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1.发明授权Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use. 有权（1S，9S）的酯-9 - [[（1S）-1-羧基-3-苯基丙基]氨基]八氢-10-氧代-6H-哒嗪并[1,2-α] [1,2]二氮杂-1 羧酸和其治疗Verwendung-
公开(公告)号：EP2537534B1
公开(公告)日：2014-12-17
申请号：EP11171006.7
申请日：2011-06-22
申请人： Hexal AG
CPC分类号： A61K9/703 , A61K9/7053 , A61K9/7061 , A61K47/54 , A61K47/545 , C07D487/04 , C07K5/06017
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2.发明公开Prodrugs of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their use in transdermal therapeutic systems 有权（1S，9S）-9 - [[（1S）-1-羧基-3-苯基丙基]氨基]八氢-10-氧代-6H-哒嗪并[1,2-a] [1,2]二氮杂-1 -carboxylsäureund ihre therapeutische Verwendung-
公开(公告)号：EP2537534A1
公开(公告)日：2012-12-26
申请号：EP11171006.7
申请日：2011-06-22
申请人： Hexal AG
CPC分类号： A61K9/703 , A61K9/7053 , A61K9/7061 , A61K47/54 , A61K47/545 , C07D487/04 , C07K5/06017
摘要： The present invention relates to diester prodrugs of cilazaprilate which undergo enzymatic cleavage to release the active metabolite cilazaprilate that is used for the treatment of hypertension and congestive heart failure. Furthermore the diester prodrugs of cilazaprilate possess all the properties necessary to be topically administered, preferably via transdermal therapeutic systems.
摘要翻译： 本发明涉及经过酶裂解释放用于治疗高血压和充血性心力衰竭的活性代谢物西拉普利酯的西拉普利的二酯前药。 此外，西拉必利酯的二酯前药具有局部施用所需的所有特性，优选经由透皮治疗系统。
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