公开(公告)号：EP3925606A1

公开(公告)日：2021-12-22

申请号：EP20755904.8

申请日：2020-01-23

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： KUROKAWA Takao ,  ARAKI Hiroyuki ,  KOMATANI Kimiko

IPC分类号： A61K31/381 ,  A61P25/14 ,  A61P25/16 ,  A61K9/70 ,  A61K47/06 ,  A61K47/10 ,  A61K47/22 ,  A61K47/32

摘要： The present invention provides a rotigotine stabilization method for stabilizing rotigotine and/or a pharmaceutically acceptable salt thereof in a rotigotine-containing patch comprising a backing layer and an adhesive agent layer, the adhesive agent layer containing the rotigotine and/or the pharmaceutically acceptable salt thereof and a styrene-based thermoplastic elastomer, the method comprising further incorporating cross-linked polyvinylpyrrolidone in the adhesive agent layer in a content of 3 to 25% by mass in the adhesive agent layer.

公开(公告)号：EP3984598A1

公开(公告)日：2022-04-20

申请号：EP20822737.1

申请日：2020-06-05

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： ARAKI Hiroyuki ,  TAKAGI Yuka ,  FUJIWARA Yoko ,  KOBAYASHI Hiroaki ,  KUROKAWA Takao

IPC分类号： A61P25/00 ,  A61P25/16 ,  A61K9/70 ,  A61K47/06 ,  A61K47/10 ,  A61K47/32 ,  A61K31/381

摘要： The present invention provides a rotigotine-containing patch comprising:
a backing layer; and
an adhesive agent layer, wherein
the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof, and
the adhesive agent layer further contains an alicyclic saturated hydrocarbon resin and at least one aliphatic alcohol selected from the group consisting of lauryl alcohol, octyldodecanol, oleyl alcohol, and myristyl alcohol.

公开(公告)号：EP3919051A1

公开(公告)日：2021-12-08

申请号：EP20749539.1

申请日：2020-01-30

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： KUROKAWA Takao ,  KUMA Hidekazu ,  YUKUHIRO Masaki

IPC分类号： A61K31/13 ,  A61K31/27 ,  A61K31/381 ,  A61K31/403 ,  A61K31/407 ,  A61K31/4422 ,  A61K31/573 ,  A61K45/00 ,  A61P9/12 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P29/00 ,  A61K9/70 ,  A61K47/32 ,  A61K47/34

摘要： The present invention provides a patch comprising an adhesive layer on a backing, wherein the adhesive layer contains a adhesive base, a skin irritant drug or a pharmaceutically acceptable salt thereof, and diflucortolone valerate, and the content of the diflucortolone valerate is 0.0009 to 0.08% by mass based on the total mass of the adhesive layer.

公开(公告)号：EP3730129A1

公开(公告)日：2020-10-28

申请号：EP18893071.3

申请日：2018-12-14

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： ARAKI Hiroyuki ,  TAKAGI Yuka ,  FUJIWARA Yoko ,  KOBAYASHI Hiroaki ,  KUROKAWA Takao

IPC分类号： A61K9/70 ,  A61K31/381 ,  A61K47/10 ,  A61K47/32 ,  A61P25/16 ,  C07D333/20

摘要： The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof,
the adhesive agent layer further contains a styrene-based thermoplastic elastomer, a petroleum-based resin and/or a terpene-based resin, an aliphatic alcohol, and a cross-linked polyvinylpyrrolidone, and
in the adhesive agent layer, a mass ratio of a content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form and a content of the cross-linked polyvinylpyrrolidone (content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form : content of the cross-linked polyvinylpyrrolidone) is 10 : 3 to 1 : 3.