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公开(公告)号：EP2327763B1
公开(公告)日：2018-03-14
申请号：EP10179257.0
申请日：2006-08-04
申请人： Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH , Max-Delbrück-Centrum für Molekulare Medizin (MDC)
IPC分类号： C12N5/10 , C07K14/725 , C12N15/12 , C12N5/0783 , C12N5/0784 , A61K39/00 , C07K14/705
CPC分类号： C07K14/705 , A61K2039/5154 , A61K2039/5156 , C12N5/0636 , C12N5/0639 , Y02A50/386 , Y02A50/412
摘要： The present invention is directed to a method of generating antigen specific T cells. Furthermore, the invention is directed to antigen specific T cells, isolated transgenic TCR's, pharmaceutical compositions containing same and their use in adoptive cell therapy. This invention in particular pertains to the use of cells co-expressing allogeneic MHC molecules and antigens to induce peptide-specific T cells from non-selected allogeneic T cell repertoires.
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公开(公告)号：EP3369812A1
公开(公告)日：2018-09-05
申请号：EP18161391.0
申请日：2006-08-04
申请人： Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) , Max-Delbrück-Centrum für Molekulare Medizin (MDC)
IPC分类号： C12N5/10 , C07K14/725 , C12N15/12 , C12N5/0783 , C07K14/705 , C12N5/0784 , A61K39/40 , A61K39/00
摘要： The present invention is directed to a method of generating antigen specific T cells. Furthermore, the invention is directed to antigen specific T cells, isolated transgenic TCR's, pharmaceutical compositions containing same and their use in adoptive cell therapy. This invention in particular pertains to the use of cells co-expressing allogeneic MHC molecules and antigens to induce peptide-specific T cells from non-selected allogeneic T cell repertoires.
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公开(公告)号：EP3369812B1
公开(公告)日：2020-10-07
申请号：EP18161391.0
申请日：2006-08-04
申请人： Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) , Max-Delbrück-Centrum für Molekulare Medizin (MDC)
IPC分类号： C12N5/10 , C07K14/725 , C12N15/12 , C12N5/0783 , C07K14/705 , C12N5/0784 , A61K39/40 , A61K39/00
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公开(公告)号：EP2327763A1
公开(公告)日：2011-06-01
申请号：EP10179257.0
申请日：2006-08-04
申请人： Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH , Max-Delbrück-Centrum für Molekulare Medizin (MDC)
IPC分类号： C12N5/10 , C07K14/725 , C12N15/12 , C12N5/0783 , C12N5/0784
CPC分类号： C07K14/705 , A61K2039/5154 , A61K2039/5156 , C12N5/0636 , C12N5/0639 , Y02A50/386 , Y02A50/412
摘要： The present invention is directed to a method of generating antigen specific T cells. Furthermore, the invention is directed to antigen specific T cells, isolated transgenic TCR's, pharmaceutical compositions containing same and their use in adoptive cell therapy. This invention in particular pertains to the use of cells co-expressing allogeneic MHC molecules and antigens to induce peptide-specific T cells from non-selected allogeneic T cell repertoires.
摘要翻译： 本发明涉及产生抗原特异性T细胞的方法。 此外，本发明涉及抗原特异性T细胞，分离的转基因TCR，含有它们的药物组合物及其在过继性细胞治疗中的用途。 本发明特别涉及共表达同种异体MHC分子和抗原的细胞在非选择的同种异体T细胞库中诱导肽特异性T细胞的用途。
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