for identifying candidates for the therapy. This approach involves determining if an individual has a tumor characterized by undesirable myeloid cell proliferation and/or tumor infiltration and/or myeloid cell recruitment to the tumor, and if such determination is made, designating the individual as a candidate for the therapy. In one emobidment, the identification of the individual as such a candidate is followed by the therapeutic approach.

公开(公告)号：EP1752465B1

公开(公告)日：2011-05-25

申请号：EP06022818.6

申请日：1996-04-05

申请人： Genentech, Inc.

发明人： Rinderknecht, Ernst H. ,  Zapata, Gerardo A.

IPC分类号： C07K16/00 ,  C07K16/46

CPC分类号： C07K16/32 ,  A61K38/00 ,  C07K1/20 ,  C07K16/065 ,  C07K16/2845 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  Y10S435/803

公开(公告)号：EP2168986A3

公开(公告)日：2010-07-28

申请号：EP09179091.5

申请日：2005-02-18

申请人： Genentech, Inc.

发明人： Dennis, Mark S.

IPC分类号： C07K16/46 ,  C12N15/10

CPC分类号： C07K16/464 ,  C07K16/2845 ,  C07K16/2896 ,  C07K16/36 ,  C07K16/4291 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/92

摘要： The present application concerns restoring antigen binding during humanization of antibodies through the selection of repaired hypervariable regions rather than through framework changes.