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1.发明公开MICRORNAS FOR PREDICTION OF TREATMENT EFFICACY AND PROGNOSIS OF CANCER PATIENTS 审中-公开MIKRO-RNA ZUR VORHERSAGE DER BEHANDLUNGSEFFIZIENZ UND PROGNOSE VON KREBSPATITENTEN
公开(公告)号：EP2804959A2
公开(公告)日：2014-11-26
申请号：EP13702886.6
申请日：2013-01-16
申请人： Herlev Hospital
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178
摘要： The present invention lies within the field of personalised medicine. More particular the invention relates to biomarkers useful for predicting treatment efficacy and prognosis in cancer patients. Thus the invention provides micro RNAs (mi RNAs) which are useful for predicting efficacy of anti-angiogenic treatment.
摘要翻译： 本发明在个性化医学领域。 更具体地，本发明涉及可用于预测癌症患者的治疗功效和预后的生物标志物。 因此，本发明提供了可用于预测抗血管生成治疗功效的微小RNA（miRNA）。 特别地，miR-664用于预测乙状结肠或直肠结肠直肠癌贝伐珠单抗的应答。
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2.发明公开MICRORNA FOR DIAGNOSIS OF PANCREATIC CANCER AND/OR PROGNOSIS OF PATIENTS WITH PANCREATIC CANCER BY BLOOD SAMPLES 审中-公开微RNA胰腺肿瘤中血样的诊断和/或病人预后的胰腺肿瘤
公开(公告)号：EP2804958A2
公开(公告)日：2014-11-26
申请号：EP13702885.8
申请日：2013-01-16
申请人： Herlev Hospital , Ruprecht-Karls University of Heidelberg , KRAEFTENS BEKAEMPELSE , Rigshospitalet RH
发明人： JOHANSEN, Julia Sidenius , SCHULTZ, Nicolai Aagaard , WERNER, Jens , JENSEN, Benny Vittrup , ANDERSEN, Klaus K.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to methods for improving the diagnosis and prognosis of patients with pancreatic carcinoma by making use of specific mi RNA biomarkers associated with pancreatic carcinoma that may be identified based on a blood sample from an individual.
摘要翻译： 本发明涉及一种用于通过利用与胰腺癌相关的miRNA特异性生物标志物的改善的患者胰腺癌诊断和预后可识别基于血液样品并，特别是全血，血清或血浆样品的方法，从 个人。
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3.发明公开
公开(公告)号：EP2344886A1
公开(公告)日：2011-07-20
申请号：EP09736115.8
申请日：2009-09-14
发明人： JOHANSEN, Julia Sidenius , BOJESEN, Stig , NORDESTGAARD, Børge Grønne , NIELSEN, Hans Jørgen , CHRISTENSEN, Ib Jarle
IPC分类号： G01N33/53 , G01N33/58 , G01N33/68 , G01N33/574
CPC分类号： G01N33/6887 , G01N33/57419 , G01N33/57488 , G01N2800/52
摘要： The present invention relates to a methods for selecting a treatment for a specific disease or disorder, together with a method of monitoring therapeutic treatment of a specific disease or disorder and a method of determining a prognosis for a subject before, during and after administering a treatment by determining the level of YKL-40 in a sample obtained from the subject and comparing said level with one or more reference levels of YKL-40. The reference level is typically a level obtained from healthy individuals or a level previously obtained from the same subject. The present invention further relates to a kit and a device that may be used in the methods of the present invention.
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4.发明公开
公开(公告)号：EP2710148A2
公开(公告)日：2014-03-26
申请号：EP12726008.1
申请日：2012-05-16
申请人： Herlev Hospital
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to prognostic micro RNA (miRNA) biomarkers based on a specific miRNA expression pattern, which can prove as a valuable prognostic tool to predict the survival of patients being diagnosed with pancreas cancer.
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5.发明公开
公开(公告)号：EP2655660A2
公开(公告)日：2013-10-30
申请号：EP11808822.8
申请日：2011-12-21
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention relates to methods for improving the diagnosis of pancreatic and ampullary adenocarcinomas by making use of specific mi RNA biomarkers and/or mi RNA classifiers.
摘要翻译： 本发明涉及通过利用特定的mi RNA生物标志物和/或mi RNA分类器来改善胰腺和壶腹腺癌的诊断方法。
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